In-vitro diagnostic device and kit

Abstract

The invention provides an infiltration detection device for predicting or detecting preeclampsia. The device comprises an enclosed shell, which is formed by an upper cover and a bottom groove, wherein the upper cover and bottom groove clamp and fix each other. In the enclosed shell, the upper cover is provided with a sample feed hole. A sample to be detected and other reagents such as coloring agent, eluent, and the like can be added into the shell through the sample feed hole. In the shell, from top to bottom, at least an infiltration layer and a water absorption layer are laminated. The infiltration layer comprises a micro-porous membrane, normal proteins and other micromolecular compounds can penetrate the micro-porous membrane, but protein aggregate which is mistakenly folded cannot penetrate the micro-porous membrane. The micro-porous membrane can be made of cellulose such as cellulose nitrate or cellulose acetate. Preferably, the micro-porous membrane in the infiltration layer comprises a labeling reagent, which can be specifically bound with mistakenly-folded protein aggregate, mistakenly-folded protein aggregate, or a mixture of the labeling reagent and mistakenly-folded protein aggregate.

Description

technical field [0001] The invention relates to disease diagnosis, especially a kit for diagnosing preeclampsia. Background technique [0002] Eclampsia (eclampsia) is a complex and dangerous disease that occurs in pregnant women after 20 weeks of pregnancy, especially in the third trimester. It is characterized by convulsions and coma, and is accompanied by major symptoms such as edema, hypertension, and proteinuria. May be complicated by renal failure, heart failure, pulmonary edema, cerebral hemorrhage, placental premature detachment, etc. Pre-eclampsia (also known as "pre-eclampsia") (pre-eclampsia) is before the seizures of eclampsia, headache, dizziness, upper abdominal discomfort, nausea and vomiting, chest tightness, blurred vision, golden eyes, anxiety, Symptoms such as irritability, which indicates the impending stage of eclampsia, are often accompanied by major symptoms such as hypertension and proteinuria. If blood pressure and proteinuria continue to increase o...

AI Technical Summary

Problems solved by technology

There are several defects in this diagnostic method: First, the timing of diagnosis is too late. Some patients have severe and dangerous symptoms of eclampsia at the time of diagnosis or shortly after diagnosis. Second, it is inaccurate. According to statistics, 38% of patients with eclampsia have no symptoms of hypertension or proteinuria; third, it cannot be applied to a large number of pregnant women: pregnant women who suffer from chronic hypertension, proteinuria, or kidney disease before pregnancy, And pregnant women who come for the first check-up after 20 weeks of pregnancy and do not know whether they have high blood pressure or proteinuria before

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