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Application of a small molecular compound in anti-influenza virus drugs

A small molecular compound, anti-influenza virus technology, applied in the direction of antiviral agents, active ingredients of heterocyclic compounds, etc., can solve the problems of narrow antiviral spectrum, high mutation rate of HA and NA, and achieve the effect of broad anti-influenza virus activity

Active Publication Date: 2017-04-05
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, unlike antibiotics, antiviral drugs have a relatively narrow antiviral spectrum, while HA and NA have a high mutation rate, so continuous research and development of new anti-influenza drugs is an arduous and important task that requires constant persistence

Method used

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  • Application of a small molecular compound in anti-influenza virus drugs
  • Application of a small molecular compound in anti-influenza virus drugs
  • Application of a small molecular compound in anti-influenza virus drugs

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Experimental program
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Embodiment Construction

[0011] In order to better understand the essence of the present invention, the application of this antiviral compound against H1N1 subtype influenza will be described below in combination with experiments and results.

[0012] Experiment 1: Plaque Experiment of Antiviral Effect of Antiviral Compounds

[0013] 1) Prepare MDCK cells in a 24-well plate, and start the infection experiment when the cell density reaches about 80%-90%;

[0014] 2) Remove the supernatant medium of the 24-well cells, wash 1-2 times with PBS, and add the diluted virus infection solution;

[0015] 3) Prepare the cell culture medium. After 1 hour of infection, remove the virus infection solution, wash once with PBS, and add the cell culture medium containing the drug at a gradient dilution concentration.

[0016] 4) After 24 hours of infection, the supernatant of infected cells was collected for plaque assay. Prepare 12 wells of MDCK cells with a density above 90%. Take the supernatant of the infected ...

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Abstract

The invention protects application of a small molecule compound to anti-H1N1 influenza virus medicines. The compound provided by the invention has good anti-influenza virus effect, provides strong theoretical and practical foundation for further development of anti-influenza virus drugs, and has important research value and development significance.

Description

technical field [0001] The present invention relates to a new compound, more specifically, to an anti-influenza virus compound and its application. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus, especially influenza caused by influenza A virus is a zoonotic disease that seriously endangers domestic livestock and poultry and human health. It is highly pathogenic to humans and has repeatedly caused worldwide pandemics, causing huge economic losses and social panic in many countries and regions. [0003] Currently, the antiviral drugs against influenza produced on the market are mainly drugs targeting hemagglutinin (HA) and neuraminidase (NA) of influenza virus, such as zanamivir and Tamiflu. However, unlike antibiotics, antiviral drugs have a relatively narrow antiviral spectrum, while HA and NA have a high mutation rate, so continuous research and development of new anti-influenza drugs is an arduous and importan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61P31/18
Inventor 张辉张峻崧黄凤
Owner SUN YAT SEN UNIV