Compound mequindox injection for animals and preparation method thereof

A technology of compound methaquine and methaquine, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of incomplete curative effect, achieve reliable curative effect, convenient use, and reduce local stimulating effect

Inactive Publication Date: 2009-03-11
陈建波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The dosage of the injection is accurate and the effect is reliable, unlike the oral medicine that may be

Method used

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  • Compound mequindox injection for animals and preparation method thereof
  • Compound mequindox injection for animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of veterinary compound acemethaquine injection, contains following components, all are parts by weight:

[0023] Acetomequine 3g, atropine sulfate 30mg, α-pyrrolidone 15g, N,N-dimethylformamide 50g, benzyl alcohol 15g, water for injection 20g;

[0024] The veterinary compound acetylmethaquine injection is prepared according to the following steps:

[0025] 1) Mix and dissolve 3 g of methaquine with 15 g of α-pyrrolidone, 50 g of N, N-dimethylformamide, and 15 g of benzyl alcohol to obtain 83 g of methaquine solution;

[0026] 2) Mix and dissolve 30 mg of atropine sulfate and 20 g of water for injection to obtain 20.03 g of atropine sulfate solution;

[0027] 3) Mix 83 g of the acemethaquine solution prepared in step 1) with 20.03 g of atropine sulfate solution prepared in step 2), stir evenly, and filter with an organic filter membrane of 0.45um to obtain the filtrate;

[0028] 4) The filtrate obtained in step 3) was sterilized at 121° C. and 0.15 mpa for 20 mi...

Embodiment 2

[0040] A kind of veterinary compound acemethaquine injection, contains following components, all are parts by weight:

[0041] Acetomequine 5g, atropine sulfate 20mg, α-pyrrolidone 20g, N,N-dimethylformamide 40g, benzyl alcohol 20g, water for injection 25g;

[0042] The preparation steps are the same as in Example 1.

Embodiment 3

[0044] A kind of veterinary compound acemethaquine injection, contains following components, all are parts by weight:

[0045] Acetomequine 4.5g, atropine sulfate 25mg, α-pyrrolidone 18g, N,N-dimethylformamide 45g, benzyl alcohol 17g, water for injection 22g;

[0046] The preparation steps are the same as in Example 1.

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Abstract

The invention relates to a compound maquindox injection for veterinary use and a preparation method thereof. The injection is made from maquindox, atropine sulfate, organic solvent and water. As a special compound preparation for veterinary use, the injection has special efficacy on severe diseases caused by treponema such as swine dysentery, piglet yellow dysentery, white dysentery, calf diarrhea, paratyphoid, bacterial enteritis, and the like, and has the advantages of convenient use, short treatment course, low drug resistance, and the like.

Description

technical field [0001] The invention relates to a veterinary compound methaquine injection, in particular to a compound preparation made of methaquine and atropine sulfate and a preparation method thereof. Background technique [0002] Acetylmethaquine (Meqnindox), also known as Shibajing, is a synthetic quinoxaline antibacterial drug with broad-spectrum antibacterial effect, and its effect on Gram-negative bacteria is stronger than that of Gram-positive bacteria, and it also has a stronger effect on Treponema . Its antibacterial mechanism is to inhibit the deoxyribonucleic acid (DNA) synthesis of bacteria. It is effective for piglet yellow scour, pullorum, calf diarrhea, paratyphoid fever, poultry pasteurellosis, chick pullorum, chicken colibacillosis, etc. It is mainly used for swine dysentery caused by Treponema, piglet yellow scour, pullorum, and also for Bacterial enteritis can also be used for calf diarrhea and paratyphoid fever. For example, the Chinese patent whos...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/498A61K31/46A61P31/00
Inventor 陈建波刘正芳
Owner 陈建波
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