4-carboxyphenyl-beta-d-allosupranoside and application thereof to preparation of chronic neuropathic pain-resisting drug

A technology of allopyranoside and carboxybenzene, which is applied in the field of tofu fruit glycoside analogs, and can solve the problems of strong drug dependence, large dosage, and obvious side effects of drugs

Inactive Publication Date: 2016-05-04
KUNMING BAKER NORTON PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are still many problems in the relevant clinical medication: unsatisfactory curative effect, large dosage, obvious toxic and side effects of drugs, and strong drug toleranc...

Method used

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  • 4-carboxyphenyl-beta-d-allosupranoside and application thereof to preparation of chronic neuropathic pain-resisting drug
  • 4-carboxyphenyl-beta-d-allosupranoside and application thereof to preparation of chronic neuropathic pain-resisting drug
  • 4-carboxyphenyl-beta-d-allosupranoside and application thereof to preparation of chronic neuropathic pain-resisting drug

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Embodiment Construction

[0030] 1. Test article

[0031] Name: 4-Carboxyphenyl-β-D-alopyranoside (Code: H2)

[0032] Appearance: All are white or near white powdery crystals.

[0033] Source: The tested products were all synthesized by the inventor himself with tofu fruit glycoside as the starting material.

[0034] Drug preparation, administration solvent and administration route: before use, add distilled water for preparation, heat in a water bath to promote dissolution, and insoluble matter to make a suspension, stir well before use, and gavage with an administration volume of 10ml / kg.

[0035] 2. Comparative drugs

[0036] Gabapentin was purchased from Jiangsu Enhua Pharmaceutical Co., Ltd.; tofu glucoside was purchased from Kunming Pharmaceutical Group Co., Ltd. Before use, dissolve it in distilled water, and give it to the stomach at a dosage of 10ml / kg.

[0037] 3. Experimental animals

[0038] SD rats, normal grade, male, 220-240 g, were purchased from the Experimental Animal Center of K...

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Abstract

The invention discloses 4-carboxyphenyl-beta-D-allosupranoside and application thereof to preparation of a chronic neuropathic pain-resisting drug. The structural formula of the chronic neuropathic pain-resisting drug is shown in the specification. Experiments on a rat CCI model and a mouse PSNL model indicate that the compound has the effect of increasing pain threshold of feet and can be used for preparation of drugs for resisting chronic pain, especially chronic neuropathic pain.

Description

technical field [0001] The present invention relates to a tofu glucoside analogue, specifically 4-carboxyphenyl-β-D-alopyranoside and pharmaceutically acceptable salts, esters and solvates thereof, which are used for the preparation of therapeutic and / or prophylactic Use in medicine for chronic pain, for example for the treatment and / or prevention of neuropathic pain. Background technique [0002] According to the duration of pain, clinically, pain can be divided into two types: acute pain and chronic pain. The mechanisms of these two types of pain are essentially different. Acute pain is called nociceptive pain, that is, pain caused by tissue trauma. With the repair of tissue trauma, the pain stops naturally. Analgesics (such as narcotic analgesics and non-steroidal antipyretic analgesics) can be used during the attack period Chronic pain is mainly neuropathic pain, its pathogenesis is extremely complex, and it is difficult to treat, which is a new field of clinical resear...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/00A61K31/7034A61P25/00
CPCC07H15/203C07H1/00
Inventor 韩武建康洪钧段玲燕阳彦
Owner KUNMING BAKER NORTON PHARMA
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