Water-saving cooling type online washing method

A technology for cleaning and purifying water, applied in cleaning methods and utensils, chemical instruments and methods, cleaning hollow objects, etc., can solve the problems of increasing pharmaceutical costs, wasting water resources, and long cooling time, so as to shorten the cooling time and save water , to ensure the effect of cleaning effect

Active Publication Date: 2015-10-07
SHANDONG TAIBANG BIOLOGICAL PROD CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0003] The existing on-line cleaning system generally cools down by natural cooling or flushing with low-temperature injection water, but these methods have the following disadvantages: 1) Natural cooling is required after cleaning, and the cooling time is long due to the insulation layer in the reaction tank and pipelines. Too long; 2) Use cooled water for injection in the last step of cleaning, which will waste a lot of energy; 3) Use low-temperature water for injection to cool down after cleaning, which wastes a lot of energy and water resources , which increases the cost of pharmaceutical

Method used

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  • Water-saving cooling type online washing method

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Embodiment Construction

[0043] The technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0044] The parameters of each device are as follows:

[0045] 1 alkali tank (volume: 400L), 2 water tank (volume: 400L), 3 online conductivity meter Ⅰ (measurement range: 20-100mS / cm), 4 cleaning pump (flow rate: 10000L / h, head: 50m), 5 check valve, 6 pressure sensor Ⅰ, 7 vortex tube cooler, 8 pressure sensor Ⅱ, 9 temperature sensor Ⅰ, 10CIP circulation shut-off valve, 11 liquid return pump, 12 temperature sensor Ⅱ, 13 online conductivity meter Ⅱ (measuring range : 0-100μS / cm).

[0046] After the use of biological product reaction tanks and pipelines, in order to ensure the cleaning effect and cooling effect, the specific implementation steps are as follows:

[0047] Reaction tank cleaning after use

[0048] The first step, confirm before cleaning

[0049] 1) The control system judges the air supply pressure o...

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Abstract

The invention belongs to an online washing method used for the field of biological pharmacy, and particularly relates to a water-saving cooling type online washing method. The online washing method is used for cleaning and cooling of reaction tanks and pipes in the field of biological pharmacy. The water-saving cooling type online washing method is a full-automatic online washing method for the reaction tanks and the pipes. The water-saving cooling type online washing method includes the following steps: 1, affirming that washing conditions are met before washing is carried out; 2, carrying out washing through purified water; 3, carrying out blowing through compressed air; 4, carrying out washing through alkali liquor; 5, carrying out blowing through compressed air; 6, carrying out washing through water for injection; 7, carrying out blowing through low-temperature compressed air; 9, finishing. The defects of an existing online washing method are overcome; on the basis that the washing effect is guaranteed, the cooling time after washing is shortened, and meanwhile the aims of saving energy, reducing consumption and saving water can be achieved.

Description

technical field [0001] The invention belongs to an online cleaning method used in the field of biopharmaceuticals, and is used for cleaning and cooling reaction tanks and pipelines in the field of biopharmaceuticals. online cleaning method. Background technique [0002] Biological products are generally active substances and are usually sensitive to heat. Too high a temperature will lead to inactivation of the drug. The temperature of the product generally needs to be kept at 2-8°C or even lower during the production process. The clean state of pyrogens, in order to avoid bringing in microorganisms, pyrogens and other contaminated products, equipment and pipelines need to be washed with high-temperature water for injection at 80°C before and after each use to ensure the cleaning effect of reaction tanks and pipelines. [0003] The existing on-line cleaning system generally cools down by natural cooling or flushing with low-temperature injection water, but these methods have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B08B9/032B08B9/093B08B13/00
CPCB08B9/032B08B9/0328B08B9/093B08B13/00B08B2209/053B08B2209/08
Inventor 李斌李佐师秀梅郑志华孙丰斌
Owner SHANDONG TAIBANG BIOLOGICAL PROD CO LTD
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