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Application of pharmaceutical composition containing folium artemisiae argyi in preparing medicine for treating diabetic nephropathy

The technology of a composition and a medicine is applied in the field of preparing medicines for treating diabetic nephropathy, which can solve the problems of not very significant effect, and achieve the effects of better medicine treatment effect, good treatment effect and high marked efficiency.

Inactive Publication Date: 2016-02-10
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pharmaceutical composition has the effects of nourishing qi and nourishing yin, clearing away heat and dampness, promoting blood circulation and dredging collaterals, but the effect of the pharmaceutical composition on lowering blood sugar, invigorating the kidney and invigorating the spleen is not very significant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The pharmaceutical composition involved in the present invention comprises the following raw materials in parts by weight: 18 parts of Artemisia argyi, 15 parts of Gastrodia elata, 13 parts of corn silk, 10 parts of bitter melon seeds, 8 parts of ginseng leaves, 7 parts of A. chinensis, 5 parts of Alisma, and Chuanxiong 5 parts, 8 parts yam, 5 parts epimedium, 5 parts scutellaria and 7 parts licorice.

[0039] The preparation method is as follows:

[0040] A) Weigh mugwort leaves, pulverize, pass through a 100-mesh sieve, add 7 times its weight in water, soak for 0.5h, extract by steam heating for 2 times, 2 hours each time, filter, combine the filtrates to obtain mugwort leaf extract, keep Artemisia argyi dregs;

[0041] B) Weigh Gastrodia elata, pulverize it, pass it through a 100-mesh sieve, add 6 times its weight in an ethanol solution with a volume fraction of 75%, soak for 12 hours, and ultrasonically extract twice at 50°C for 2 hours each time, the ultrasonic fr...

Embodiment 2

[0046] 25 parts of mugwort leaves, 20 parts of gastrodia elata, 18 parts of corn silk, 17 parts of bitter melon seeds, 15 parts of ginseng leaves, 12 parts of sea ginseng, 12 parts of Alisma, 12 parts of chuanxiong, 13 parts of yam, 10 parts of epimedium, 15 parts of skullcap and 13 servings of licorice.

[0047] The preparation method is similar to Example 1.

Embodiment 3

[0049] The pharmaceutical composition involved in the present invention includes the following preparation materials in parts by weight: 22 parts of Artemisia argyi, 18 parts of Gastrodia elata, 15 parts of corn silk, 15 parts of bitter melon seeds, 12 parts of ginseng leaves, 10 parts of Acanthopanax ginseng, 8 parts of Alisma, and Chuanxiong 10 parts, 10 parts yam, 7 parts epimedium, 9 parts scutellaria and 9 parts licorice.

[0050] The preparation method is similar to Example 1.

[0051] The therapeutic effect of the pharmaceutical composition of the present invention on diabetic nephropathy rat model

[0052] 1. Prepare the model

[0053] Select 40 healthy male adult SD rats, weighing 0.35kg-0.4kg, fed with high-fat diet and unlimited water intake. Rats were subjected to unilateral kidney ligation and intraperitoneal injection of streptozotocin. Before the operation, the rats were fasted for 12 h and injected with sodium pentobarbital solution for anesthesia. After c...

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Abstract

The invention belongs to the field of a traditional Chinese medicine, and relates to application of a pharmaceutical composition containing folium artemisiae argyi in preparing a medicine for treating diabetic nephropathy. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 18-25 parts of folium artemisiae argyi, 15-20 parts of rhizoma gastrodiae, 13-18 parts of corn stigma, 10-17 parts of balsam pear seeds, 8-15 parts of folium ginseng, 7-12 parts of oplopanax elatus nakai, 5-12 parts of rhizoma alismatis, 5-12 parts of ligusticum wallichii, 8-13 parts of rhizoma dioscoreae, 5-10 parts of herba epimedii, 5-15 parts of scutellaria baicalensis and 7-13 parts of liquorice root. The pharmaceutical composition disclosed by the invention is reasonable in prescription and strong in synergistic effect; and the pharmaceutical composition, on treating the treating diabetic nephropathy, achieves a quite significant effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the use of a medicinal composition containing leaves of mugwort in the preparation of medicines for treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy, namely diabetic glomerulosclerosis, is one of the most typical microvascular complications of diabetes. As the disease progresses, it will lead to renal failure and is one of the most important causes of death in diabetes. Diabetic nephropathy is similar to "kidney elimination" recorded in TCM literature, and "turbid urine", "edema", "fullness" and "off grid" secondary to diabetes. In the early and middle stages, proteinuria and edema are often the main manifestations, while in the late stage of renal failure patients may manifest as fullness, vomiting, etc. This is due to the long-term deficiency of thirst, damage to the kidney body, loss of function of the kidney,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P13/12A61P3/10A61K36/282
Inventor 王一飞利奕成任哲刘秋英
Owner JINAN UNIVERSITY
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