A kind of extraction recovery method of penicillin sulfoxide

Abstract

The invention discloses a method for extracting and recycling penicillin sulfoxide. The method comprises the following steps that a, a penicillin sulfoxide solution is subjected to impurity separation through resin absorption; b, a penicillin sulfoxide desorption solution is obtained through resin desorption; c, a penicillin sulfoxide crystallization solution is obtained through the mechanical application of dissolution penicillin sulfoxide to the penicillin sulfoxide desorption solution or concentration of the penicillin sulfoxide desorption solution; d, the pH of the crystallization solution is adjusted with acid for crystallization, and the penicillin sulfoxide is obtained through filtration, washing and drying. The method can be used for extracting and recycling the penicillin sulfoxide from the low concentration penicillin sulfoxide solution, and therefore the yield of the penicillin sulfoxide is increased, the production cost is reduced, and environmental pollution is reduced. The quality of subsequent products like 7ADCA, cefradine, cefalexin and cefadroxil prepared from the penicillin sulfoxide produced through the technology is improved. Pharmaceutical compositions formed by cefradine, cefalexin, cefadroxil and a medically acceptable carrier can be utilized for treating respiratory tract infection like acute tonsillitis, angina, tympanitis, nasosinusitis, bronchitis and pneumonia, urinary tract infection, skin soft-tissue infection and the like caused by sensitive bacteria.

Description

technical field

[0001] The invention belongs to the field of medicine and chemical industry, in particular to a method for extracting and recovering penicillin sulfoxide. Background technique

[0002] Penicillin sulfoxide is an important intermediate for the preparation of 7-amino-desacetoxycephalosporanic acid (7-ADCA), which is one of the two major nuclei of cephalosporin antibiotics , is an important precursor for the production of cephalosporins such as cephalexin, cefadroxil, and cephradine. Therefore, the production quality and yield of penicillin sulfoxide directly affect the production of cephalosporin antibiotics.

[0003] The preparation method of penicillin sulfoxide has following several at present:

[0004] 1. Penicillin industrial salt method:

[0005] a. The penicillin fermentation liquid is filtered and acidified and then extracted with butyl ester to obtain penicillin butyl ester extract (abbreviated as BA);

[0006] b. Alkalinization and back-extraction...