Medicine composition containing parietic acid and pharmaceutical purpose of medicine composition

A composition and technology of rhein, applied in the field of medicine, can solve problems such as the treatment of kidney diseases that have not been seen in combination with rhein

Inactive Publication Date: 2015-11-04
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although there have been research reports on the therapeutic effect of rhein, most of them are used for the treatment of diabetic nephropathy, and the reports of emodin are also mostly focused on the treatment of diabetic nephropathy. There are no reports on other diseases, not to mention the combination of rhein, emodin, chrysophanol and emodin methyl ether in the treatment of kidney disease

Method used

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  • Medicine composition containing parietic acid and pharmaceutical purpose of medicine composition
  • Medicine composition containing parietic acid and pharmaceutical purpose of medicine composition
  • Medicine composition containing parietic acid and pharmaceutical purpose of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Take 2.0g of rhein and 1.5g of emodin, add PEG-20050ml, add water for injection to dilute to 500ml, filter, add water for injection to 800ml, adjust the pH value to 6.5-7.0, add water for injection to dilute to 1000ml, and use 0.22 Filter through a μm microporous membrane, aliquot and sterilize to obtain an injection.

Embodiment 2

[0123] Take 200g of rhein, 150g of emodin, an appropriate amount of meglumine and arginine, add water for injection and dilute to 5L, stir until dissolved, filter, adjust the pH value of the filtrate to 5.0-7.0, and use a 0.22μm microporous membrane for purification. Filtration; take an appropriate amount of mannitol and add water for injection to prepare a solution, mix with the above filtrate, filter with a 0.22 μm microporous filter membrane, add water for injection to dilute to 10L, pack according to the dosage of 10ml of the unit preparation, freeze-dry to obtain frozen dry powder.

Embodiment 3

[0125] Take 62.5g of rhein, 46.9g of emodin, 0.6g of chrysophanol and emodin methyl ether, pre-crossed starch, micronized silica gel, magnesium stearate, and appropriate amount of talcum powder, pass through an 80-mesh sieve, and mix with the medicinal powder evenly. Add an appropriate amount of binder to make a soft material, granulate, and dry the granules at 60°C. Add micropowder silica gel, magnesium stearate and talcum powder, mix evenly, and press into 1000 tablets.

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Abstract

The invention relates to a medicine composition containing parietic acid and a pharmaceutical purpose of the medicine composition. The composition comprises the parietic acid and rheum emodin and can also comprise chrysophanol and emodin monomethyl ether. The composition can be made into preparations in a solid form, a liquid form, a gas form or a semi-solid form. A great number of experiments prove that the medicine composition can be used for treating kidney diseases, nephrotic syndrome, hypertensive nephropathy, cardiovascular and cerebrovascular diseases, tumor diseases and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing rhein and emodin for treating kidney diseases and its application. Background technique [0002] Rhein (Rhein, 4.5-dihydroxy anthraquinone) belongs to monoanthracene nucleus 1,8-dihydroxyanthraquinone derivatives, brown needle crystals, insoluble in water, soluble in pyridine, sodium bicarbonate aqueous solution, slightly soluble in ethanol, benzene , chloroform, ether and petroleum ether, molecular formula C15H8O6, mainly distributed in Polygonaceae plants, it is one of the main components of many traditional Chinese medicines such as rhubarb, Polygonum multiflorum, Polygonum cuspidatum, and leguminous, Scrophulariaceae plants also contain this component, Its medicinal source is abundant and easy to get. In recent years, studies have found that rhein has a wide range of pharmacological activities, such as liver protection, anti-fibrosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P13/12A61P9/12A61P35/00A61P9/00A61P9/10A61K31/122
Inventor 吴芳吕延英王光建赵兴詹芳王俊平贾诚曾艳龙
Owner XIAN SHIJISHENGKANG PHARMA IND
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