Gel adhesive bandage and preparation principle and preparation method thereof

Abstract

The invention discloses a gel adhesive bandage and belongs to the field of medical instruments. The gel adhesive bandage is characterized by being prepared from, by weight, 1-10 parts of hydroxypropyl chitosan, 1-60 parts of chitosan oligosaccharide, 0.1-10 parts of fructose and 20-500 parts of purified water; sodium hydroxide and hydroxypropyl chitosan need to be added when necessary. The gel adhesive bandage has the advantages of being easy and convenient to use, free of limitation by the position and size of a wound and easy to store, protecting and promoting wound healing, shortening healing time, resisting bacteria, stopping pain, inhibiting heaved scars caused by wound tissue dysplasia and fading purple pigmentation caused by wound tissue infection.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a gel bandage and its preparation principle and preparation method. Background technique [0002] Chitosan is the only alkaline polysaccharide among natural polysaccharides, but chitosan has poor water solubility and can only be dissolved in weak acids, but insoluble in water and many organic solvents, which limits its application to a large extent. Therefore, the hydroxypropyl group is quoted on the chitosan molecule, which changes the intermolecular space structure and weakens the hydrogen bond between chitosan molecules and intramolecules, thereby improving and enhancing its water solubility and reactivity. And hydroxypropylated chitosan has good water solubility, antibacterial and adsorption properties. The Chinese name of hydroxypropyl chitosan is hydroxypropyl chitosan, and the English name is Chitosan, N-(2-hydroxypropyl). Chitosan oligosaccharide, also known a...

AI Technical Summary

Problems solved by technology

At the same time, most of the wound plasters in the current stage are adhesive plasters, which are not tightly attached to the wound and have no effect on concave wounds. Moreover, the effective treatment of wounds by adhesive plasters is superficial and limited in scope. , limited by the shape and area of ​​the wound, the wound healing speed is slow. For the deep and dehiscated wound caused by the skin being scratched, the adhesive plaster type wound does not work at all for this wound. For the wound that hurts the dermis, the adhesive plaster type Band-aids are less effective in inhibiting scars. With the appearance of human body movements near the wound, the gap between the adhesive tape and the wound will be weak or not tight, and the scar inhibition and film-forming toughness is not enough or the film-forming property is poor. Although the latest technology has the antibacterial effect of chitosan Film-forming sprays or traditional Chinese medicine liquid bandages with active ingredients of chitosan, but the film-forming effect of chitosan alone is not enough. After film-forming, the mechanical properties are not strong, the viscosity is not enough, and it is easy to have raised scars and purple pigmentation present

Chitosan gel is applied to a large area of ​​wounds, which can easily lead to film formation and peeling, and the mechanical properties are not enough. The adhesive tape type wound will stick to the wound, and there will be pain when it is removed

And it is inconvenient to use, and it is easy to be limited by the position, size and shape of the wound

[0005] Existing liquid wound dressings are not viscous enough. For wounds that are scratched and cut open, they cannot play the role of skin-to-skin adhesion and cause the wound to crack. Although there is also a film covering, the toughness and viscosity are not enough. If the toughness is not enough, it is easy to be scratched off by clothing or other parts of the wound, resulting in a decline in the effect and slow healing speed, which will leave opportunities for abnormal proliferation of wound tissue

Secondly, there are few main components that inhibit the abnormal proliferation of wound tissue in the existing liquid bandages, which is also the reason for the abnormal proliferation of wound tissue.

Although the latest technology has antibacterial film-forming sprays of chitosan or traditional Chinese medicine liquid bandages with active ingredients of chitosan, it is not enough to rely solely on the film-forming effect of chitosan. After film formation, the mechanical properties are not strong and the viscosity is not enough.

Chitosan gel has little effect on inhibiting raised scars and eliminating purple pigmentation caused by wound tissue infection (it may take a long time if the purple pigment subsides naturally, or even permanently), chitosan gel If it is applied on a large area of ​​wounds, it will easily lead to film formation and skinning, and the mechanical properties are not enough. The adhesive plaster type wound will stick to the wound, and there will be pain when it is removed.

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