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A kind of traditional Chinese medicine composition for treating xerosis and preparation method thereof

A composition and technology for xerosis, applied in the field of traditional Chinese medicine, can solve the problems that have not been proven, affect the therapeutic effect of EGFRIs, and have short effective time

Active Publication Date: 2018-11-09
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the treatment of skin dryness and desquamation caused by EGFRIs, topical moisturizers have the disadvantage of short effective time, require multiple medications every day, and the burden on patients is heavy, and they cannot improve other dry symptoms of patients, such as dry mouth, dry throat, dry nose, Dry eyes, etc.; the mechanism of action of recombinant human epidermal growth factor spray and vitamin K is related to the blocking of EGFR downstream signals, whether it will affect the therapeutic effect of EGFRIs has not been confirmed
As a result, the reduction or withdrawal of EGFRIs often occurs, which seriously limits the clinical application of these drugs

Method used

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  • A kind of traditional Chinese medicine composition for treating xerosis and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating xerosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 Granules

[0058] Angelica 20g Rehmannia glutinosa 15g Scutellaria baicalensis 10g

[0059] Gentiana 10g Fangfeng 10g

[0060] Take the raw material according to the proportion, decoct twice with water, 1.5 hours each time, combine the decoction, filter, concentrate, dry under reduced pressure, use dextrin as the excipient, mix according to the ratio of drug to auxiliary 3:1, and mix well , made into particles.

[0061] In addition, the granule also has a good relief effect on other dryness symptoms caused by EGFRIs, such as dry mouth, dry throat, dry nose and dry eyes. In the clinical experiment, 10 malignant tumor patients with dry skin, dry mouth, dry throat, dry nose, and dry eyes were observed at the same time after the application of EGFRIs. They were treated with the granules for 14 days, and the effective standard was the symptom relief. Observe other clinical effects that the experimental example patient takes, and the effective rate of this gra...

Embodiment 2

[0062] Embodiment 2 Granules

[0063] Angelica 35g Rehmannia glutinosa 13g Scutellaria baicalensis 18g

[0064] Gentiana 8g Fangfeng 18g

[0065] Take the raw material drug in proportion, 70% ethanol ultrasonic extraction twice, the first 1 hour, the second 0.5 hour, combine the extract, filter, concentrate under reduced pressure, the extract uses dextrin as an excipient, and is assisted by medicine. Mix at a ratio of 3:1, mix well, make granules, dry, and get it.

Embodiment 3

[0066] Embodiment 3 granules

[0067] Angelica 15g Rehmannia glutinosa 30g Scutellaria baicalensis 7g

[0068] Gentiana 20g Fangfeng 7g

[0069] Take the raw material medicine in proportion, add water and reflux to extract twice, each time for 1.5 hours, combine the decoction, filter, concentrate, add 60% ethanol solution for alcohol precipitation, let stand, filter, concentrate, dry under reduced pressure, and use dextrin as excipient The excipient is mixed according to the ratio of drug to auxiliary 3:1, mixed evenly, made into granules, dried, and acquired.

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Abstract

The invention provides a traditional Chinese medicine composition for treating xerosis. The traditional Chinese medicine composition comprises the following crude drugs in parts by weight: 8-100 parts of angelica sinensis, 6-80 parts of radix rehmanniae preparata, 3-50 parts of scutellaria baicalensis, 3-50 parts of gentiana macrophylla and 3-50 parts of radix saposhnikoviae. The traditional Chinese medicine composition provided by the invention has a remarkable effect of relieving xerosis caused by EGFRIs and has no obvious adverse reaction.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for treating xerosis and its preparation method and application, belonging to the technical field of traditional Chinese medicine. Background technique [0002] In recent years, the clinical application of tumor targeted therapy has been increasing year by year, and its therapeutic effect is also increasing. It will soon become a promising tumor treatment method in the 21st century. Epidermal growth factor receptor inhibitors (EGFRIs) are the most widely used clinically at present. These drugs are favored by doctors and patients for their outstanding clinical efficacy. However, the skin toxicity caused by EGFRIs significantly affected their quality of life and reduced the compliance of treatment. [0003] Skin dryness and desquamation caused by EGFRIs mostly occurred at a later time...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P17/00
Inventor 崔慧娟
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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