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A combined standard quantity for judging the amount of markers for risk detection of early gastric cancer and its application in screening early gastric cancer

A technology for early gastric cancer and risk detection, applied in the medical field, can solve the problems of unsatisfactory screening program specificity, low sensitivity, and low specificity of high G-17 hyperemia screening program alone.

Active Publication Date: 2017-04-19
BIOHIT BIOTECH HEFEI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 1. The specificity of the screening scheme for PG Ⅰ ≤ 70 ng / ml and PG Ⅰ / PG Ⅱ ≤ 3 is not very satisfactory;
[0009] 2. The specificity of the screening scheme for hyperG-17emia alone is not high;
[0011] 4. The specificity of PG Ⅰ, PG Ⅰ / PG Ⅱ combined with low G-17emia is as high as 98.9%, but the sensitivity is very low at 12.3%

Method used

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  • A combined standard quantity for judging the amount of markers for risk detection of early gastric cancer and its application in screening early gastric cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example 1

[0026] Perform gastrin-17 (G-17) and pepsinogen I / II (PGI / PG Ⅱ) in the venous blood of the candidates for comparative analysis.

Embodiment example 2

[0028] Gastrin 17 (G-17) pepsinogen I / II (PGI / PG Ⅱ) amount detection method:

[0029] The method of ELISA was adopted to detect, and the detection kit was purchased from Biohit, Finland.

Embodiment example 3

[0031] 1174 cases of gastroscopy in Dingyuan, Anhui (1 case of gastric cancer):

[0032] G-17≥15pmol / L and PGⅠ≤70ng / ml and PGⅠ / PGII≤7; or PG-17≤1pmol / L and PGⅠ≤70ng / ml and PGⅠ / PGⅡ≤7 detected early There were 10 high-risk patients with gastric cancer, and the results of gastroscopy included 1 case of early gastric cancer. The remaining 9 patients all had chronic atrophic gastritis (5 cases in the active stage), including 3 cases with intestinal metaplasia, 2 cases with glandular low-grade intraepithelial neoplasia, and 2 cases with gastric polyps.

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Abstract

The invention provides a combined standard quantity for determining the quantity of a marker used in early gastric cancer risk detection and an application thereof in early gastric cancer screening, and particularly relates to evaluation of the risk index of early gastric cancer through combined detection of the quantity of gastrin 17 (G-17) and pepsinogen I / II (PGI / PGII) in venous blood of a person to be tested, The application of the standard quantity in the early gastric cancer screening is quite high in both specificity and sensitivity.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a combined standard amount for judging the amount of markers for risk detection of early gastric cancer and its application in screening early gastric cancer. Background technique [0002] Gastric cancer is a malignant tumor with high incidence worldwide, especially in my country. Ten years ago, the incidence of gastric cancer ranked first in my country. There are obvious regional differences in the incidence of gastric cancer in my country. The incidence of gastric cancer in the northwest and eastern coastal areas of China is significantly higher than that in the south. The age of onset is more than 50 years old, and the ratio of male to female incidence is 2:1, showing a higher incidence tendency in males. The incidence of gastric cancer in the world is mainly concentrated in three countries - China, South Korea and Japan. The combined incidence of gastric cancer in these three countr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57446G01N2800/7028
Inventor 赵俊王明丽刘峰
Owner BIOHIT BIOTECH HEFEI
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