A highly antibacterial absorbable medical suture

An antibacterial and suture technology, which is applied in the field of medical sutures, can solve the problems of skin tissue inflammation, wound bacterial infection, etc., and achieve the effects of less drug resistance, increased smoothness, and increased mechanical properties

Active Publication Date: 2018-07-06
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a foreign body, the suture exists in the incision tissue, and it is easy to cause inflammation in the skin tissue. The sutured wound is easily infected by bacteria in the surrounding environment of the body. Therefore, it is necessary to provide a suture with antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A highly antibacterial absorbable medical suture, its raw materials include by weight: 120 parts of carboxymethyl chitosan, 20 parts of polyglycolic acid, 10 parts of hyaluronic acid, 6 parts of silk fibroin, 12 parts of salmon collagen, 1 part of glutaraldehyde, 4 parts of genipin, 1 part of mannitol, 2 parts of glycerin, 2 parts of paint;

[0026] Among them, the preparation method of the coating is: in an ice bath, add chitosan to concentrated sulfuric acid and stir to dissolve, dropwise add sorbyl chloride, stir at a speed of 300r / min for 3h, cool down to -10°C, keep warm for 12h, and dropwise add to In acetone, the filter cake was filtered, and dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to concentrated sulfuric acid was 1:40, and the weight ratio of chitosan to sorbyl chloride was 1.7:5; Use ammonia solution to adjust the pH of solution A to 8, filter, add ethanol, Soxhlet extraction for 24 hours, and vacuum dry t...

Embodiment 2

[0028] A highly antibacterial absorbable medical suture, its raw materials include by weight: 100 parts of carboxymethyl chitosan, 30 parts of polyglycolic acid, 6 parts of hyaluronic acid, 12 parts of silk fibroin, 8 parts of salmon collagen, 2 parts of glutaraldehyde, 2 parts of genipin, 3 parts of mannitol, 1 part of glycerin, 7 parts of paint;

[0029] Among them, the preparation method of the coating is: in an ice bath, add chitosan into concentrated sulfuric acid and stir to dissolve, add dropwise sorbyl chloride, stir at a speed of 100r / min for 5h, cool down to -20°C, keep warm for 24h, dropwise add to In acetone, the filter cake was obtained by filtration, and dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to concentrated sulfuric acid was 1:20, and the weight ratio of chitosan to sorbic acid chloride was 1.7:7.5; Use ammonia solution to adjust the pH of solution A to 6, filter, add ethanol, Soxhlet extraction for 36 hour...

Embodiment 3

[0031] A highly antibacterial absorbable medical suture, its raw materials include by weight: 105 parts of carboxymethyl chitosan, 28 parts of polyglycolic acid, 7 parts of hyaluronic acid, 10 parts of silk fibroin, 9 parts of salmon collagen, 1.7 parts of glutaraldehyde, 2.5 parts of genipin, 2.5 parts of mannitol, 1.2 parts of glycerin, 6 parts of paint;

[0032]Among them, the preparation method of the coating is: in an ice bath, add chitosan into concentrated sulfuric acid and stir to dissolve, add dropwise sorbyl chloride, stir at a speed of 150r / min for 4.5h, cool down to -18°C, keep warm for 20h, dropwise add into acetone, filtered to obtain a filter cake, dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to concentrated sulfuric acid was 1:25, and the weight ratio of chitosan to sorbic acid chloride was 1.7:6.5 ; adjust the pH of solution A to 6.5 with ammonia solution, filter, add ethanol, Soxhlet extraction for 32 hours, a...

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PUM

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Abstract

The invention discloses a highly antibacterial absorbable medical suture. The raw materials include: 100-120 parts of carboxymethyl chitosan, 20-30 parts of polyglycolic acid, hyaluronic acid 6‑10 parts of acid, 6‑12 parts of silk fibroin, 8‑12 parts of salmon collagen, 1‑2 parts of glutaraldehyde, 2‑4 parts of genipin, 1‑3 parts of mannitol, 1‑2 parts of glycerin, 2-7 parts of coating; Wherein, the preparation method of coating is: in ice bath, chitosan is added in the concentrated sulfuric acid and dissolves, and sorbyl chloride is added dropwise, stirs, and cooling, insulation, purification, obtains modified chitosan; The modified chitosan is dissolved in a mixed solvent to obtain a solution B; the temperature is raised, a silver nitrate solution is added, the mixture is kept stirring, a reducing agent is added dropwise, the mixture is kept stirred, and purified to obtain a coating. The invention has good antibacterial and anti-inflammatory properties and good mechanical properties.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to a highly antibacterial absorbable medical sutures. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, smooth wound after healing, but chitosan has poor mechanical properties and poor solubility. Carboxymethyl chitosan is a chitosan derivative with good water solubility and strong antibacterial properties. [0004] Nano-silver is a simple m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/14
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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