Pain-free synergistic amoxicillin powder injection for livestock and preparation method thereof
A technology of amoxicillin powder and amoxicillin, which is applied in the direction of powder transportation, active ingredients of heterocyclic compounds, active ingredients of ether/acetals, etc., can solve the problem of poor antipyretic and antipyretic effects, increased work frequency and labor of veterinarians Intensity, head hitting the barn, jumping and trembling, screaming and other problems, to achieve the effect of saving medication costs and labor costs, strengthening antibacterial and cough and asthma effects, and the process is simple and reasonable
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Embodiment 1
[0020] Preparation of veterinary painless synergistic amoxicillin powder injection: first, weigh various ingredients according to parts by weight, active ingredient amoxicillin: sodium carbonate: procaine hydrochloride: probenecid sodium: indomethacin : α-asarone (pre-powder finely passed through a 200-mesh sieve) is 50:30:2.5:6:3:1.0;
[0021] Then, 5 parts of amoxicillin, 5 parts of sodium carbonate, 1.0 part of α-asarone, 2.5 parts of procaine hydrochloride, 6 parts of probenecid sodium and 3 parts of indomethacin were put into SYH- In the 100 three-dimensional motion mixer, pre-mixed for 10 minutes, then dropped into 45 parts of active ingredient amoxicillin (sterile powder for injection, in terms of active ingredient C16H19N3O5S, mass fraction is more than 85%) and 25 parts of sodium carbonate (assistant Solvent, sterile powder for injection, the mass fraction is more than 99%), mixed for 15 minutes to obtain veterinary painless synergistic amoxicillin powder injection; t...
Embodiment 2
[0025] The preparation of veterinary painless synergistic amoxicillin powder injection: first, weigh various ingredients according to the weight parts, the active ingredient amoxicillin sodium: sodium bicarbonate: procaine hydrochloride: probenecid sodium: fluoride Nisin meglumine: α-asarone (pre-powder finely passed through a 300-mesh sieve) is 50:15:2:7:2:0.7;
[0026] Then, 5 parts of amoxicillin sodium, 5 parts of sodium bicarbonate and 0.7 parts of α-asarone, 2 parts of procaine hydrochloride, 7 parts of probenecid sodium, 2 parts of flunixin meglumine Put it into the SYH-100 three-dimensional motion mixer, pre-mix for 10 minutes, and then add 45 parts of amoxicillin sodium (sterile powder for injection, based on the active ingredient C16H19N3O5S, the mass fraction is more than 88%) and 10 parts Sodium bicarbonate (cosolvent, sterile powder for injection, the mass fraction is more than 99%), mixed for 15 minutes to obtain veterinary painless synergistic amoxicillin powder...
Embodiment 3
[0030] Under the conditions of high temperature of 40°C and humidity of 75%±5%, the powder injections prepared in Examples 1 and 2 were subjected to 6-month accelerated test investigation, and the results are shown in Table 1.
[0031] Table 1 Accelerated test of veterinary painless synergistic amoxicillin powder injection
[0032]
[0033] Note: For the data of the test items in Table 1, refer to "National Standards Collection of Veterinary Drugs" - National Standards for Raising Local Standards of Veterinary Drugs (Edited by the Veterinary Drug Evaluation Center of the Ministry of Agriculture, published by China Agricultural Press), Volume 1 P195.
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