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A kind of method and technical process thereof for treating neopentyl glycol mother liquor in ibuprofen synthesis process

A technology for the mother liquor of neopentyl glycol and pentylene glycol, applied in the separation/purification of hydroxyl compounds, organic chemistry, etc., can solve the problems of difficult wastewater treatment, large proportion, and difficult secondary treatment of wastewater, and achieve water vapor saving The effect of reducing consumption, reducing production and running costs, and saving processing time

Active Publication Date: 2016-08-03
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Second, stripping method: the secondary treatment of the waste water steamed from the top of the stripping tower is difficult, and the waste water steamed from the top of the tower contains monochloromethane, dichloromethane, sherwood oil, water and a mass fraction of 1% to 2%. Neopentyl glycol, because neopentyl glycol has a higher boiling point than water and accounts for a large proportion of total COD, so neopentyl glycol in wastewater has caused difficulties for further treatment of wastewater

Method used

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  • A kind of method and technical process thereof for treating neopentyl glycol mother liquor in ibuprofen synthesis process

Examples

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Effect test

Embodiment 1

[0026] Implementation Example 1: The neopentyl glycol mother liquor flow rate is 3500 kg / h, after being preheated by the preheater, the temperature rises from 25.5°C to 76.4°C, and the temperature at the bottom of the rectification tower decreases from 121.6°C to 97.3°C. The driving steam pressure is 0.12Mpa, the flow rate is 2100kg / hour, the pressure of the fresh steam after compression is 0.51Mpa, and the temperature is 151.9°C. The quality of monochloromethane produced at the top of the stripper is 120.2 kilograms, the quality of dichloromethane is 119.1 kilograms, and the quality of petroleum ether is 90.0 kilograms. When the temperature at the top of the rectification tower reaches 103.7°C, stop driving the steam, compress the gas at the top of the rectification tower so that the pressure is 0.55Mpa, and the temperature is 155.5°C, then heat the stripping tower and the bottom reboiler of the rectification tower. The mass content of neopentyl glycol in the water extracted ...

Embodiment 2

[0027] Implementation Example 2: The neopentyl glycol mother liquid flow rate is 3700 kg / h, the temperature rises from 27.4°C to 72.2°C after being preheated by the preheater, and the temperature at the bottom of the rectification tower decreases from 108.1°C to 95.2°C. The driving steam pressure is 0.14Mpa, the flow rate is 2220 kg / h, the pressure of the fresh steam after compression is 0.52Mpa, and the temperature is 153.4°C. The quality of monochloromethane produced at the top of the stripper is 110.5 kilograms, the quality of dichloromethane is 124.5 kilograms, and the quality of petroleum ether is 94.1 kilograms. When the temperature at the top of the rectification tower reaches 104.8°C, stop driving the steam, compress the gas at the top of the rectification tower so that the pressure is 0.54Mpa, and the temperature is 154.8°C, then heat the stripping tower and the bottom reboiler of the rectification tower. The mass content of neopentyl glycol in the water extracted fro...

Embodiment 3

[0028] Implementation Example 3: The neopentyl glycol mother liquor flow rate is 5000 kg / h, after being preheated by the preheater, the temperature rises from 35.2°C to 75.1°C, and the temperature at the bottom of the rectification tower decreases from 126.2°C to 99.6°C. The driving steam pressure is 0.15Mpa, the flow rate is 3100kg / hour, the pressure of the fresh steam after compression is 0.58Mpa, and the temperature is 157.6°C. The quality of monochloromethane produced at the top of the stripper is 110.5 kilograms, the quality of dichloromethane is 124.5 kilograms, and the quality of petroleum ether is 94.1 kilograms. When the temperature at the top of the rectification tower reaches 104.1°C, stop driving the steam, compress the gas at the top of the rectification tower so that the pressure is 0.60Mpa, and the temperature is 158.9°C, then heat the stripping tower and the bottom reboiler of the rectification tower. The mass content of neopentyl glycol in the water extracted ...

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Abstract

The invention relates to a method for processing a neopentyl glycol mother liquor in an ibuprofen synthesis process. The method is characterized in the following steps: organics in the neopentyl glycol mother liquor are removed in a stripping tower; and the treated neopentyl glycol mother liquor is concentrated in a rectification tower. Reboilers are respectively arranged at the bottoms of the stripping tower and the rectification tower. A preheater is arranged at the bottom of the rectification tower, and two compressors and a condenser are arranged at the top of the rectification tower. A fresh material is heated by the preheater at the bottom of the rectification tower, and enters the stripping tower. The reboilers of the stripping tower and the rectification tower are first heated with driving steam, and then heated with the rectification tower top gas compressed by the compressor. With the process flow provided by the invention, monochloromethane, dichloromethane and petroleum ether in the neopentyl glycol mother liquor can be continuously removed, and neopentyl glycol can be concentrated.

Description

technical field [0001] The invention belongs to the separation field of the pharmaceutical industry, and in particular relates to a method for treating neopentyl glycol mother liquor in an ibuprofen synthesis process and a process flow thereof. Background technique [0002] Ibuprofen, also known as ibuprofen, is a white or off-white crystalline powder. It has anti-inflammatory, analgesic, and antipyretic effects, and is suitable for treating diseases such as rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and neuritis. Our country generally adopts the aryl 1,2-transposition rearrangement production process to synthesize ibuprofen. This process uses isobutylbenzene as the starting material, first carries out Friedel-Crafts acylation reaction with 2-chloropropionyl chloride, and then reacts with neopentyl The diol undergoes catalytic ketal reaction, and then undergoes catalytic rearrangement and hydrolysis reactions to finally produce finis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C31/20C07C29/76
CPCC07C29/76C07C31/20
Inventor 王英龙张震吴春霞刘薇卜光乐朱兆友
Owner QINGDAO UNIV OF SCI & TECH
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