A highly antibacterial absorbable medical suture
An antibacterial and suture technology, which is applied in the field of medical sutures, can solve the problems of skin tissue inflammation, wound bacterial infection, etc., and achieve the effects of less drug resistance, increased smoothness, and increased mechanical properties
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Embodiment 1
[0025] A highly antibacterial absorbable medical suture, its raw materials include by weight: 120 parts of carboxymethyl chitosan, 20 parts of polyglycolic acid, 10 parts of hyaluronic acid, 6 parts of silk fibroin, 12 parts of salmon collagen, 1 part of glutaraldehyde, 4 parts of genipin, 1 part of mannitol, 2 parts of glycerin, 2 parts of paint;
[0026] Among them, the preparation method of the coating is: in an ice bath, add chitosan to concentrated sulfuric acid and stir to dissolve, dropwise add sorbyl chloride, stir at a speed of 300r / min for 3h, cool down to -10°C, keep warm for 12h, and dropwise add to In acetone, the filter cake was filtered, and dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to concentrated sulfuric acid was 1:40, and the weight ratio of chitosan to sorbyl chloride was 1.7:5; Use ammonia solution to adjust the pH of solution A to 8, filter, add ethanol, Soxhlet extraction for 24 hours, and vacuum dry t...
Embodiment 2
[0028] A highly antibacterial absorbable medical suture, its raw materials include by weight: 100 parts of carboxymethyl chitosan, 30 parts of polyglycolic acid, 6 parts of hyaluronic acid, 12 parts of silk fibroin, 8 parts of salmon collagen, 2 parts of glutaraldehyde, 2 parts of genipin, 3 parts of mannitol, 1 part of glycerin, 7 parts of paint;
[0029] Among them, the preparation method of the coating is: in an ice bath, add chitosan into concentrated sulfuric acid and stir to dissolve, add dropwise sorbyl chloride, stir at a speed of 100r / min for 5h, cool down to -20°C, keep warm for 24h, dropwise add to In acetone, the filter cake was obtained by filtration, and dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to concentrated sulfuric acid was 1:20, and the weight ratio of chitosan to sorbic acid chloride was 1.7:7.5; Use ammonia solution to adjust the pH of solution A to 6, filter, add ethanol, Soxhlet extraction for 36 hour...
Embodiment 3
[0031] A highly antibacterial absorbable medical suture, its raw materials include by weight: 105 parts of carboxymethyl chitosan, 28 parts of polyglycolic acid, 7 parts of hyaluronic acid, 10 parts of silk fibroin, 9 parts of salmon collagen, 1.7 parts of glutaraldehyde, 2.5 parts of genipin, 2.5 parts of mannitol, 1.2 parts of glycerin, 6 parts of paint;
[0032]Among them, the preparation method of the coating is: in an ice bath, add chitosan into concentrated sulfuric acid and stir to dissolve, add dropwise sorbyl chloride, stir at a speed of 150r / min for 4.5h, cool down to -18°C, keep warm for 20h, dropwise add into acetone, filtered to obtain a filter cake, dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to concentrated sulfuric acid was 1:25, and the weight ratio of chitosan to sorbic acid chloride was 1.7:6.5 ; adjust the pH of solution A to 6.5 with ammonia solution, filter, add ethanol, Soxhlet extraction for 32 hours, a...
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