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Medicine composition

A technology of composition and medicine, applied in the field of medicine

Active Publication Date: 2015-08-19
北京安塞迩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when used in the treatment of acute conditions, these oral formulations cannot meet the clinical needs, and usually injectable formulations are beneficial

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0148] Embodiment 1: prepare terazosin freeze-dried powder injection

[0149] formula:

[0150] Terazosin: 1mg,

[0151] Mannitol: 50mg,

[0152] Acid-base regulator: use appropriate amount when necessary, and adjust the pH to the specified value in the following preparation method,

[0153] Water for injection: up to 1ml.

[0154] Preparation method:

[0155] (a) take by weighing the active ingredient and solid excipient of prescription quantity, add appropriate amount (65% of prescription full amount) water for injection, stir and make to dissolve,

[0156] (b) add activated carbon (0.1%) to the medicinal solution obtained in the previous step, stir (make adsorption for 15min), filter and decarbonize (after decarburization and filtration with a titanium rod with a pore size of 1um, then use a 0.45um polyethersulfone filter element to filter the liquid medicine coarse filtration);

[0157] (c) Add water for injection to the full amount of the prescription, stir eve...

Embodiment 2

[0161] Embodiment 2: prepare terazosin freeze-dried powder injection

[0162] formula:

[0163] Terazosin: 1mg,

[0164] Mannitol: 25mg,

[0165] Acid-base regulator: use appropriate amount when necessary, and adjust the pH to the specified value in the following preparation method,

[0166] Water for injection: up to 2.5ml.

[0167] Preparation method:

[0168] (a) Take by weighing the active ingredient and the solid auxiliary material of the prescription amount, add an appropriate amount (70% of the total amount of the prescription) water for injection, stir to dissolve,

[0169] (b) add activated carbon (0.15%) to the medicinal solution obtained in the previous step, stir (make adsorption for 10min), filter and decarbonize (after decarbonizing and filtering with a titanium rod with a pore size of 1um, and then use a 0.45um polyethersulfone filter element to filter the liquid medicine coarse filtration);

[0170] (c) Add water for injection to the full amount of ...

Embodiment 3

[0173] Embodiment 3: prepare terazosin freeze-dried powder injection

[0174] formula:

[0175] Terazosin: 1mg,

[0176] Mannitol: 500mg,

[0177] Acid-base regulator: use appropriate amount when necessary, and adjust the pH to the specified value in the following preparation method,

[0178] Water for injection: up to 5ml.

[0179] Preparation method:

[0180] (a) take by weighing the active ingredient and solid excipient of prescription quantity, add appropriate amount (60% of prescription full amount) water for injection, stir and make to dissolve,

[0181] (b) Add gac (0.05%) to the medicinal solution obtained in the previous step, stir (make adsorption for 20min), filter and decarbonize (after decarburization and filtration with a titanium rod with a pore size of 1um, then use a 0.45um polyethersulfone filter element to filter the liquid medicine coarse filtration);

[0182] (c) Add water for injection to the full amount of the prescription, stir evenly, measu...

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Abstract

The invention relates to a medicine composition. The medicine composition comprises terazosin and an excipient, wherein the excipient is selected from mannitol, lactose, sorbitol, xylitol, glucose, maltose, glycine, soluble dextrin, xanthan gum, gelatine, hydrolyzed gelatine, Arabic gum, pectin, guar gum, peach gum, tragacanth gum, acacia gum, sodium carboxymethylcellulose, polyvinylpyrrolidone, carbomer, hydroxy propyl cellulose, hydroxypropyl methyl cellulose, alginate or is a combination thereof, wherein the weight ratio of the terazosin to the excipient is 1: (10 to 1000). The invention further relates to a method for preparing the medicine composition. The medicine composition disclosed by the invention has the excellent properties shown in the description.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a class of compositions, in particular to a class of injectable compositions. Background technique [0002] Terazosin (Terazosin) is usually used clinically as its hydrochloride, and the specifications of tablets or capsules on the market include 1 mg, 2 mg and 5 mg. Terazosin hydrochloride can be used for the treatment of benign prostatic hyperplasia and also for the treatment of hypertension, either alone or in combination with other antihypertensive drugs such as diuretics or α1-adrenergic blockers. According to the existing clinical indications, the daily dosage of terazosin for adults usually ranges from 1 to 10 mg. Terazosin is used for the treatment of benign prostatic hyperplasia (BPH). The relief of symptoms of benign prostatic hyperplasia and the improvement of urine flow rate are related to the smooth muscle relaxation caused by blockade of α1-adrenergic receptors in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/517A61P13/08A61P9/12A61P7/10A61P13/10
CPCA61K9/19A61K31/517
Inventor 刘磊官清华
Owner 北京安塞迩生物科技有限公司
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