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Transplant site-forming agent, transplant site-forming device, angiogenic agent and angiogenic device

An angiogenesis and inducer technology, applied in cyclic peptide components, tissue regeneration, medical preparations containing active ingredients, etc., can solve the problems of low tissue survival rate, lack of oxygen and nutrient supply, etc.

Inactive Publication Date: 2016-05-11
KYOTO UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] When tissues such as islets of pancreas are transplanted subcutaneously, there is a problem that the survival rate of the transplanted tissue is low because the development of small-diameter blood vessels in the subcutaneous tissue is insufficient, so the ability to supply oxygen and nutrients is insufficient.

Method used

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  • Transplant site-forming agent, transplant site-forming device, angiogenic agent and angiogenic device
  • Transplant site-forming agent, transplant site-forming device, angiogenic agent and angiogenic device
  • Transplant site-forming agent, transplant site-forming device, angiogenic agent and angiogenic device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145]

[0146] ACI rats (8-week-old male) were intraperitoneally administered streptozotocin (STZ) to produce diabetic rats. The blood glucose level was measured, and when it exceeded 400 mg / dL for 2 consecutive days, it was judged that diabetes was induced. 100 µg of SEK-1005 dissolved in alcohol was impregnated into a rod-shaped substrate made of 4.5% agarose gel with a length of 25 mm and a diameter of 4 mm. After fully volatilizing the alcohol, it was infiltrated with physiological saline. The spine of the diabetic rat was clamped, and the agarose rod was buried under the skin at two places on the left and right. As a control, agarose rods impregnated with physiological saline not containing SEK-1005 were buried subcutaneously at two places on the right and left, respectively, by clamping the spine of diabetic rats.

[0147] After 10 days, the agarose rods were taken out, and the surrounding tissues were observed. The results are shown in figure 1 . like figure 1 ...

Embodiment 2

[0150]

[0151] The above-mentioned diabetic ACI rats were used as recipients, and the F344 rats were used as donors, and islets were isolated, and changes in blood sugar levels after islet transplantation were examined. Specifically, the recipient's spine was clamped, and an agarose rod containing SEK-1005 produced by the same method as above was embedded subcutaneously in two places on the left and right, and the agarose rod was taken out 10 days later. 1500 (total 3000) islets isolated from F344 rats were transplanted respectively. As a control, the recipient's spine was clamped, and agarose rods not containing SEK-1005 were embedded subcutaneously in two places on the left and right. After 10 days, the agarose rods were taken out, and 1500 rods (a total of 3000 rods in total) were transplanted in the space after removal. ) Islets isolated from F344 rats.

[0152] The blood sugar level of recipients after transplantation of islets after taking out the agarose rod contain...

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Abstract

The invention provides a transplant site-forming agent that comprises SEK-1005, a transplant site-forming device, an angiogenic agent and an angiogenic device, and provides a transplant site-forming agent and a transplant site-forming device that exhibit an excellent engraftment rate of a transplant material, an angiogenic agent and an angiogenic device that exhibit an excellent ability of inducing angiogenesis, and an angiogenic agent and an angiogenic device that exhibit an excellent ability of inducing angiogenesis that is suitable for formation of a transplant material and the like.

Description

technical field [0001] The present invention relates to a transplantation site forming agent, a transplantation site forming device, an angiogenesis-inducing agent, an angiogenesis-inducing device, and an angiogenesis-inducing agent for inducing angiogenesis, an angiogenesis-inducing device suitable for obtaining the effect of: Formation of transplantation sites; transplantation of transplantation materials; promotion of survival of transplantation materials at transplantation sites; treatment of diabetes; control of blood sugar levels; and control of plasma insulin concentrations. [0002] In addition, the present invention relates to the use of the graft site forming agent or graft site forming device of the present invention in forming a graft site; use in inducing angiogenesis; use in transplanting a graft material; use in the survival of diabetes; use in the treatment of diabetes; use in the control of blood glucose levels; and use in the control of plasma insulin concent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/36A61F2/02
CPCA61F2/022A61L27/3604A61L27/54A61L2300/25A61L2430/40A61K35/12A61K35/39A61K35/407A61K38/12A61P41/00
Inventor 岩田博夫桒原令平野邦生
Owner KYOTO UNIV