Preparing method of nano-hydroxyapatite

A nano-hydroxyapatite and a technology for preparation steps are applied in the field of preparation of nano-hydroxyapatite, and can solve the problems of failing to meet nano-scale requirements, uneven particle size of hydroxyapatite, etc. The effect of reducing calcium ion concentration

Inactive Publication Date: 2017-12-15
周益铭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main technical problem to be solved by the present invention is to provide a kind of hydroxyapatite for the defect that agglomeration occurs in the preparation process of the common

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] Example 1

[0025] Weigh the birch bark and 10% sodium hydroxide solution at a mass ratio of 1:10, heat and boil for 3 hours, filter and separate to obtain the filter residue, and rinse with 10% citric acid solution and deionized water in turn 10min to obtain the pretreatment filter residue; in parts by weight, weigh 30 parts of the pretreatment filter residue, 20 parts of glucose, 5 parts of peptone, 5 parts of yeast powder, 2 parts of disodium hydrogen phosphate and 100 parts of distilled water into high-speed homogeneous dispersion In the machine, disperse and homogenize at 3000r / min for 20 minutes to obtain a dispersed slurry, which is placed in a high-temperature sterilization box and sterilized at 120°C for 30 minutes to obtain a sterilized slurry; put the sterilized slurry into a fermentation tank, Then add 10% of the sterilized slurry mass to the fermentation tank to a concentration of 10 6 cfu / mL Acetobacter xylinum suspension, seal the mouth of the tank, and ferm...

Example Embodiment

[0026] Example 2

[0027] Weigh the birch bark and 10% sodium hydroxide solution at a mass ratio of 1:10, heat and boil for 4 hours, filter and separate to obtain the filter residue, and rinse with 10% citric acid solution and deionized water in turn 13min, get the pretreatment filter residue; in parts by weight, weigh 35 parts pretreatment filter residue, 23 parts glucose, 8 parts peptone, 7 parts yeast powder, 3 parts disodium hydrogen phosphate and 130 parts distilled water into high-speed homogeneous dispersion In the machine, disperse and homogenize at a speed of 3500r / min for 25 minutes to obtain a dispersed slurry, which is placed in a high-temperature sterilization box and sterilized at 120°C for 32 minutes to obtain a sterilized slurry; put the sterilized slurry into a fermentation tank, Then add 10% of the sterilized slurry mass to the fermentation tank to a concentration of 10 6 cfu / mL Acetobacter xylinum suspension, seal the tank mouth, and ferment for 11 days at 40°C...

Example Embodiment

[0028] Example 3

[0029] Weigh the birch bark and the 10% sodium hydroxide solution at a mass ratio of 1:10, heat and boil for 5 hours, filter and separate the residue, and rinse with 10% citric acid solution and deionized water in turn 15min, get the pretreatment filter residue; in parts by weight, weigh 40 parts pretreatment filter residue, 25 parts glucose, 10 parts peptone, 8 parts yeast powder, 5 parts sodium hydrogen phosphate and 150 parts distilled water into high-speed homogeneous dispersion In the machine, disperse and homogenize at 4000r / min for 30 minutes to obtain a dispersed slurry, which is placed in a high temperature sterilization box and sterilized at 120°C for 40 minutes to obtain a sterilized slurry; put the sterilized slurry into a fermentation tank, Then add 10% of the sterilized slurry mass to the fermentation tank to a concentration of 10 6 cfu / mL Acetobacter xylinum suspension, seal the tank mouth, and ferment for 12 days at 45°C. Use tweezers to remove ...

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Abstract

The invention relates to the technical field of nano-material preparing, in particular to a preparing method of nano-hydroxyapatite. According to the preparing method, firstly birch bark fiber is decomposed through alkali boiling, later microorganism degradation intake is better facilitated, acetobacter xylinum is cultured, bacterial cellulose is obtained, and a calcium ion precursor is anchored to nano bacterial fiber; next, under the effect of ammonium hydroxide, phospholipid and lecithin are hydrolyzed, the hydrolysis product, calcium ions anchored to the surface of a bacterial cellulose template, nano-hydroxyapatite ions and hydroxyl groups are slowly combined to generate crystal nucleuses, as time passes, the crystal nucleuses gradually grow, the nanoscale space of the bacterial cellulose template can stop agglomeration of the nano-hydroxyapatite ions, by controlling the pH and adding citric acid, the purpose of lowering the concentration of calcium ions is achieved, the aqueous phase homogeneous precipitation kinetic constant is changed, in the in-situ crystallization process, nano-hydroxyapatite with a small size tends to be formed, and nano-hydroxy calcium phosphate is obtained after calcination. The preparing method of nano-hydroxy calcium phosphate is wide in application prospect.

Description

technical field [0001] The invention relates to the technical field of nanomaterial preparation, in particular to a method for preparing nano-hydroxyapatite. Background technique [0002] Hydroxyapatite is a multi-purpose inorganic material. Nano-hydroxyapatite is widely used in many fields due to its special properties such as small size effect and surface effect. In addition to its great application value in the field of biomedicine , There are also huge application potentials in the fields of oral health care, drug carriers, separation and purification, and industrial catalysis. [0003] There are many methods for preparing nano-hydroxyapatite powder, mainly including: solid-phase synthesis method, liquid-phase precipitation method, hydrothermal reaction method, sol-gel method, microemulsion method, simulated body fluid method, hydrolysis reaction method, self-assembly method , Self-combustion method, etc. In addition, there are electrochemical deposition, laser, ultraso...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00
Inventor 周益铭林茂兰
Owner 周益铭
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