A kind of veterinary painless synergistic amoxicillin powder injection and preparation method thereof
A technology of amoxicillin powder and amoxicillin, which is applied in powder delivery, active ingredients of heterocyclic compounds, active ingredients of ether/aldehyde acetals, etc., can solve the problem of increasing the working frequency and labor intensity of veterinarians, and the effect of antipyretic and antipyretic. Poor, head hitting the barn, jumping trembling, screaming and other problems, to achieve the effect of strengthening antibacterial and cough and asthma, saving medication costs and labor costs, and simple and reasonable process
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Embodiment 1
[0020] Preparation of veterinary painless synergistic amoxicillin powder injection: first, weigh various ingredients according to parts by weight, active ingredient amoxicillin: sodium carbonate: procaine hydrochloride: probenecid sodium: indomethacin : α-asarone (pre-powder finely passed through a 200-mesh sieve) is 50:30:2.5:6:3:1.0;
[0021] Then, 5 parts of amoxicillin, 5 parts of sodium carbonate, 1.0 part of α-asarone, 2.5 parts of procaine hydrochloride, 6 parts of probenecid sodium and 3 parts of indomethacin were put into SYH- In the 100 three-dimensional motion mixer, pre-mixed for 10 minutes, then dropped into 45 parts of active ingredient amoxicillin (sterile powder for injection, in terms of active ingredient C16H19N3O5S, mass fraction is more than 85%) and 25 parts of sodium carbonate (assistant Solvent, sterile powder for injection, the mass fraction is more than 99%), mixed for 15 minutes to obtain veterinary painless synergistic amoxicillin powder injection; t...
Embodiment 2
[0025] The preparation of veterinary painless synergistic amoxicillin powder injection: first, weigh various ingredients according to the weight parts, the active ingredient amoxicillin sodium: sodium bicarbonate: procaine hydrochloride: probenecid sodium: fluoride Nisin meglumine: α-asarone (pre-powder finely passed through a 300-mesh sieve) is 50:15:2:7:2:0.7;
[0026] Then, 5 parts of amoxicillin sodium, 5 parts of sodium bicarbonate and 0.7 parts of α-asarone, 2 parts of procaine hydrochloride, 7 parts of probenecid sodium, 2 parts of flunixin meglumine Put it into the SYH-100 three-dimensional motion mixer, pre-mix for 10 minutes, and then add 45 parts of active ingredient amoxicillin sodium (sterile powder for injection, based on the active ingredient C16H19N3O5S, the mass fraction is more than 88%) and 10 parts Sodium bicarbonate (cosolvent, sterile powder for injection, the mass fraction is more than 99%), mixed for 15 minutes to obtain veterinary painless synergistic ...
Embodiment 3
[0030] Under the conditions of high temperature of 40°C and humidity of 75%±5%, the powder injections prepared in Examples 1 and 2 were subjected to 6-month accelerated test investigation, and the results are shown in Table 1.
[0031] Table 1 Accelerated test of veterinary painless synergistic amoxicillin powder injection
[0032]
[0033] Note: For the data of the test items in Table 1, refer to "National Standards Collection of Veterinary Drugs" - National Standards for Raising Local Standards of Veterinary Drugs (Edited by the Veterinary Drug Evaluation Center of the Ministry of Agriculture, published by China Agricultural Press), Volume 1 P195.
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