Preparation method of nanometer Chinese herbal medicine ultrafine powder

A technology of Chinese herbal medicine and ultra-fine powder, which is applied in the direction of medical formula, medical preparations containing active ingredients, powder delivery, etc. It can solve the problems of poor quick effect of drug effect, unfavorable raw material biological activity, and the impact of raw material biological activity. Achieve the effect of outstanding bioavailability and drug effect, improve bioavailability and drug effect, and save traditional Chinese medicine resources

Inactive Publication Date: 2015-11-11
上海善力健生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technical solution published in this patent needs to be used in combination with excipients, there is the intervention of foreign substances, and the temperature is high during preparation, which will affect the biological activity of the raw material, which is not conducive to greatly improving the biological activity of the raw material and may cause drug efficacy. The quick display effect is not good, needs further improvement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In production, the preparation method of the nanometer Chinese herbal medicine ultrafine powder of the present invention was used to carry out nanoscale ultrafine pulverization of precious medicinal herbs such as Cordyceps sinensis and Ganoderma lucidum, and carried out activity experiments. The specific experimental data are as follows:

[0023] Table 1 Regulatory effect of Cordyceps sinensis nanometer on immune activity before and after

[0024] group

[0025] Table 2 Regulatory effect of Ganoderma lucidum before and after the immune activity

[0026] group

[0027] As can be seen from the analysis of the test results in Table 1 and Table 2, the NK cell activity of Cordyceps sinensis nano ultrafine powder and Ganoderma lucidum nano ultrafine powder obtained by the preparation method of nano Chinese herbal medicine ultrafine powder of the present invention is obviously better than that of Cordyceps sinensis ordinary fine powder and Ganoderma lucidum ...

Embodiment 2

[0029] The present embodiment prepares the ultrafine powder of nano ganoderma lucidum, specifically comprises the following steps:

[0030] (1) Slicing and pulverizing the Ganoderma lucidum medicinal material to be processed, and then placing it in a freeze dryer for freeze-drying to obtain dry Ganoderma lucidum powder with a moisture content of <1%;

[0031] (2) Place the Ganoderma lucidum dry powder prepared in step (1) in a fully enclosed high-speed centrifugal ultrafine pulverizer for ultrafine pulverization, and adopt a gasification electrostatic separator to reclaim the Ganoderma lucidum fine powder with a particle diameter of <100nm, while the particle diameter The fine powder of Ganoderma lucidum ≥100nm is continuously circulated for superfine grinding until the dry powder of Ganoderma lucidum is completely pulverized to a particle size of <100nm, that is, nano-sized Ganoderma lucidum ultrafine powder is obtained.

[0032] Wherein, the particle size of Ganoderma lucidu...

Embodiment 3

[0035] The present embodiment prepares the ultrafine powder of nano ganoderma lucidum, specifically comprises the following steps:

[0036] (1) Slicing and pulverizing the Ganoderma lucidum medicinal material to be processed, and then placing it in a freeze dryer for freeze-drying to obtain dry Ganoderma lucidum powder with a moisture content of <1%;

[0037] (2) Place the Ganoderma lucidum dry powder prepared in step (1) in a fully enclosed high-speed centrifugal ultrafine pulverizer for ultrafine pulverization, and adopt a gasification electrostatic separator to reclaim the Ganoderma lucidum fine powder with a particle diameter of <100nm, while the particle diameter The fine powder of Ganoderma lucidum ≥100nm is continuously circulated for superfine grinding until the dry powder of Ganoderma lucidum is completely pulverized to a particle size of <100nm, that is, nano-sized Ganoderma lucidum ultrafine powder is obtained.

[0038] Wherein, the particle size of Ganoderma lucidu...

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Abstract

The invention relates to a preparation method of nanometer Chinese herbal medicine ultrafine powder. The preparation method comprises the following steps: (1) cutting to-be-processed Chinese medicinal herbs into slices, grinding, placing the obtained powder into a freeze dryer for free drying, and thus obtaining dry Chinese herbal medicine powder with water content being less than 1%; and (2) placing the dry Chinese herbal medicine powder prepared in the step (1) into a fully-closed high-speed centrifugation ultrafine grinder for ultrafine grinding, recovering the Chinese herbal medicine ultrafine powder with grain diameters being smaller than 100nm by adopting a vaporizing electro-static separator, carrying out ultrafine grinding circularly on the Chinese herbal medicine ultrafine powder with grain diameters being not smaller than 100nm till the dry Chinese herbal medicine powder is completely grinded into the Chinese herbal medicine ultrafine powder with grain diameters smaller than 100nm, and thus preparing the nanometer Chinese herbal medicine ultrafine powder. Compared with the prior art, the preparation method has the advantages that the technological conditions are simple, the operation is convenient, the economic cost is low, large-scale generation is facilitated, the activity of the prepared nanometer powder is obviously superior to that of common raw Chinese herbal medicine powder, and thus the effect of improving the efficacy of the medicine is achieved.

Description

technical field [0001] The invention belongs to the technical field of Chinese herbal medicine processing, and relates to a preparation method of nanometer Chinese herbal medicine superfine powder. Background technique [0002] Traditional Chinese medicine has made an indelible contribution to the survival and reproduction of the Chinese nation. Statistics show that 80% of people in the world use natural medicines as their basic health care means, and the global sales of herbal medicines including traditional Chinese medicine are growing at a rate of 10% per year, and the annual growth rate of herbal medicine markets in western developed countries has reached 20%. % or more, greatly exceeding the growth rate of chemicals. [0003] Nano Chinese herbal medicine refers to the important active ingredients, active parts, original medicines and compound preparations with a particle size of less than 100nm manufactured by nanotechnology. With the continuous penetration and influe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61K36/074A61K36/41A61K9/14
Inventor 许宏华韩超
Owner 上海善力健生物科技有限公司
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