P substance peptide probe capable of specific recognition of neurokinin-1 receptor protein, and preparation and application thereof

A technology of receptor protein and neurokinin, applied in the preparation method of peptide, preparation for in vivo test, tachykinin, etc.
CN104744568AInactive Publication Date: 2015-07-01EAST CHINA UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EAST CHINA UNIV OF SCI & TECH
Publication Date
2015-07-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a P substance peptide probe capable of specific recognition of a neurokinin-1 receptor protein. the P substance peptide probe is a polypeptide dimer or a polypeptide polymer, the monomer is formed by a P substance amino acid sequence MLGFFQQPKPR, a bifunctional chelating group, a fluorescence group and a terpyridyl group connected through lysine. The novel peptide probe is used for the preparation of a polypeptide dimer and polypeptide polymer with function of diagnosing multi tumors. The polypeptide dimer and polypeptide polymer marks metal Gd<3+> to a polypeptide molecule by the bifunctional chelating group; the marked P substance peptide probe and the NK-1 receptor protein specifically bind and concentrate to the tumor site in vivo; and magnetic imaging and optical imaging technology are utilized for detection of the neurokinin-1 receptor protein to improve the sensitivity of the detection.
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Description

technical field

[0001] The present invention relates to the field of drugs for tumor diagnosis, in particular to a substance P polypeptide probe specifically recognizing neurokinin-1 receptor protein and its preparation and application. The substance P polypeptide probe is a novel polypeptide dimer and Polypeptide polymers that detect tumors by specifically binding to the neurokinin-1 (NK-1) receptor protein in tumors. Background technique

[0002] Lung cancer is one of the most common malignant tumors. Lung cancer ranks first among the causes of death from malignant tumors in urban population in my country. There is no obvious improvement in 10, and the total cure rate is about 10%. At present, there is a lack of specific indicators and methods for early diagnosis, and some tests that affect diagnostic staging are difficult to popularize and implement. Lung cancer patients have no specific symptoms in the early stage, so most of them are in the middle and late stages when t...

Claims

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