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Application of Spirooliganone A to preparation of drug for resisting tubercle bacilli

An anti-tuberculosis and tuberculosis technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of non-standard treatment and management of tuberculosis patients and difficulties in tuberculosis prevention and control.

Inactive Publication Date: 2016-04-20
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. However, due to the lack of standardized treatment and management of tuberculosis patients, irregular chemotherapy, and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be more diverse. Drug resistance at the same time, which has caused great difficulties in the prevention and control of tuberculosis

Method used

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  • Application of Spirooliganone A to preparation of drug for resisting tubercle bacilli
  • Application of Spirooliganone A to preparation of drug for resisting tubercle bacilli
  • Application of Spirooliganone A to preparation of drug for resisting tubercle bacilli

Examples

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Embodiment 1

[0013] Embodiment 1: the preparation of compound SpirooliganoneA tablet involved in the present invention:

[0014] Take 5 grams of the compound SpirooliganoneA, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of compound SpirooliganoneA capsules involved in the present invention:

[0016] Take 5 grams of the compound SpirooliganoneA, add 180 grams of starch, mix well, and pack into capsules to make 1000 capsules.

experiment example 1

[0017] Experimental Example 1: Determination of Absolute Concentration of SpirooliganoneA Against Bacillus Calmette-Guerin (BCG) by Solid Medium Dilution Method

[0018] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1). Turbidity, that is to make 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0019] SpirooliganoneA is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted SpirooliganoneA is added to 4ml Middlebrook7H11 agar medium according to the required dose (the culture base has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly to make Spirooliganone A, ...

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Abstract

The invention discloses application of Spirooliganone A to preparation of a drug for resisting tubercle bacilli. It is found that Spirooliganone A has remarkable activity in inhibiting tubercle bacilli and has a good application prospect. Since Spirooliganone A belongs to a brand new skeleton type and has high inhibitory activity to tubercle bacilli, Spirooliganone A has outstanding substantive advantages and has remarkable progress when applied to prevention and treatment of infection of tubercle bacilli.

Description

technical field [0001] The present invention relates to a new application of the compound Spirooliganone A, in particular to the application of the Spirooliganone A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. However, due to the lack of standardized treatment and management of tuberculosis patients, irregular chemotherapy, and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be more diverse. Drug resistance at the same time has caused great difficulties in the prevention and control of tuberculosis. Therefore, finding new anti-tuberculosis drugs, especially anti-multidrug resistance anti-tuberculosis drugs, is of great significance to protect people's health. [0003] The compound Spirooliganone A involved in the present invention is a new compound publis...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P31/06
CPCA61K31/352A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD