IDH1-R132H and ATRX expression based glioma prognostic system

A technology for IDH1-R132H and glioma, applied in the direction of material inspection products, measuring devices, instruments, etc., can solve the problem that it is difficult to clearly and objectively diagnose the pathological type of glioma, the prognosis of patients cannot be accurately judged, and the tumor biology cannot be fully reflected behavioral issues

Inactive Publication Date: 2016-05-25
江涛 +2
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Problems solved by technology

At present, the diagnosis of glioma is only based on morphology. It is difficult to clearly and objectively diagnose the pathological type of glioma, nor can it fully reflect the biological behavior of the tumor. It cannot accurately judge the prognosis of patients and guide postoperative clinical treatment.

Method used

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  • IDH1-R132H and ATRX expression based glioma prognostic system
  • IDH1-R132H and ATRX expression based glioma prognostic system
  • IDH1-R132H and ATRX expression based glioma prognostic system

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Embodiment Construction

[0019] The present invention will be described in further detail below in conjunction with embodiment.

[0020] 1. Patient information and source of specimens

[0021] A total of 211 cases of glioma were enrolled in this study, all from the Glioma Treatment Center of Beijing Tiantan Hospital. All patients received surgical resection, radiotherapy and alkylating agent treatment from January 2008 to March 2015, and the postoperative pathological diagnosis was glioma (according to the 2007 WHO classification criteria for tumors of the central nervous system).

[0022] Among all patients, there were 112 males and 99 females, aged 16-69 years, with an average (40) years old. The study was approved by the Ethics Committee of the relevant unit and the patients signed the informed consent.

[0023] 2. Paraffin embedding of tumor tissue

[0024] 2.1 Main instruments and reagents

[0025] Paraffin embedding machine: manufacturer: Hao Silin; product number: TEC2800

[0026] Milli-Q ...

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Abstract

The invention relates to an IDH1-R132H and ATRX expression based glioma prognostic system which comprises (1), a tumor paraffin-embedding kit for glioma patients and an operating instruction thereof if necessary; (2), a kit for immunohistochemically testing ATRX protein expression level of tumor of glioma patients and an operating instruction thereof if necessary; and (3), a kit for immunohistochemically testing IDH1-R132H protein expression of tumor of glioma patients and an operating instruction thereof if necessary. Progression free survival (PFS) of WHO II-level and III-level of glioma is typed according to loss states of IDH1-R132H and ATRX; patients with both loss of IDH1-R132H and ATRX has longer PFS than patients with both expression of IDH1-R132H and ATRX, and PFS of patients with IDH-WT is close to PFS of patients with glioblastoma.

Description

technical field [0001] The invention relates to the field of disease prognosis, in particular to a glioma prognosis system based on IDH1-R132H and ATRX. Background technique [0002] According to the WHO classification, diffuse gliomas are divided into grade II, grade III, and astrocytic glioma of glioblastoma, oligoastroglioma, and oligodendroglioma. Patients with lower-grade gliomas (LGGs, grade II) have a more favorable prognosis than patients with high-grade gliomas (grades III and IV), and in 50-75% of patients with low-grade gliomas, tumor Continues to grow and develop into higher levels, leading to neurological disease and eventual death. [0003] Astrocytoma is the most common pathological type of brain tumor, which is very prone to recurrence or malignant progression, and is difficult to cure even after surgery, radiotherapy and chemotherapy. Malignant astrocytomas such as glioblastoma are the deadliest intracranial tumors. The prognosis of patients with astrocyt...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574G01N33/573
CPCG01N33/6839G01N33/573G01N33/57484
Inventor 江涛蒋传路蔡金全
Owner 江涛
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