Belladonna extract and preparation method thereof

The technology of belladonna extract and pH value, which is applied in the field of medicine, can solve the problems of increasing production cost, not green and environmental protection, waste of resources and the like, and achieves the effects of good drug efficacy, broad economic benefits and simple operation.

Inactive Publication Date: 2015-08-19
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Generally, most of the extraction processes for belladonna use the percolation method to extract belladonna extract (belladonna extract, belladonna liquid extract), and a large amount of chlorophyll will be produced in the process, about 1000 kg of belladonna will produce about 23 kg Chlorophyll waste, the general practice in the prior art is to directly discard these wastes, but this method is not only not environmentally friendly, but also contains a certain amount of active ingredients in chlorophyll, and direct disposal will cause waste of resources. It increases the production cost, which is neither economical nor environmentally friendly

Method used

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  • Belladonna extract and preparation method thereof
  • Belladonna extract and preparation method thereof
  • Belladonna extract and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] The preparation method of belladonna extract is as follows:

[0031] 1) Weigh 1 kg of belladonna coarse powder, use ethanol with a mass percentage concentration of 85% as a solvent, first soak belladonna coarse powder with ethanol for 48 hours, and stir constantly to improve uniformity; then use 1-3ml / min speed Slowly percolate until the scopolamine alkaloids are gradually and completely leached out to obtain the initial eluent and collect it. The ethanol is recovered from the initial eluent at 60°C under reduced pressure. After cooling to room temperature, filter and evaporate the obtained filtrate to obtain the first thick paste ;

[0032]2) After the filtration operation, the remaining residue, that is, "chlorophyll" waste, is first diluted with water to obtain a liquid medicine, and then the dilute sulfuric acid solution is added while stirring continuously and its pH value is checked. When the pH value is acidic, the neutralization operation can be stopped , let i...

Embodiment 2

[0035] The preparation method of belladonna extract is as follows:

[0036] 1) Weigh 1 kg of belladonna coarse powder, use ethanol with a mass percentage concentration of 88% as a solvent, soak the belladonna coarse powder with ethanol for 48 hours, and keep stirring to improve the uniformity; then with a speed of 1-3ml / min Slowly percolate, after the scopolamine alkaloids are gradually leached out, the first eluent is obtained and collected, and the ethanol is recovered from the initial eluent at 60°C under reduced pressure, cooled to room temperature, filtered and the obtained filtrate is evaporated and concentrated at 70°C , add 10 times the mass of ethanol, stir evenly and percolate slowly at a rate of 1-3ml / min, obtain the filtrate and collect it, recover the ethanol under reduced pressure at 60°C, cool to room temperature, filter and obtain The filtrate was evaporated and concentrated at 70°C to obtain the first thick paste;

[0037] 2) After the filtration operation, t...

Embodiment 3

[0040] The preparation method of belladonna extract is as follows:

[0041] 1) Weigh 1 kg of belladonna coarse powder, use ethanol with a mass percentage concentration of 87% as a solvent, first soak belladonna coarse powder with ethanol for 48 hours, and keep stirring to improve uniformity; then use 1-3ml / min speed Slowly percolate, after the scopolamine alkaloids are gradually leached out, the first eluent is obtained and collected, and the ethanol is recovered from the initial eluent at 60°C under reduced pressure, cooled to room temperature, filtered and the obtained filtrate is evaporated and concentrated at 60°C , add 10 times the mass of ethanol, stir evenly and percolate slowly at a rate of 1-3ml / min, obtain the filtrate and collect it, recover the ethanol from the filtrate at 60°C under reduced pressure, cool to room temperature, and then add ethanol solvent After repeated percolation once in this way, finally filter and evaporate and concentrate the obtained filtrate...

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Abstract

The invention provides a preparation method of a belladonna extract. The preparation method comprises the following steps: (A) soaking coarse powder of belladonna herb in ethanol, percolating the coarse powder, filtering the percolate and carrying out evaporation concentration on the filtrate, thus obtaining first thick paste; (B) adding water to dilute residual substances after filtration, adjusting the PH value to acidity, then separating upper chlorophyll, collecting lower clear liquor, adjusting the PH value to alkalinity and concentrating the clear liquor, thus obtaining second thick paste; (C) mixing the first thick paste with the second thick paste, thus obtaining the belladonna extract. The content of atropine sulfate in the belladonna extract obtained by adopting the preparation method is between 9.8mg / ml and 10mg / ml. The belladonna extract has the advantages that the belladonna extract has good effects and high purity; all the indexes meet the corresponding requirements of the national formulary and even outclass the effects superior to the quality indexes stipulated in the formulary.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a belladonna extract and a preparation method thereof. Background technique [0002] Belladonna is a herbaceous plant in the nightshade family. The perennial herb native to Western Europe was later transplanted to North Africa, West Asia, North America and other places, and it was also introduced and cultivated in China. Its native place is the shady and humid area of ​​the mountain, and it grows in groups in the calcareous soil. It germinates in early spring, with a total length of 40-50 cm and a maximum height of 5 meters. The root is cylindrical, 5-15 mm in diameter, light grayish brown on the surface, with longitudinal wrinkles; the old root is woody, the fine root is easy to break, the cross section is flat, the cortex is narrow, off-white, the xylem is broad, brownish yellow, and the cambium ring pattern is obvious , the pith is hollow. Stems flat-cylindrical, 3-6mm in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81
Inventor 陈犁吕姗珊陈云刘勇曾博程唐桂英李建华
Owner 重庆希尔安药业有限公司
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