Traditional Chinese medicine effervescent tablets for treating gynecologic inflammations and preparation method thereof

A technology for gynecological inflammation and effervescent tablets, which can be used in medical formulas, medical preparations containing active ingredients, antipyretics, etc. It can solve problems such as high cost, inconvenient transportation and storage, and inability to extract them, so as to achieve high utilization rate The effect of increasing and improving drug efficacy and reducing production cost

Inactive Publication Date: 2016-03-02
ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are certain defects in the above-mentioned preparation process. For example, the yellow lotus in the prescription is fried and extracted with more than 2 times the amount of sesame oil in the same pot. The components such as flavescens are effectively extracted, and the water-soluble components of Sophora flavescens, which have antibacterial and anti-inflammatory effects, are not utilized, so the therapeutic effects of Huanglian, Sophora flavescens and this formula cannot be fully utilized.
In addition, after extracting Huang Lian and Sophora flaves

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation of the medicated powder of embodiment 1 treatment gynecological inflammation

[0041] Raw material formula: Huanglian 248g, Sophora flavescens 100g, Patrinia 10g, Borneol 7g.

[0042] Preparation method: (1) Take Huanglian and Sophora flavescens, extract 3 times with 88% ethanol, each time for 2 hours, filter, and use the dregs for later use, add β-cyclodextrin 60g, PVPk to the filtrate 30 60g and poloxamer 10g, mix well, recover ethanol under reduced pressure, and obtain the concentrated solution of alcohol extraction; take the dregs of the medicine and add water to decoct 2 times, each time for 1.5 hours, filter, and the filtrate is centrifuged at high speed, and the centrifugate is concentrated to a relative density of 1.23( 60°C), combined with the alcohol extraction concentrate, spray-dried and pulverized to obtain the extract powder of Huanglian Sophora flavescens;

[0043] (2) Take borneol, 56g of β-cyclodextrin, and refer to the method [So...

Embodiment 2

[0046] The preparation of the medicated powder of embodiment 2 treatment gynecological inflammation

[0047] Raw material formula: Huanglian 210g, Sophora flavescens 120g, Patrinia 12g, Borneol 8g.

[0048] Preparation method: (1) get Huang Lian, pulverize into coarse powder, sterilize, and superfinely pulverize into ultrafine powder with a particle diameter≤10um to obtain Huanglian superfine powder;

[0049] (2) Take Sophora flavescens, extract 2 times with 95% ethanol, each time for 2.5 hours, filter, and the dregs are for subsequent use, and the filtrate is added with PVPk 30 70g, 30g of hydroxypropyl methylcellulose (HPMC-E5), 8g of soybean lecithin, stir well, recover ethanol under reduced pressure, concentrate to obtain alcohol extraction concentrate; take the dregs and add water to decoct twice, 1 hour each time , filtered, the filtrate was centrifuged at high speed, the centrifugate was concentrated to a relative density of 1.38, combined with the concentrated a...

Embodiment 3

[0052] The preparation of the medicated powder of embodiment 3 treatment gynecological inflammation

[0053] Raw material formula: Huanglian 218g, Sophora flavescens 110g, Patrinia 13g, Borneol 6g.

[0054] Preparation method: (1) get Huang Lian, pulverize into coarse powder, sterilize, and superfinely pulverize into ultrafine powder with a particle diameter≤10um to obtain Huanglian superfine powder;

[0055] (2) Take Sophora flavescens, extract 3 times with petroleum ether, each time for 1.5 hours, filter, use dregs for later use, combine filtrates, recover petroleum ether under reduced pressure, add PEG to the residue 6000 80g, 30g of hydroxypropyl-β-cyclodextrin, 5g of lecithin, 550ml of ethanol, after heating to reflux for 40min, recover ethanol under reduced pressure, freeze-dry, and crush at low temperature to obtain the fine powder of solubilized matter of Sophora flavescens fat-soluble extract; The dregs are decocted twice with water, each time for 1.5 hours, fi...

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Abstract

The invention discloses traditional Chinese medicine effervescent tablets for treating gynecologic inflammations. The traditional Chinese medicine effervescent tablets are composed of medicine powder, auxiliary materials playing the role of effervescence and other auxiliary materials, wherein the medicine powder for treating the gynecologic inflammations is mixed medicine powder prepared from goldthread roots, radix sophorae flavescentis, dahurian patrinia herb and borneol, the auxiliary materials playing the role of effervescence are composed of organic acid and carbonate, and other auxiliary materials are composed of one or more of filler, a bonding agent, a disintegrating agent and a lubricating agent. The invention further discloses a preparation method of the traditional Chinese medicine effervescent tablets. The prepared traditional Chinese medicine effervescent tablets for treating the gynecologic inflammations is good in stability and convenient to use, has the significant pharmacologic action of resisting bacteria and inflammations, relieving pain and inhibiting and killing trichomonas and has a good treating effect on the gynecologic diseases such as vaginitis, cervicitis, cervical erosion, pruritus vulvae and ulceration of vulvae.

Description

Technical field [0001] The invention belongs to the technical field of preparation of medicines, and in particular relates to a Chinese patent medicine for treating gynecological inflammatory diseases and a preparation method thereof. Background technique [0002] Gynecological inflammatory diseases such as adnexitis, pelvic inflammatory disease, vaginitis, cervicitis, cervical erosion, genital itching, and genital ulcers are common clinical diseases and frequently-occurring diseases. At present, there are many traditional Chinese medicine preparations for such diseases. However, due to factors such as slow or unstable curative effect, it still cannot meet the clinical needs. The variety "Fufuling Suppository" recorded in "Drug Standards of the Ministry of Health of the People's Republic of China" (eight volumes of traditional Chinese medicine preparations) is a suppository made from four traditional Chinese medicines: Huanglian, Sophora flavescens, Patrinia, and Borneol...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/46A61P15/02A61P15/00A61P17/04A61P17/02A61P29/00A61P33/02A61P31/04A61P31/10A61K31/045
CPCA61K36/718A61K9/0007A61K9/2027A61K9/2054A61K9/2059A61K9/2866A61K31/045A61K36/185A61K36/489A61K2236/331A61K2236/333A61K2236/35A61K2236/37A61K2236/39A61K2236/51A61K2236/53
Inventor 顾晓荣
Owner ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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