A liquid chromatography sampling channel cleaning device
A liquid chromatography and cleaning device technology, which is applied in the field of liquid chromatography instrument analysis, can solve problems such as pollution, affecting the repeatability of sample injection, clogging, etc., and achieve strong universality, improve repeatability of sample injection, and improve analysis efficiency. Effect
Active Publication Date: 2016-08-24
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology
[0005] The common features of the above two methods are: 1. The cleaning solution enters the sampling channel in the same direction as the sample injection direction, so the particles on the sampling filter continue to accumulate, which easily leads to clogging and sample contamination; 2. The cleaning solution resides in the sampling channel. Therefore, when re-sampling, a small part of the cleaning solution will be mixed into the sample solution, dilute the sample solution, and affect the repeatability of the injection
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Embodiment 1
[0028] A liquid chromatography sampling channel cleaning device, such as figure 1 As shown, it is mainly composed of a micro-flow infusion pump 100, a compressed air source 200, a capillary flow restrictor 201, a liquid-gas switching valve 110, a sampling-cleaning switching valve 120, a waste liquid collection cup 420, a waste liquid bottle 430, and a sampling The valve 410, the sampling port 400 and the program controller are composed; the liquid-gas switching valve 110 and the sampling-cleaning switching valve 120 are three-way solenoid valves, and the sampling valve 410 is a two-position six-way solenoid valve. The working state of the three valve bodies is controlled by the program controller.
[0029] The common end ① of the sampling-cleaning switching valve 120 is connected to the ⑥ position of the sampling valve 410 through a pipeline, and the normally open end ② of the sampling-cleaning switching valve 120 is connected to the waste liquid bottle 430 with a pipeline, wh...
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The invention provides a liquid chromatographic sampling passage cleaning device. The liquid chromatographic sampling passage cleaning device mainly comprises a microfluidic pump, a compressed air source, a capillary flow limiter, a liquid-gas switching valve, a sampling-cleaning switching valve, a waste liquid collecting cup, a waste liquid bottle, a sampling valve, a sampling port and a program controller. After sampling, a cleaning solution is used for reversely rinsing a liquid chromatographic sampling passage to reversely rinse particles left on a filter in the sampling process and discharge the particles out of a sampling pipeline first and then microflow gas is used for reversely purging the sampling passage to expel liquid left inside the pipeline so as to avoid sample dilution during sampling once again. The liquid chromatographic sampling passage cleaning device is suitable for various analytical-grade liquid chromatographs, comprising positive chromatography, reverse chromatography, ion chromatography and the like, as well as suitable for cleaning a sampling loop for flow injection analysis, so that cross pollution of samples is avoided, the sampling repeating precision is improved, and the service life of the sampling filter can be greatly prolonged.
Description
technical field [0001] The invention relates to the field of analysis of liquid chromatography instruments, and belongs to an auxiliary device for analysis instruments. Specifically, it is a cleaning device for a sampling channel of a liquid chromatography instrument, which can avoid cross-contamination between samples during the analysis process of a liquid chromatography instrument. And eliminate the dilution of the new sample by the residual liquid in the injection channel, significantly improving the reliability and repeatability of the analysis. Background technique [0002] Liquid chromatography is a widely used separation and detection instrument. It is often used in the analysis and detection of large quantities of samples in the laboratory, and has played an important role in many fields such as drug analysis, inspection and quarantine, and environmental monitoring. Due to the wide variety of samples analyzed and the large differences in properties, in order to avoi...
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IPC IPC(8): B08B9/032
CPCB08B9/0321B08B9/0325F26B21/00
Inventor 关亚风田晓静孟虎
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI