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A kind of ileximide sustained-release preparation and preparation method thereof

A sustained-release preparation, hydroxypropyl methylcellulose technology, applied in the field of eleximide sustained-release preparations and its preparation, can solve the problems of poor patient compliance, inconvenient taking, and large fluctuations in blood drug concentration of ordinary tablets. To achieve the effect of reducing toxic and side effects, increasing compliance and increasing curative effect

Active Publication Date: 2019-02-19
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the following disadvantages: (1) It is inconvenient to take, and the patient's compliance is poor; (2) The therapeutic window of antiepileptic drugs is generally narrow, and the blood drug concentration of ordinary tablets fluctuates greatly, and the blood drug concentration is too high, especially when the patient is a child. Toxic and side effects, the blood concentration is too low to achieve the ideal curative effect; (3) The total dosage of ordinary tablets is relatively large, especially for children, the potential risk of harm is great

Method used

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  • A kind of ileximide sustained-release preparation and preparation method thereof
  • A kind of ileximide sustained-release preparation and preparation method thereof
  • A kind of ileximide sustained-release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prescription (1000 tablets):

[0028]

[0029]

[0030] Preparation Process:

[0031] 1) Crush all raw and auxiliary materials through a 60-80 mesh sieve

[0032] 2) Mix the ilexamine, sustained-release materials, regulated release materials, and filling materials evenly;

[0033] 3) Add binder to make soft material, granulate and dry;

[0034] 4) After sizing the dried granules, it is preferable to add lubricant, mix well, and compress;

[0035] 5) Then wrap it with a moisture-proof film coating, the coating will increase the weight by 2-3%, and it will be dried.

Embodiment 2

[0037] Prescription (1000 tablets):

[0038]

[0039] Preparation Process:

[0040] 1) Crush all raw and auxiliary materials through a 60-80 mesh sieve

[0041] 2) Mix the ilexamine, sustained-release materials, regulated release materials, and filling materials evenly;

[0042] 3) Add binder to make soft material, granulate and dry;

[0043] 4) After sizing the dried granules, it is preferable to add lubricant, mix well, and compress;

[0044] 5) Then wrap it with a moisture-proof film coating, the coating will increase the weight by 2-3%, and it will be dried.

Embodiment 3

[0046] Prescription (1000 tablets):

[0047]

[0048] Preparation Process:

[0049] 1) Crush all raw and auxiliary materials through a 60-80 mesh sieve

[0050] 2) Mix the ilexamine, sustained-release materials, regulated release materials, and filling materials evenly;

[0051] 3) Add binder to make soft material, granulate and dry;

[0052] 4) After sizing the dried granules, it is preferable to add lubricant, mix well, and compress;

[0053] 5) Then wrap it with a moisture-proof film coating, the coating will increase the weight by 2-3%, and it will be dried.

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PUM

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Abstract

The invention provides an ilepcimide sustained release preparation and a preparation method thereof. The ilepcimide sustained release preparation comprises the following components in mass percentage: 10-60% of ilepcimide, 30-85% of sustained-release material, 0-10% of adjusting drug release material, 0-3% of an adhesive, 5-20% of a filler, 0-2% of a lubricant and 0-5% of a coating material. The ilepcimide sustained release preparation can release a drug at a controlled rate to realize the purpose of releasing ilepcimide within about 24 hours by dosing the ilepcimide sustained release preparation once a day. The invention further discloses the preparation method of the ilepcimide sustained release preparation.

Description

Technical field [0001] The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sustained-release preparation of ilexamine and a preparation method thereof. Background technique [0002] Epilepsy is a chronic disease of the central nervous system and requires long-term medication. At present, the effective rate of anti-epileptic drugs used clinically is only 70% to 80%. Anti-epileptic drugs cannot prevent the formation of epileptic foci and the progression of the disease, but can only relieve symptoms. In addition, there are many adverse reactions of antiepileptic drugs, involving multiple systems of the human body. Common adverse reactions include skin rash, dizziness, nausea, anorexia, abnormal mental behavior, abnormal liver and kidney function, endocrine system dysfunction, and lymphadenopathy. Moreover, patients with epilepsy often need to take long-term medication or take several anti-epileptic drugs at the same time, which can aggra...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4525A61K47/38A61K47/32A61K47/10A61K9/28A61K9/52A61P25/08
Inventor 易斌安明榜石晓东
Owner 北京斯利安药业有限公司
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