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Chitosan loading copper complex type nano-composite photo-thermal agent and preparation method thereof

A copper complex and nano-composite technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of high drug loading process and cost, and achieve the effect of reducing damage

Inactive Publication Date: 2015-06-10
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, relatively expensive anti-tumor drugs such as doxorubicin are commonly used in chemotherapy at present, and the release of anti-tumor drugs driven by heat or laser response requires precise structural design and modification of photothermal reagents, drug-loading process and The cost is very high

Method used

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  • Chitosan loading copper complex type nano-composite photo-thermal agent and preparation method thereof
  • Chitosan loading copper complex type nano-composite photo-thermal agent and preparation method thereof
  • Chitosan loading copper complex type nano-composite photo-thermal agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Dissolve 40mmol of copper chloride in 5mL of water, then add 13.3mmol of sodium citrate, and stir for 30s to obtain a single carboxyl-complexed copper complex solution. At room temperature of 20°C, after 15 minutes, 808nm, 3.5W / cm 2 After laser irradiation, the solution temperature can rise to 52.7 °C. It shows that the single carboxyl copper complex has good light-to-heat conversion performance.

Embodiment 2

[0028]Dissolve 40mmol of copper chloride in 5mL of water, then add 26.7mmol of sodium citrate, and stir for 30s to obtain a dicarboxylate-complexed copper complex solution. At room temperature of 20°C, after 5 minutes, 808nm, 3.5W / cm 2 After laser irradiation, the solution temperature can rise to 57.5 °C. It shows that the copper complex of dicarboxylate has good light-to-heat conversion performance.

Embodiment 3

[0030] Dissolve 40 mmol of copper chloride in 5 mL of water, then add 40 mmol of sodium citrate, and stir for 30 s to obtain a copper complex solution complexed with tricarboxylic groups. At room temperature of 20°C, after 15 minutes, 808nm, 3.5W / cm 2 After laser irradiation, the solution temperature can rise to 59.2 °C. It shows that the tricarboxylic copper complex has good light-to-heat conversion performance.

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Abstract

The invention provides a chitosan loading copper complex type nano-composite photo-thermal agent and a preparation method thereof, and belongs to the technical field of functional materials. The method comprises the steps of ultrasonically dissolving chitosan, copper salt and a polycarboxylic radial compound; dropwise adding a sodium hydroxide solution to the solution while agitating; regulating the pH of the mixed solution to be 3.2 to 3.6, wherein the mole ratio of used chitosan to copper salt to the polycarboxylic radial compound is 1: (1400-5800): (4500-7500); centrifuging the solution to separate out a copper complex loaded chitosan nanoparticle composite which is the chitosan loading copper complex type nano-composite photo-thermal agent with the photo-thermal converting performance. The water-soluble copper complex containing chitosan nanoparticle composite of different size can be applied to photo-thermal treatment; sufficient heat energy can be provided for photo-thermal tumor treatment, and the requirement of ablating tumor without damaging healthy tissue and organs can be met.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a chitosan-loaded copper complex nanocomposite photothermal reagent with photothermal conversion performance and a preparation method thereof. Background technique [0002] In order to achieve non-destructive treatment of tumor patients, researchers have developed photothermal therapy by using the properties of certain nanoparticles to absorb near-infrared light and generate heat. In order to reduce the damage to normal tissues and organs, photothermal therapy usually uses 650-980nm near-infrared laser as the light source, and then utilizes the characteristics of poor heat tolerance of tumor cells to achieve the purpose of photothermal therapy for tumors. Compared with traditional radiotherapy and chemotherapy, photothermal therapy has shown obvious advantages. However, photothermal therapy alone still faces the problem of recurrence after tumor treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/36A61K31/194A61K31/19A61K9/14A61P35/00
Inventor 张皓林敏刘树威杨柏孙宏晨
Owner JILIN UNIV
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