Detecting endocrine disrupting compounds
An endocrine disruptor, chemical compound technology, applied in analytical materials, biological tests, measurement devices, etc., can solve problems such as time increase, long diffusion path length, etc.
Inactive Publication Date: 2016-03-02
STELLENBOSCH UNIVERSITY
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- Claims
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Problems solved by technology
Despite the fact that these systems are widely used, they still have some disadvantages, including the need for large column assemblies and long diffusion path lengths, which in turn result in the need for the entire downstream processing from the introduction of the crude extract to the final purified product. significantly increased the time
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[0096] exist figure 1 A schematic diagram of the assay setup for the detection of endocrine disrupting compounds is shown in . The detection device comprises a support structure in the form of a membrane contactor and at least one ligand binding domain (LBD) of a sex hormone receptor immobilized on the support structure. The detection device also includes a linker molecule in the form of a modified PluronicMDDO between the support structure and the ligand binding domain.
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The invention relates to detecting endocrine disrupting compounds. Specifically the invention provides for a detection device for detecting endocrine disrupting compounds, which includes a support structure and ligand binding domains (LBD) of at least one sex hormone receptor, immobilised on the support structure. The detection device further includes a linker molecule between the support structure and the ligand binding domains, for immobilising the LBD's on the support structure.
Description
[0001] The present invention relates to the detection of endocrine disrupting compounds. In particular, the present invention relates to detection devices for detecting endocrine disrupting compounds and methods for detecting endocrine disrupting compounds. Background technique [0002] It is well known that certain hormonally active agents in the environment can interfere with the chemical messengers (hormones) of the endocrine system by sending false signals or blocking proper ones. Recognized hormone active agents, also known as endocrine disrupting compounds (EDCs), exert their deleterious effects in humans and wildlife by mimicking, blocking and interfering with the physiological functions of hormones. A 2009 comprehensive report by the Endocrine Society of America presents evidence that endocrine disruptors affect male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid activity, metabolism, obesity, and cardiovascular end...
Claims
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IPC IPC(8): G01N33/74C07K17/00C07K14/72
CPCC07K14/721C07K17/06G01N33/743G01N2333/723
Inventor P·斯瓦特B·E·特鲁博迪
Owner STELLENBOSCH UNIVERSITY