Experimental device for vascular intima injury in experimental animals

Abstract

The invention relates to the field of medical experimental equipment and particularly relates to a laboratory animal vascular intimal injury experimental facility. The laboratory animal vascular intimal injury experimental facility comprises a brush part and a handle part, wherein the brush part comprises a fixed assembly and bristles arranged on the outer peripheral surface of the fixed assembly or brush teeth arranged on the fixed assembly; the fixed assembly is connected with one end of the handle part; a diameter of the brush part is greater than or equal to an inner diameter of a vessel lumen of a laboratory animal and cannot be greater by 10 percent of the inner diameter of the vessel lumen of the animal at most. The laboratory animal vascular intimal injury experimental facility provided by the invention has a simple structure and is high in pertinence on an injured position; due to the case that the diameter of the brush part is slightly greater than or equal to the inner diameter of the vessel lumen, in the process that the brush part brushes back and forth inside the blood vessels, the bristles cannot damage a vascular intimal layer and hardly cause damage to a smooth muscle layer, so that interference of the smooth muscle layer to an experimental result is reduced.

Description

Technical field [0001] The invention relates to the field of medical experimental equipment, and in particular to an experimental device for vascular intimal damage in experimental animals. Background technique [0002] With the continuous development of my country's economic level and the continuous extension of life expectancy, cardiovascular and cerebrovascular diseases have surpassed cancer and become the number one killer threatening human health. Atherosclerosis is the main cause of cardiovascular and cerebrovascular diseases, and endometrial damage is An important pathogenesis of atherosclerotic disease. At present, in experimental studies related to vascular intima injury, researchers need to artificially injure the vascular intima of experimental animals, and then conduct research on the mechanism of vascular-related diseases. The above process is the production of experimental animal vascular intimal injury models. [0003] The blood vessel wall is mainly composed of thre...

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Problems solved by technology

[0004] However, since the intimal layer and the smooth muscle layer of blood vessels are closely connected, when the intimal layer is ruptured, the smooth muscle layer will also be subject to certain mechanical damage at the same time. Experimental effects observed solely due to intimal injury

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