Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of fluconazole dropping pill and preparation method thereof

A fluconazole dripping pill and the technology for the fluconazole dripping pill are applied in the field of fluconazole dripping pills and their preparation, and can solve the problems that the stability of injections is not as good as that of solid preparations, the solubility of fluconazole is poor, and it is inconvenient to carry and transport. Achieve the effect of improved dissolution rate and bioavailability, convenient use and round and smooth appearance

Active Publication Date: 2019-03-08
河南亚卫动物药业有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the dosage forms of fluconazole are mainly tablets, capsules, powder injections and injections. However, due to the poor solubility of fluconazole in water, the absorption and availability of tablets and capsules are limited. Low dosage, high dosage, easy to cause toxic and side effects; and although injection administration has quick effect and low dosage, it is easy to cause stress reaction to animals when it is used for animals, and the stability of injection is not as good as solid preparation, and it is inconvenient to carry and transport. Powder injections and injections often have obvious limitations when applied to animals

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of fluconazole dropping pill and preparation method thereof
  • A kind of fluconazole dropping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The prepared fluconazole dropping pills of the present embodiment, in terms of mass percentage, each material is composed as follows: 5% fluconazole, 40% polyethylene glycol 4000, 54.23% polyethylene glycol 6000, 0.5% Poloxamer, 0.2% Tween 80, 0.02% amaranth, 0.05% sodium saccharin.

[0028] The preparation method of the present embodiment fluconazole dropping pills specifically comprises the steps:

[0029] (1) To prepare a liquid base, mix the prescription amount of polyethylene glycol 4000, polyethylene glycol 6000 and poloxamer evenly, heat and melt to obtain a liquid base;

[0030] (2) Dissolving fluconazole to obtain a mixed drug solution, adding fluconazole to the liquid matrix in step (1), stirring until completely dissolved, to obtain a mixed drug solution;

[0031] (3) Adding auxiliary materials, adding Tween 80, food coloring amaranth and flavoring agent sodium saccharin to the mixed liquid in step (2);

[0032] (4) To prepare drop pills, drop the mixed sol...

Embodiment 2

[0036] The prepared fluconazole dropping pills of the present embodiment, in terms of mass percentage, each material is composed as follows: 10% fluconazole, 20% polyethylene glycol 8000, 68.5% polyethylene glycol 6000, 1% Poloxamer, Tween 80 0.4%, Sunset Yellow 0.03%, Aspartame 0.07%.

[0037] The preparation method of fluconazole dropping pills in this example refers to Example 1, and only the temperature of the mixed solution obtained in step (4) is adjusted to 84°C; the temperature of the coolant is 8°C.

Embodiment 3

[0039] The prepared fluconazole dropping pills of the present embodiment, in terms of mass percentage, each material is composed as follows: 15% fluconazole, 30% polyethylene glycol 4000, 52.3% polyethylene glycol 8000, 2.0% Poloxamer, 0.6% Tween 80, 0.02% Allura Red, 0.02% Tartrazine, 0.06% Sucralose.

[0040] The preparation method of fluconazole dropping pills in this example refers to Example 1, only adjusting the heat preservation condition of the mixed solution obtained in step (4) to 88°C; the temperature of the coolant to 6°C.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to a fluconazole dropping pill and a preparation method and application thereof. The fluconazole dropping pill is composed of, by mass, 5-20% of fluconazole, 0.5-3% of poloxamer, 0.2-0.8% of tween 80 and the balance polyethylene glycol. Compared with existing pure solid dispersion (fluconazole tablets), the fluconanole dropping pill has the advantages that drug dissolution speed and bioavailability are improved obviously; the preparation method is mature and simple, and the defects of difficulty in smashing and much dust in the preparation process of the solid dispersion (tablets) are overcome; the fluconazole dropping pill is round and smooth in appearance, and is more convenient and quicker to use and easier to swallow than the tablets; the fluconazole dropping pill is special in structure and more stable in character, and the defect that the solid dispersion (tablets) is prone to aging is overcome.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a fluconazole dropping pill and a preparation method thereof. Background technique [0002] Canine and feline fungal disease is a common skin disease of pets and a zoonotic disease, which has a serious impact on the health of animals and humans. The main fungi that cause skin lesions in infected dogs and cats are Trichophyton, Microsporum canis and Microsporum gypsumoid, etc. The infection sites are more common in the skin, coat, claws and toenails, and are mainly distributed in the front of the affected animals' bodies and lower extremities, infection symptoms are often manifested as severe itching, accompanied by desquamation, depilation, and crusting, and severe manifestations are large areas of depilation. Other fungi that cause mycosis in dogs and cats, such as Cryptococcus neoformans and Aspergillus, can enter the bodies of dogs and cats and other animals thro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4196A61K47/26A61P31/10A61P17/00
Inventor 吴胜耀郭芳茹张遂平苑青艳郭菊王菊萍刘冬梅王黎明马志愿
Owner 河南亚卫动物药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com