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Preparation method of sophora alopecuroides total alkaloid

A technology of sophora bean seeds and lye, which is applied in the field of preparation of total alkaloids of sophora bean seeds and the extraction of plant components, can solve the problems of biological and environmental hazards, high impurity content, low product purity, etc., and achieves low equipment requirements. , the effect of high yield and simple process

Inactive Publication Date: 2015-08-12
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the percolation method and water extraction method have low product purity, high impurity content, and a yield of less than 3%; the alcohol extraction method has a yield of 7-8%, but the preparation process uses benzene for extraction, which is very harmful
It can be seen that the total alkaloids of bitter bean seeds currently on the market are all extracted by chemical solvents and produced by refining methods. Most of them use highly toxic organic solvents such as benzene and chloroform, which are very harmful to organisms and the environment.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take the seeds of bitter beans and use a pulverizer to pulverize them to coarse powder, pre-soak them with 3 times the amount of 0.1% sulfuric acid for 120 minutes, and then extract them at 60°C, extract and hydraulically filter to obtain the filtrate; concentrate the filtrate under reduced pressure to a thick After the paste, add 95% ethanol of 2 times the thick paste, stir, stand, and filter to obtain the filtrate; concentrate the filtrate to recover the ethanol to obtain the concentrated solution; alkalinize with 10% sodium hydroxide solution to pH= 10. Extract with 1 times the amount of cyclohexane to obtain the cyclohexane layer and the alkaline water layer; after concentrating the cyclohexane layer, it is eluted on the alumina column with acetone solvent, and the eluent is collected to obtain the total of soy bean seeds. Alkali eluent: After the eluent is concentrated to a thick paste, it is placed in a vacuum decompression dryer and dried at 60° C. to obtain a soli...

Embodiment 2

[0023] Take the seeds of bitter beans and use a pulverizer to pulverize them to coarse powder, pre-soak them with 3 times the amount of 0.5% sulfuric acid for 90 min, then extract at 50°C, extract and hydraulically filter to obtain the filtrate; concentrate the filtrate under reduced pressure to a thick After the paste, add 80% ethanol of 2 times the thick paste, stir, stand, and filter to obtain the filtrate; concentrate the filtrate to recover the ethanol to obtain the concentrated solution; alkalinize with 10% sodium hydroxide solution to pH= 10. Extract with 1 times the amount of cyclohexane to obtain the cyclohexane layer and the alkaline water layer; after concentrating the cyclohexane layer, it is eluted on the alumina column with acetone solvent, and the eluent is collected to obtain the total of soy bean seeds. Alkali eluent: After the eluent is concentrated to a thick paste, it is placed in a vacuum decompression dryer and dried at 60° C. to obtain a solid powder of to...

Embodiment 3

[0025] Take the seeds of bitter beans and use a pulverizer to pulverize them to coarse powder, pre-soak them with 3 times the amount of 1% hydrochloric acid for 180 minutes, then extract at 40°C, extract and hydraulically filter to obtain the filtrate; concentrate the filtrate under reduced pressure to a thick After the paste, add 70% ethanol of 2 times the thick paste, stir, stand, and filter to obtain the filtrate; concentrate the filtrate to recover the ethanol to obtain a concentrated solution; alkalinize with 10% sodium hydroxide solution to pH= 10. Extract with 1 times the amount of cyclohexane to obtain the cyclohexane layer and the alkaline water layer; after concentrating the cyclohexane layer, it is eluted on the alumina column with acetone solvent, and the eluent is collected to obtain the total of soy bean seeds. Alkali eluent: After the eluent is concentrated to a thick paste, it is placed in a vacuum decompression dryer and dried at 60° C. to obtain a solid powder ...

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PUM

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Abstract

The invention discloses a preparation method of sophora alopecuroides total alkaloid. The preparation method is characterized by comprising the following steps: pulverization, acidification, extraction, condensation, alcohol precipitation, alkalization, lipophilic solvent extraction, alumina column elution, condensation, dissolution, and vacuum pressure-reduced drying to obtain dried sophora alopecuroides total alkaloid powder. The provided preparation method has the advantages of simple technology, safe operation, low equipment requirement, high practicality, low toxicity during the preparation process, high yield of sophora alopecuroides total alkaloid, and suitability for industrial production and application.

Description

technical field [0001] The invention relates to a method for extracting essential components of plants, in particular to a method for preparing total alkaloids of Sophora sophorae, belonging to the technical field of chemical extraction. Background technique [0002] Bitter bean seeds are the seeds of the perennial herbaceous leguminous plant Sophora genus Sophora. It tastes extremely bitter, cold in nature and poisonous. Sophora sophora seed total alkaloids are the total alkaloids extracted and concentrated from the medicinal plant Sophora sophora, which mainly contains 8 matrine, oxymatrine, sophocarpine, oxysophocarpine one, sophoramine, The pharmacological effects of sophoridine, aloperine and other alkaloids, and the total alkaloids of Sophora sophora: ①The effect on the central nervous system is reflected in sedative hypnosis, analgesia and cooling; ②The effect on the cardiovascular system is reflected in anti-arrhythmia Abnormal, positive inotropic effect, blood pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489
Inventor 季浩阚建伟徐娟
Owner JIANGSU TIANSHENG PHARMA
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