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A method for reducing air bubbles in medical sodium hyaluronate gel

A technology of sodium hyaluronate and gel, which is applied to the types of packaging items, special packaging items, packaging, etc., and can solve problems such as increasing production costs, reducing product yield, and multiple bubbles

Active Publication Date: 2018-02-02
ZHEJIANG JINGJIA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, if the operation method is improper, the filtered medical sodium hyaluronate gel will produce more air bubbles, thereby reducing the product yield and increasing the production cost.

Method used

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  • A method for reducing air bubbles in medical sodium hyaluronate gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Comparative process: Vacuumize the gel in the batching tank at -0.1MPa for 30 minutes. Specification: 10mg / ml, 5ml / bottle. Lay the filter flat and pressurize the batching tank. When gel appears continuously in the exhaust valve of the filter, keep the pressure at 0.08-0.22MPa. After draining 100ml, check the filling capacity by weighing method and then fill 300 branch.

[0018] The present invention: vacuumize the gel in the batching tank at -0.1MPa for 30 minutes. Specification: 10mg / ml, 5ml / bottle. Put the outlet of the clarity filter upwards and place it vertically, then slightly open the bottom valve of the batching tank. When gel appears continuously from the exhaust valve of the clarity filter, close the exhaust valve to keep the pressure at 0.08-0.22MPa, drain 100ml, check the filling capacity by weighing method, and then fill 300 tubes.

Embodiment 2

[0020] Comparative process: Vacuumize the gel in the batching tank at -0.1MPa for 30 minutes. Specification: 13mg / ml, 5ml / bottle. Place the filter at an inclination of 45 degrees, pressurize the batching tank, and keep the pressure at 0.08-0.22MPa when the gel continuously appears in the exhaust valve of the filter. After draining 100ml, check the filling capacity by weighing method before filling Pack 300 pieces.

[0021] The present invention: vacuumize the gel in the batching tank at -0.1MPa for 30 minutes. Specification: 13mg / ml, 5ml / bottle. Put the outlet of the clarity filter upwards and place it vertically, then slightly open the bottom valve of the batching tank. When gel appears continuously from the exhaust valve of the clarity filter, close the exhaust valve to keep the pressure at 0.08-0.22MPa, drain 100ml, check the filling capacity by weighing method, and then fill 300 tubes.

Embodiment 3

[0023] Comparative process: Vacuumize the gel in the batching tank at -0.1MPa for 30 minutes. Specification: 15mg / ml, 5ml / bottle. Place the filter vertically with the liquid outlet facing down, and pressurize the batching tank. When gel appears continuously at the filter exhaust valve, keep the pressure at 0.08-0.22MPa. After draining 100ml, weigh it Fill 300 pieces after checking the filling volume.

[0024] The present invention: vacuumize the gel in the batching tank at -0.1MPa for 30 minutes. Specification: 15mg / ml, 5ml / bottle. Put the outlet of the clarity filter upwards and place it vertically, then slightly open the bottom valve of the batching tank. When gel appears continuously from the exhaust valve of the clarity filter, close the exhaust valve to keep the pressure at 0.08-0.22MPa, drain 100ml, check the filling capacity by weighing method, and then fill 300 tubes.

[0025] The final results after implementation are shown in Table 1.

[0026]

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PUM

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Abstract

The invention relates to a method for reducing medical sodium hyaluronate gel bubbles. The method sequentially includes the steps that firstly, vacuum pumping is conducted on gel in a burdening tank for 20-50 min, the vacuum degree is not lower than -0.085 MPa, and no bubble should exist in the gel in the tank according to observation; secondly, air is supplied to the burdening tank till the pressure intensity is 0.05-0.1 MPa; thirdly, the liquid outlet end of a clarity filter is made to face upwards, and the clarity filter is perpendicularly arranged; fourthly, an exhaust valve of the clarity filter is opened, and a bottom valve of the burdening tank is slightly opened; fifthly, when the gel continuously appears in the exhaust valve of the clarity filter, the exhaust valve is closed immediately; sixthly, pressure in the burdening tank is increased and kept in the range of 0.08-0.22 MPa; seventhly, downstream air of the clarity filter is exhausted through a filling pump, 50-100 ml of air is further exhausted when the gel appears, and part of condensate water is generated due to sterilization in a silicone tube and the filter; and eighthly, after checking and loading are conducted through a weighing method, filling can be conducted one by one. By means of the method for reducing the medical sodium hyaluronate gel bubbles, products obtained after filling are uniform in loading, basically no bubble exists in a needle tube, the filling yield is obviously increased, and the purposes of increasing the yield and quality are achieved.

Description

technical field [0001] The invention relates to the technical field of preparation of medical sodium hyaluronate gel, in particular to a method for reducing bubbles of medical sodium hyaluronate gel. Background technique [0002] During the filling process of medical sodium hyaluronate gel, a certain amount of gel is poured into the glass needle tube according to the predetermined amount. Because there are many types of gels with different performances, in order to increase the clarity of the gel after filling, medical sodium hyaluronate gels are often filtered with folded filter elements. Like this, if operation method is improper, the medical sodium hyaluronate gel after filtering will produce more air bubbles, thereby reduces product yield, increases production cost. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide an easy-to-operate method for reducing air bubbles in medical sodium hyaluronate gel in view of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08B65B3/22
CPCB65B3/22
Inventor 罗丽李建勇高陈
Owner ZHEJIANG JINGJIA MEDICAL TECH CO LTD