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Organic-inorganic double-shell microcapsule for temperature-controlled release of hydrophobic micromolecules and preparation method thereof

A hydrophobic and microcapsule technology, which is applied in the field of responsive microcapsules and its preparation, to achieve obvious temperature-controlled release ability and high sustained-release efficiency

Active Publication Date: 2015-08-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few public reports on the preparation of microcapsules with chitosan and silicon dioxide as double-wall materials.
[0005] In addition, due to the increase of external temperature during the use of conventional microcapsules, the core material will release rapidly. In order to solve this problem, temperature-controlled release microcapsules have gradually been proposed.

Method used

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  • Organic-inorganic double-shell microcapsule for temperature-controlled release of hydrophobic micromolecules and preparation method thereof
  • Organic-inorganic double-shell microcapsule for temperature-controlled release of hydrophobic micromolecules and preparation method thereof

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preparation example Construction

[0031] The preparation method of the organic-inorganic double-shell microcapsules used for temperature-controlled release of hydrophobic small molecules according to the present invention comprises the following steps:

[0032] Step 1: Add 30-60 mg of amphiphilic tri-block copolymer, 20-40 μL of silica precursor, 3-9 μL of silane coupling agent and 5-15 mg of hydrophobic small molecule substances into 600-800 μL of organic solvent at the same time, After stirring and dissolving at room temperature for 5-10 h, a mixed solution was obtained.

[0033] Step 2: Weigh 90-150 mg of chitosan powder, add it to 15-30 mL of weak acid solution with a mass fraction of 1-3%, stir and dissolve at 30-50°C for 10-40 hours, then cool to room temperature, that is Obtain chitosan solution.

[0034] Step 3: At room temperature, gradually add 400-600 μL of the mixed solution obtained in Step 1 to 10-20 mL of chitosan solution, and the time for adding is 40-60 minutes. During the process of adding,...

Embodiment 1

[0047] Step 1: Add 30 mg of amphiphilic triblock copolymer, 40 μL of silica precursor, 3 μL of silane coupling agent and 15 mg of hydrophobic small molecular substance into 600 μL of organic solvent at the same time, stir and dissolve at room temperature for 10 hours to obtain a mixed solution .

[0048] Step 2: Weigh 90 mg of chitosan powder, add it to 30 mL of weak acid solution with a mass fraction of 1%, stir and dissolve at 50° C. for 10 h, and cool to room temperature to obtain a chitosan solution.

[0049] Step 3: At room temperature, gradually drop 600 μL of the mixed solution obtained in Step 1 into 10 mL of chitosan solution for 60 minutes. During the dropping process, the chitosan solution is always in a stirring state.

[0050] After the dropwise addition was completed, ultrasonic treatment was performed for 5 minutes and continuous stirring was continued for 60 hours to obtain organic-inorganic double-shell microcapsules for temperature-controlled release of hydro...

Embodiment 2

[0062] Step 1: Add 40 mg of amphiphilic triblock copolymer, 35 μL of silica precursor, 5 μL of silane coupling agent and 13 mg of hydrophobic small molecular substance into 660 μL of organic solvent at the same time, stir and dissolve at room temperature for 9 hours, and obtain a mixed solution .

[0063] Step 2: Weigh 110 mg of chitosan powder, add it to 25 mL of weak acid solution with a mass fraction of 1.5%, stir and dissolve at 42° C. for 20 h, and cool to room temperature to obtain a chitosan solution.

[0064] Step 3: At room temperature, 520 μL of the mixed solution obtained in Step 1 was gradually added dropwise to 13 mL of chitosan solution for 52 minutes. During the dropping process, the chitosan solution was always in a stirring state.

[0065] After the dropwise addition, ultrasonic treatment was performed for 8 minutes and continuous stirring was continued for 52 hours to obtain organic-inorganic double-shell microcapsules for temperature-controlled release of hydr...

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Abstract

The invention relates to an organic-inorganic double-shell microcapsule for temperature-controlled release of hydrophobic micromolecules and a preparation method thereof. At present, researches on preparation of microcapsules from chitosan and silicon dioxide used as double-wall materials are rarely reported in public. The preparation method comprises the following steps: simultaneously adding an amphiphilic triblock copolymer, a silicon dioxide precursor, a silane coupling agent and a hydrophobic micromolecule substance into an organic solvent, and dissolving by stirring at room temperature so as to obtain a mixed liquor; adding 90-150 mg of chitosan powder into a weak acidic solution to obtain a chitosan dissolved solution; gradually dropwise adding the mixed liquor into the chitosan dissolved solution at room temperature and carrying out ultrasonic treatment so as to obtain the organic-inorganic double-shell microcapsule for temperature-controlled release of hydrophobic micromolecules. By an interfacial polymerization method, the double-wall microcapsule with chitosan used as an outer shell and silicon dioxide used as an inner shell is obtained. Release rate of a core material is gradually reducing with the rising of temperature. The microcapsule has an obvious temperature-controlled release effect on hydrophobic micromolecules, and release efficiency is high.

Description

technical field [0001] The invention relates to a responsive microcapsule and a preparation method thereof, in particular to an organic-inorganic double-shell microcapsule for temperature-controlled release of hydrophobic small molecules and a preparation method thereof. Background technique [0002] Microcapsule is a kind of micro container with polymer or composite material as wall material. It can use the wall material to wrap solid particles, gas or liquid, change the state of the substance, and reduce the volatility and release rate of the substance to a certain extent, so it is widely used in various fields such as food, medical and textile. [0003] Chitosan is the most abundant aminopolysaccharide in nature. It has unique adhesion, good biodegradability and good antibacterial properties. These special properties make it a widely used microcapsule wall material. In recent years, chitosan-based microcapsules have successfully coated drugs, flavors and dyes, and are ...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/36A61K47/04
Inventor 马建中范倩倩徐群娜
Owner SHAANXI UNIV OF SCI & TECH
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