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Diagnostic mirna markers for alzheimer

一种阿尔茨海默氏、-mir-161的技术，应用在新颖的标志物领域，能够解决有效、简易、可靠的诊断检验未满足等问题

Active Publication Date: 2015-10-14
SIEMENS HEALTHCARE GMBH
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  • Abstract
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  • Claims
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Problems solved by technology

[0009] Therefore, there remains an unmet need for an effective, simple, reliable diagnostic test for AD

Method used

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  • Diagnostic mirna markers for alzheimer
  • Diagnostic mirna markers for alzheimer
  • Diagnostic mirna markers for alzheimer

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Embodiment Construction

[0101] Further details, features, characteristics and advantages of the object of the present invention will be further disclosed in the following description and accompanying drawings of examples, which show preferred embodiments of the invention by way of example only. However, these examples should in no way be construed as limiting the scope of the invention.

[0102] The present invention relates to methods for diagnosing Alzheimer's disease using miRNA markers.

[0103] Diagnosis of Alzheimer's disease can be challenging in patients presenting with general age-related symptoms such as forgetfulness. In particular, the earliest stages of the disease are difficult to diagnose. However, a reliable diagnostic test for this disease stage is particularly needed, since the chances for therapeutic and social intervention are better during this early disease stage.

[0104] Herein, the abundance of miRNAs in blood samples of Alzheimer's disease patients has been compared in an ...

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Abstract

The invention relates to methods for diagnosing Alzheimer's Disease (AD) with miRNA markers. Diagnosis of AD Towards the identification of biomarkers for diagnosis of AD, a comprehensive analysis of miRNA expression patterns was obtained. Significantly deregulated miRNAs were identified.

Description

field of invention [0001] The present invention relates to novel markers for the diagnosis of Alzheimer's disease. Background of the invention [0002] Recently, the importance of molecular diagnostics has increased. It has found its way into the clinical diagnosis of disease (in particular, detection of infectious agents, detection of mutations in the genome, detection of diseased cells and identification of risk factors for disease predisposition). [0003] In particular, nucleic acid analysis opens up very promising new possibilities in the study and diagnosis of diseases by determining gene expression in tissues. [0004] Nucleic acids of interest to be detected include genomic DNA, expressed mRNA and other RNA such as microRNA (miRNA for short). miRNAs are a new class of small RNAs with multiple biological functions (A. Keller et al., Nat Methods. 20118(10):841-3). They are short (with an average of 20-24 nucleotides) ribonucleic acid (RNA) molecules found in eukaryo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68G16B30/00
CPCC12Q1/6809C12Q2600/178C12Q1/6883C12Q2600/158G16B30/00C12Q2600/118C12Q2600/16
Inventor A.凯勒C.F.斯塔勒E.米斯A.卡普尔C.巴克斯P.莱丁格
Owner SIEMENS HEALTHCARE GMBH
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