30 results about "Atropine sulphate" patented technology

The invention provides a method for improving the stability of a low-concentration atropine ophthalmic preparation. The method is characterized in that an atropine sulfate bulk drug has a total impurity content of no more than 0.25% and / or a single impurity content of no more than 0.05%. The invention also provides a method for preparing the ophthalmic preparation, the atropine ophthalmic preparation prepared by using the method, and an application of the atropine ophthalmic preparation in preparation of drugs used for preventing and / or treating visual defects.

The invention provides a synchronizing method of atropine sulphate. The method is characterized in that hydrolyzing methyl phenoxyacetate (II) is hydrolyzed to obtain a compound (III); the compound (III) and thionyl chloride are subjected to acylation reaction to obtain a compound (IV); the compound (IV) and 8-methyl-8-azabicyclo[3.2.1]oct-3-alchol are subjected to condensation reaction to obtain a compound (V); the compound (V) and paraformaldehyde are used for producing atropine (VI) under an alkaline condition; the atropine (VI) is salified under an acidic condition to obtain the atropine sulphate (I). The preparation method is simple in technology, high in yield, high in purity, low in monomer impurity and easy for industrial production.

The invention relates to a preparation prescription and a technology of a compound diphenoxylate tablet. Every ten thousand compound diphenoxylate tablets comprise the following raw and auxiliary materials: 25g of diphenoxylate hydrochloride, 0.25g of atropine sulphate, 152-168g of starch, 522.5-577.5g of lactose, 47.5-52.5g of calcium hydrogen phosphate, 76g-84g 40 percent (ml / ml) of ethanol and 6.65-7.35g of magnesium stearate. The compound diphenoxylate tablet has better dissolution rate and content homogeneity.

The invention relates to a compound diphenoxylate tablet, which comprises the following components in parts by weight: 25 parts of diphenoxylate hydrochloride, 0.25 parts of atropine sulfate, 140-150 parts of cornstarch, 490-500 parts of sugar powder, dextrin 40~45 parts, 7~40 parts of sodium carboxymethyl starch and 8~9 parts of magnesium stearate. The present invention also relates to a preparation method of the compound diphenoxylate tablet. The compound diphenoxylate tablet of the present invention has good dissolution rate and good drug uniformity in the tablet.

The invention relates to a measurement method for the content of atropine sulfate in traditional Chinese medicine suppository containing belladonna liquid extract. The invention solves the problem that only the existence of atropine sulfate in traditional Chinese medicine suppository containing belladonna liquid extract the traditional can be detected in the field of traditional Chinese pharmacy,and the content of the atropine sulfate cannot be detected. In the method, chromatograph conditions are controlled, comparison product and test article solutions are prepared, the comparison product solution and the test article solution are respectively absorbed, and the content of the atropine is measured by a high performance liquid chromatography method by adopting an external standard methodby using a liquid chromatograph. The content of the atropine can be precisely measured. The main peak and front and back separation effect is good, and the number of theoretical plates is high. The invention has important meaning for controlling the quality of the traditional Chinese medicine suppository.

The invention discloses a preparation method of atropine sulphate and solves the problem that an intermediate alpha-formoxyl phenylacetic acid tropeine is incompletely hydrolyzed in sulfuric acid and poor in hydrolysis effect in a single solvent, and an atropine crude product salt forming process is tedious in operation. The preparation method specifically comprises the following steps: I, adding potassium borohydride into a mixture containing alpha-formoxyl phenylacetic acid tropeine, alcohol and chloroform; II, adding an appropriate amount of water into the mixture and separating out an organic layer; III, distilling the organic layer to recover chloroform so as to obtain a faint yellow oily liquid; IV, adding acetone into the faint yellow oily liquid for freezing crystallization to obtain an atropine crude product; V, dropwise adding sulfuric acid into a solution containing the mixed solvent and the atropine crude product to adjust the pH of the solution to be greater than 4 but less than 7 at the temperature of 5 DEG C below zero to 10 DEG; VI, freezing the mixture overnight and crystallizing, filtering and drying to obtain atropine sulphate white crystals. The preparation method disclosed by the invention not only greatly improves the content and molar yield of the atropine sulphate crude product, but also lowers the cost to a great extent, and further has the characteristics of being simple and convenient to operate.

The invention belongs to the field of chemical synthesis, and in particular relates to a preparation method of atropine sulfate. First prepare tropin ester, then prepare atropine, then make salt to obtain atropine sulfate, and finally obtain the product through refining. In the process of preparing tropin ester, the reaction temperature is strictly controlled at 105-111°C, and the crystallization temperature is 0-5°C, so as to improve the yield of tropin ester. In the process of preparing atropine by reduction reaction, palladium carbon is used as a catalyst, and the reaction temperature is strictly controlled at 10-15° C. to effectively improve the product quality. Dilute the sulfuric acid by preparing it into a sulfuric acid ethanol solution, control its dropping rate, and ensure the stable quality of atropine sulfate.