Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM and complications

A ribonucleic acid, non-coding technology, applied in the field of invention of diabetes drug use, can solve the problem of not much research on long non-coding RNA and so on

Active Publication Date: 2015-12-09
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, breakthroughs have been made in the research of non-coding RNAs (such as microRNA, siRNA and piRNA) with a length of less than 50 nucleotides, but there are not many studies on functional long non-coding RNAs

Method used

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  • Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM and complications
  • Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM and complications
  • Application of long non-coding RNA uc.48+ small interfering RNA to preparation of medicine for treating DM and complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The oral or injectable long non-coding ribonucleic acid uc.48+ small interfering ribonucleic acid preparation suitable for the treatment of diabetes complicated diseases is prepared by methods known in the art.

Embodiment 2

[0017] Using methods known in the art, the preparation of oral or injectable long noncoding ribonucleic acid uc.48+ small interfering ribonucleic acid preparations suitable for the treatment of diseases mediated by glucokinase (GK) is prepared.

Embodiment 3

[0019] Using methods known in this technical field, it is prepared to be suitable for use in the preparation of diagnostic markers for the treatment of diabetes-related diseases or long non-coding ribonucleic acid uc.48+ dysfunction-related diseases.

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Abstract

The invention relates to application of long non-coding RNA (Ribonucleic Acid) uc.48+ small interfering RNA to preparation of medicine for treating DM (Diabetes Mellitus) and complications. In experiments, the conditions that the long non-coding RNA uc.48+ small interfering RNA can lower the raised blood sugar of a rat of a type 2 DM model and can improve the hepatic glycogen level are observed; and the GK (glucokinase) activity improvement is involved in the mechanism aspect. The long non-coding RNA uc.48+ small interfering RNA can also be applied to the preparation of medicine for treating GK function abnormity mediated diseases. The long non-coding RNA uc.48+ small interfering RNA can be used for preventing and treating the diseases as medicine in medicine preparations such as oral administration preparations, injection preparations, tablet preparations or other local or whole body available preparations.

Description

technical field [0001] The present invention relates to the field of the invention of the use of diabetes medicines. Background technique [0002] Diabetes Mellitus (DM) is a group of metabolic clinical syndromes. With the development of society and the improvement of people's living standards, the prevalence of diabetes increases year by year. In developed countries, the prevalence of diabetes has reached 3%-7%. It has become the fourth priority disease after cancer, AIDS, and cardiovascular and cerebrovascular diseases, and has become the fifth leading cause of death in the world. Diabetes is divided into type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes, whether it is type 1 (insulin-dependent) or type 2 (non-insulin-dependent) diabetes, the main symptom of which is hyperglycemia . Hyperglycemia is the leading cause of diabetes complications, and it is estimated that one in six people worldwide is at risk of developing diabetes complications. Type ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K31/713A61P3/10
Inventor 梁尚栋宋渺渺彭力超吴炳李桂林刘双梅高云徐宏吴红张春平
Owner NANCHANG UNIV
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