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Chinese medicine composition with drug-dropping action, and its preparing method and quality control method

A quality control method and composition technology, applied in the field of pharmaceuticals, can solve problems such as failure to fully utilize traditional Chinese medicine, small effect, limited curative effect, etc.

Inactive Publication Date: 2006-08-02
929 BIOLOGICAL PRODS XIAMEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, more and more attention has been paid to the research and development of new drug detoxification drugs of traditional Chinese medicine, but the drugs currently on the market generally have little effect and are often only used for the detoxification treatment of patients with moderate or less drug dependence; some Chinese and Western medicines are used in combination , can not get rid of the use of opioid receptor agonists, due to the limited curative effect, the role of traditional Chinese medicine cannot be fully exerted

Method used

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  • Chinese medicine composition with drug-dropping action, and its preparing method and quality control method
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  • Chinese medicine composition with drug-dropping action, and its preparing method and quality control method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0046] Experimental Example 1: Rat urge withdrawal therapy test

[0047] The test is carried out in three steps.

[0048] First: establish a rat Mor body dependence model. Seventy-two SD rats, half ♂♀, were randomly divided into 6 groups according to body weight and sex, with 12 rats in each group, one of which was the NS group, and the other 5 groups were the Mor group. The Mor-dependent model was established by the dose escalation method, and the doses were administered according to Table 1. The NS group received s.c NS every day, and each Mor group was given s.c Mor three times a day (8:00, 14:00, 20:00).

[0049] drug

Dosage for each day (mg / kg / time)

Total (mg / kg)

d1-d2

d3-d4

d5-d6

d7-d15

Mor

5

10

20

30

960

[0050] Second: detoxification treatment. Starting from the 10th day, s.c Mor was administered at the same time as the treatment administration. The NS group was set as the control grou...

experiment example 2

[0056] Experimental Example 2: Rats Natural Withdrawal Treatment Test

[0057] The test is carried out in two steps.

[0058] First: establish a rat Mor body dependence model. Sixty SD rats, half ♂♀, were randomly divided into 6 groups according to body weight and sex, 10 rats in each group, one of which was the NS group, and the other 5 groups were the Mor group. Mor hydrochloride is administered by a dose escalation method, and the doses are administered according to Table 2. NS group s.c equal volume of NS, Mor group s.c twice a day (8:00, 16:00), continuous administration for 30 days, stop s.cMor on the 31st day.

[0059]

[0060] Second: detoxification treatment. From the 30th day, the body weight was weighed 3 times (8:00, 14:00 and 20:00) before administration every day for 8 consecutive days. The treatment and administration started on the 31st day. The NS group was set as the control group, and each Mor group was set as the Mor model group, the clonidine...

experiment example 3

[0064] Experimental example 3: monkey natural withdrawal treatment test

[0065] The test is carried out in two steps.

[0066] First: establish a monkey Mor body dependence model. Thirty ♂ monkeys were randomly divided into 6 groups according to body weight, 5 in each group. The 6 groups were 1 NS group and 5 Mor model groups. Mor hydrochloride was administered by dose escalation method, and the doses were administered according to Table 6. The NS group received i.m equal volume of NS, and the 5 Mor model groups received Mor i.m 3 times a day (8:00, 14:00, 20:00) for 90 consecutive days, and i.m Mor was stopped on the 91st day.

[0067]

drug

Dosage for each day (mg / kg / time)

total

(mg / kg)

d1-d7

d8-d14

d15-d21

d22-d28

d29-d90

Mor

3

6

9

12

15

3735

[0068] Second: detoxification treatment. Starting from the 90th day, the body weight was weighed twice a day (8:00, 16:00)...

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Abstract

The present invention discloses a Chinese medicine composition with the action of stopping drugs and its preparation method. It is made up by using the Chinese medicinal materials of ginseng, corydalis tuber, sea horse, dandelion, jinniucao, artificial bovine bezoar, datura flower and pearl according to a certain ratio. Said invention also discloses a quality control method of said Chinese medicine composition, including identification of tetrahydropalmatine, coffic acid, scopolamine and atropine, cholic acid and deoxycholic acid and content determination of ginsenoside Rg1, ginsenoside Re and scopolamine.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition with detoxification effect, a preparation method and a quality control method thereof. Background technique [0002] The drug problem is an international nuisance. The world's drug trade is worth 500 billion US dollars every year, second only to the arms trade. At least 48 million people in the world suffer from various drug addictions, and 100,000 people die every year. Addicts have distorted personality, abnormal behavior, infection, inflammation, and dysfunction of various body systems. Intravenous drug addicts are also a high-risk group and an important source of transmission for AIDS, venereal diseases, and various hepatitis. Once an addict discontinues the drug, the withdrawal symptoms occur sharply, and the pain is dangerous, and the overdose of the injection is more likely to lead to poisoning and death. It can be seen that its popular...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K36/69A61K36/66A61K36/288A61K36/258A61K35/56A61K35/413G01N30/02A61K35/618A61P25/36
Inventor 高学敏张建军黄泗滨闫旭东
Owner 929 BIOLOGICAL PRODS XIAMEN
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