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Painless synergistic amoxicillin powder injection for animals and preparation method thereof

A technology of amoxicillin powder and amoxicillin, which is applied in the field of veterinary painless and synergistic amoxicillin powder injection and preparation thereof, can solve the problems of inflammatory pain, anti-inflammatory and analgesic, antipyretic and antipyretic effects that are not ideal, cannot be durable, The economic loss of farmers can be improved, and the effect of strengthening anti-inflammatory, analgesic and antipyretic effects, prolonging half-life and action time, and inhibiting adverse stress reactions can be achieved.

Inactive Publication Date: 2016-11-23
上海宥佳医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In fact, the penicillin powder injections such as amoxicillin currently used in veterinary medicine are generally single powder injections made of penicillin such as amoxicillin or amoxicillin sodium or penicillin sodium (potassium) salt, and are commonly injected into pigs and other livestock. There is stinging stress, pain during injection and diffusion of the drug solution after injection, these pains will cause some adverse stress reactions, some of which are very strong
Many farms have reported that when and after injection with this single penicillin powder such as amoxicillin, livestock, especially young animals, are found to have strong stinging stress, irritability, head hitting the barn, jumping and trembling, screaming One or more stress symptoms such as strange screams, decreased feed intake, lying on the ground, reduced lactation of female animals, abortion of pregnant animals, premature birth, etc., have brought considerable economic losses to farmers; in addition, due to the amoxicillin The half-life is short. After this kind of single powder injection is used, the action time is not long and cannot last long. The medicine is taken 2 to 3 times a day, which increases the work frequency and labor intensity of veterinarians. The antipyretic and antipyretic effect is not ideal, and there are still quite a few livestock that eat less food or are in a fasting state for a period of time after taking the drug

Method used

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  • Painless synergistic amoxicillin powder injection for animals and preparation method thereof
  • Painless synergistic amoxicillin powder injection for animals and preparation method thereof
  • Painless synergistic amoxicillin powder injection for animals and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] The preparation of veterinary painless synergistic amoxicillin powder injection: first, weigh various ingredients according to parts by weight, amoxicillin: sodium carbonate: procaine hydrochloride: probenecid sodium: indomethacin: wild jujube Kernel extract: the weight ratio of polygala extract is 52:30:2.5:8:2:0.5:0.8; then, first 2.5 parts of procaine hydrochloride, 8 parts of probenecid sodium, 2 parts of indomethacin , 0.5 parts of Suanzaoren extract and 0.8 part of Polygala extract are put into the SYH-100 three-dimensional motion mixer, pre-mixed for 10 minutes, then put into 52 parts of amoxicillin and 30 parts of sodium carbonate, and mix for 15 minutes, that is Obtain the painless synergistic amoxicillin powder injection for veterinary use; The powder injection material that mixes is transferred on the KGL-120 type antibiotic glass bottle screw-screw dispensing machine, carries out sub-package, and the filling amount of every bottle is 0.5g or 1.0g (both with ...

Embodiment 2

[0025] The preparation of painless synergistic amoxicillin powder injection for veterinary use: first, weigh various ingredients according to parts by weight, amoxicillin: sodium carbonate: lidocaine hydrochloride: probenecid sodium: flunixin meglumine: Jujube seed extract: the weight ratio of polygala extract is 50:20:2:6.5:1.5:1:0.5; then, 2 parts of lidocaine hydrochloride, 6.5 parts of probenecid sodium, 1.5 parts of flunixin Methylamine, 1 part of Suanzaoren extract, 0.5 part of Polygala extract, put into SYH-100 three-dimensional motion mixer, pre-mix for 10 minutes, then add 50 parts of amoxicillin and 20 parts of sodium carbonate, and mix for 15 minutes , to obtain veterinary painless synergistic amoxicillin powder injection; the mixed powder injection material is transferred to the KGL-120 type antibiotic glass bottle screw filling machine for subpackaging, and the amount of each bottle is 0.5g or 1.0g ( All with effective amoxicillin component C 16 h 19 N 3 o 5 S...

Embodiment 3

[0029] The preparation of veterinary painless synergistic amoxicillin powder injection: first, weigh various ingredients according to parts by weight, amoxicillin: sodium carbonate: methocaine hydrochloride: probenecid sodium: piroxicam: jujube seed extract The weight ratio of compound: polygala extract is 48: 10: 1: 5: 1: 0.6: 0.7; Put the kernel extract and 0.7 parts of polygala extract into the SYH-100 three-dimensional motion mixer, pre-mix for nearly 10 minutes, then add 48 parts of amoxicillin and 10 parts of sodium carbonate, and mix for 15 minutes to obtain veterinary Painless synergistic amoxicillin powder injection; then, transfer the mixed powder injection material to the KGL-120 type antibiotic glass bottle screw filling machine for subpackaging, and the volume of each bottle is 0.5g or 1.0g (both in effective Amoxicillin component C16 h 19 N 3 o 5 S), wherein, 0.5g is subpackaged with 7-12mL vials, and 1.0g is subpackaged with 15-25mL vials.

[0030] All steps...

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Abstract

The invention discloses a painless synergistic amoxicillin powder injection for animals. The powder injection is prepared from, by weight, 48-52 parts of amoxicillin or amoxicillin sodium, 10-30 parts of cosolvent, 1-3 parts of analgetic, 5-8 parts of probenecid sodium, 1-2 parts of heat-clearing anti-inflammation analgesic, 0.5-1 part of semen ziziphi spinosae extracts and 0.5-0.8 part of polygala root extracts. The analgetic is local anesthetic. The invention further discloses a preparation method of the painless synergistic amoxicillin powder injection for animals. The amoxicillin powder injection prepared through the method solves the problems that injection pricking and stress are strong, the anti-inflammation, pain-stopping and anti-fever effects are poor and appetite is reduced after administration, the demand for the product is large in clinical application, market prospects are wide, and social benefits are huge.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and relates to a painless and synergistic penicillin powder injection and a preparation method thereof, in particular to a veterinary painless and synergistic amoxicillin powder injection and a preparation method thereof. Background technique [0002] Amoxicillin and other penicillins are bactericidal β-lactam broad-spectrum antibiotics, which can kill a variety of Gram-positive and Gram-negative bacteria, and are one of the most widely used antibiotics in clinical practice. In human medicine, it is widely used in the form of tablets, powder injections, granules, powders, and capsules; in veterinary medicine, it is also used in powder injections, powders, tablets, and oily suspension injections. Amoxicillin is one of the antibiotics currently shared by humans and animals. [0003] At present, amoxicillin and other penicillins have relatively good application effects in veterinary medicine, and th...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K36/752A61K31/43A61K9/14A61P31/04A61K31/195A61K31/167A61K31/4458A61K31/445
Inventor 梁靖瑞
Owner 上海宥佳医药科技有限公司