Application of 4-methoxybenzyl alcohol in preparation of TRPM7 inhibitor drugs

A technology of methoxybenzyl alcohol and inhibitors, applied in the application field of 4-methoxybenzyl alcohol in the preparation of TRPM7 inhibitor drugs, achieving the effects of good clinical application prospects, improving survival rate, and reducing calcium ion concentration

Inactive Publication Date: 2015-11-25
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report that 4-methoxybenzyl alcohol inh

Method used

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  • Application of 4-methoxybenzyl alcohol in preparation of TRPM7 inhibitor drugs
  • Application of 4-methoxybenzyl alcohol in preparation of TRPM7 inhibitor drugs
  • Application of 4-methoxybenzyl alcohol in preparation of TRPM7 inhibitor drugs

Examples

Experimental program
Comparison scheme
Effect test

experiment example 14

[0022] Experimental example 14-Methoxybenzyl alcohol (MOBA) blocking effect on cortical neuron TRPM7 channel

[0023] 1 Experimental materials

[0024] 1.1 Experimental animals

[0025] Healthy SD rats, SPF grade, weighing 250-300g, provided by the Institute of Experimental Animals, Sichuan Academy of Medical Sciences, certificate number SCK (Sichuan) 2013-24. The embryos of gestational 18-19d rats were taken for experiments.

[0026] 1.2 Main reagents and materials

[0027] 2-APB, Gd, American Sigma Company; Methylthiazolyl tetrazolium bromide (MTT), dimethyl sulfoxide (DMSO), American Amresco Company; Sodium dithionite (Na 2 S 2 O 4 ), Shantou Xilong Chemical Co., Ltd.; Fluo-3 / AM, Actin antibody, BCA kit, Beyotime Biotechnology Research Institute; LTRPC7 antibody, Santacruz, USA; serum-free medium (B-27Serum-FreeSupplement), DMEM High glucose liquid medium, Invitrogen Company, USA; 4-methoxybenzyl alcohol (MOBA), Bailingwei Technology Co., Ltd.

[0028] 1.4 Main instr...

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PUM

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Abstract

The invention discloses application of 4-methoxybenzyl alcohol in the preparation of TRMP7 inhibitor drugs and further discloses application of 4-methoxybenzyl alcohol in the preparation of brain protection drugs. The 4-methoxybenzyl alcohol is capable of inhibiting expression of TRMP7 and is a TRMP7 inhibitor, capable of lowering concentration of calcium ions in nerve cells, increasing survival rate of the nerve cells and preventing and/or treating hypoxia-caused brain injuries; the 4-methoxybenzyl alcohol can be prepared into brain protection drugs to prevent and/or treat ischemic cerebrovascular diseases and has a promising clinical application prospect.

Description

technical field [0001] The invention relates to the use of 4-methoxybenzyl alcohol in the preparation of TRPM7 inhibitor drugs. Background technique [0002] Ischemic cerebrovascular disease (ICVD) is one of the diseases that seriously endanger human health. The pathological process of ICVD is relatively complex, in which calcium overload occupies a central position, intracellular calcium concentration ([Ca 2+ ]) is the last common pathway to cause nerve cell damage, so the research and development of calcium channel antagonists is one of the hot spots in the treatment of ischemic encephalopathy. TRPM7 (transientreceptorpotential, TRP) belongs to a class of cation channel proteins. TRPM7 channel is one of the family of transient receptor potential channels on the cell membrane, involved in the process of cell survival, proliferation and adhesion. Studies have found that after cerebral ischemia, TRPM7 channels are abnormally opened under the regulation of calcium ions and o...

Claims

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Application Information

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IPC IPC(8): A61K31/085A61P9/10A61P25/00
Inventor 解宇环林青柳弯
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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