Compound of caulis dendrobii extract and iron and preparing method and application of compound

A technology of dendrobium extract and compound, which is applied in the directions of food ingredients, application and drug combination containing natural extracts, can solve problems such as the increase of FEP content, achieve strong treatment, reduce free protoporphyrin in red blood cells, and increase hemoglobin.

Active Publication Date: 2016-04-20
NANJING GENGFENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Iron-deficiency anemia, due to iron deficiency, protoporphyrin cannot combine with it to form he

Method used

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  • Compound of caulis dendrobii extract and iron and preparing method and application of compound
  • Compound of caulis dendrobii extract and iron and preparing method and application of compound
  • Compound of caulis dendrobii extract and iron and preparing method and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take 500g of Dendrobium officinale, crush it, add petroleum ether for depigmentation and degreasing, evaporate the petroleum ether, add 30 times of water, heat and extract for 2h, extract twice, centrifuge to obtain the centrifugal liquid, adjust the volume of the centrifugal liquid to a polysaccharide concentration of about 1%. The crude extract is obtained. Then add 4 times the volume of ethanol to the crude extract, precipitate by alcohol, centrifuge, add hot water to the resulting precipitate to dissolve the precipitate, add water to the same volume as the crude extract, and precipitate the protein by the TCA method (trichloroacetic acid method). After centrifugation, the centrifugal fluid is the Dendrobium officinale extract solution from which the protein has been removed, and the polysaccharide concentration measured is 0.87%.

[0033] Ferric chloride was added to the protein-removed Dendrobium officinale extract solution for iron complexation reaction. The steps a...

Embodiment 2

[0036] Take 500g of Dendrobium officinale, crush it, add petroleum ether for depigmentation and degreasing, evaporate the petroleum ether, add 30 times of water, heat and extract for 2h, extract twice, centrifuge to obtain the centrifugal liquid, adjust the volume of the centrifugal liquid to a polysaccharide concentration of about 1%. The crude extract is obtained. Then add 4 times the volume of ethanol to the crude extract, precipitate by alcohol, centrifuge, add hot water to the obtained precipitate, dissolve the precipitate, add water to the same volume as the crude extract, and obtain the Dendrobium officinale extract without removing the protein. The polysaccharide concentration is 1.10% and the protein concentration is 0.19%.

[0037] Ferric chloride was added to the extract of Dendrobium officinale without protein removal to perform iron complexation reaction. The steps are: adding 80% sodium citrate of the total mass of polysaccharides and proteins as a complexing agent...

Embodiment 3

[0040] Take 1500g of fresh Dendrobium officinale, add 10 times of water, beaten, heat and extract for 0.5 hours, extract twice, filter, add petroleum ether to extract depigmentation and degreasing, and centrifuge the resulting aqueous solution to obtain a centrifugal liquid. Adjust the volume of the centrifugal liquid to a polysaccharide concentration of about 1 %, the crude extract is obtained. Then add 4 times the volume of ethanol to the crude extract, precipitate by alcohol, centrifuge, add hot water to the obtained precipitate to dissolve the precipitate, add water to the same volume as the crude extract, and remove protein by the TCA method (trichloroacetic acid method). After centrifugation, the centrifugal fluid is the fresh Dendrobium officinale extract from which the protein has been removed, and the polysaccharide concentration is determined to be 1.01%.

[0041] Ferric chloride is added to the fresh Dendrobium officinale extract from which the protein has been removed...

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Abstract

The invention provides a compound of caulis dendrobii extract and iron and a preparing method and application of the compound. The compound comprises 100 parts of caulis dendrobii polysaccharide and 5-50 parts of iron, and can further comprise 5-20 parts of caulis dendrobii protein; the caulis dendrobii is medicinal caulis dendrobii in orchidaceae dendrobium. The preparing method of the compound includes the steps that a complexing agent is added into a water solution of the caulis dendrobii extract, a FeCl3 solution is added under the alkaline condition to be subjected to a complex reaction, centrifugalization, centrifugal liquid dialyzing and drying are carried out, and the compound is obtained. The compound, prepared with the preparing method, of the caulis dendrobii extract and the iron can be prepared into various dosage forms such as capsules, tablets, oral solutions and granules. According to an iron-deficiency-anemia pharmacological effect experiment and a clinical comparative experiment, the effect better than that of Niferex polysaccharide iron is obtained. The compound can be used for preparing medicine for preventing and treating iron-deficiency anemia, health-care products for preventing and treating iron-deficiency anemia or food additives for preventing and treating iron-deficiency anemia.

Description

Technical field [0001] The invention relates to a compound of a Chinese medicinal material extract and iron, in particular to a compound of a dendrobium extract and iron, and a preparation method and application thereof. Background technique [0002] Dendrobium is a precious traditional Chinese medicinal material in my country. It is listed as the top grade in the "Shen Nong's Materia Medica". It is known as the "life-saving fairy grass" in the folk. The Taoism includes Dendrobium, Snow lotus, Ginseng, Shouwu, Poria, Cistanche, Ganoderma lucidum, and Pearl Cordyceps sinensis is listed as "Nine Immortal Grasses of China". Among them, Dendrobium ranks first among the "Nine Immortal Grasses of China". Commonly known as medicinal gold, it is cold in nature, sweet, light, and slightly salty. It is born on a rock wall with a cluster of stems. Due to the depletion of wild resources, it was listed as a key protected wild medicinal species as early as 1987. It has the effects of nourishin...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K36/8984A61K38/02A61P7/06A61P3/02A23L33/00A23L33/105A23L33/165A61K33/26A61K31/295
CPCA23V2002/00A61K9/08A61K9/1652A61K9/2059A61K9/4866A61K31/295A61K31/715A61K33/26A61K36/8984A61K38/02A61K47/183A61K2236/331A61K2236/53A61K2300/00A23V2200/326A23V2250/21A23V2250/1592
Inventor 朱慧慧熊秀娟
Owner NANJING GENGFENG PHARMA TECH CO LTD
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