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A kind of preparation method of pdlla-peg-pdlla triblock copolymer anti-adhesion gel

A preparation method and technology of copolymers, applied in medical science, surgery, etc., can solve problems such as difficult to meet clinical requirements

Active Publication Date: 2017-10-31
SHANGHAI JINGFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anti-adhesion film, polylactic acid anti-adhesion gel, anti-adhesion liquid and other materials currently reported have their own advantages, but they also have their shortcomings, and it is difficult to meet the ideal clinical requirements.

Method used

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  • A kind of preparation method of pdlla-peg-pdlla triblock copolymer anti-adhesion gel
  • A kind of preparation method of pdlla-peg-pdlla triblock copolymer anti-adhesion gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 26.6 g of anhydrous disodium hydrogen phosphate and 1.35 g of sodium dihydrogen phosphate monohydrate, and dissolve them in 1000 ml of water for injection to prepare a phosphate buffer solution for use.

[0037] Weigh 150 g of the above-prepared PDLLA-PEG-PDLLA triblock copolymer, dissolve it in the above-mentioned phosphate buffer solution, and prepare the PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel with a concentration of 15 wt%, and filter aseptically , aseptically filled to prepare PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel, marked as sample B.

Embodiment 2

[0039] Weigh 22.3 g of anhydrous disodium hydrogen phosphate and 1.21 g of sodium dihydrogen phosphate monohydrate, and dissolve them in 1000 ml of water for injection to prepare a phosphate buffer solution for use.

[0040] Weigh 160 g of the PDLLA-PEG-PDLLA triblock copolymer prepared above, dissolve it in the above-mentioned phosphate buffer solution, and prepare the PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel with a concentration of 16 wt%, and filter it aseptically , aseptically filled to prepare PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel, marked as sample C.

Embodiment 3

[0042] Weigh 13.5 g of anhydrous disodium hydrogen phosphate and 0.76 g of sodium dihydrogen phosphate monohydrate, and dissolve them in 1000 ml of water for injection to prepare a phosphate buffer solution for use.

[0043] Weigh 120 g of the PDLLA-PEG-PDLLA triblock copolymer prepared above, dissolve it in the above-mentioned phosphate buffer solution, and prepare the PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel with a concentration of 12 wt%, and filter it aseptically , aseptically filled to prepare PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel, marked as sample D.

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Abstract

The present invention relates to a kind of preparation method of PDLLA-PEG-PDLLA three-block copolymer anti-adhesion gel, the technical problem to be solved by the present invention is the normal temperature storage condition and Stability issues. First prepare a phosphate buffer solution, then add PDLLA-PEG-PDLLA triblock copolymer to the solution, stir and dissolve, and obtain PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel. The present invention provides a method for enhancing the stability of PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel.

Description

Technical field: [0001] The invention relates to a preparation method of PDLLA-PEG-PDLLA triblock copolymer anti-adhesion gel. Background technique: [0002] 1. Postoperative adhesion is a common clinical problem after abdominal, gynecological, and cardiac surgery, and is the main cause of postoperative complications such as intestinal obstruction, infertility, and pain. In recent years, it has become a new trend in the world to prevent postoperative adhesions by implanting isolation materials in the parts prone to postoperative adhesions. However, the anti-adhesion film, polylactic acid anti-adhesion gel, anti-adhesion liquid and other materials currently reported have their own advantages, but they also have their shortcomings, and it is difficult to meet the ideal clinical requirements. [0003] 2. PDLLA-PEG-PDLLA triblock copolymer was disclosed in the Chinese patent application document of "Use of PDLLA-PEG-PDLLA triblock copolymer in the preparation of medical anti-ad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/14A61L31/02C08G63/664C08G65/48
Inventor 叶湘武张云刘华付爱玲
Owner SHANGHAI JINGFENG PHARMA
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