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Inflammation diminishing and whitening toothpaste containing rhizoma coptidis and fresh ginger

A technology of whitening and toothpaste, applied in the field of oral cleaning care, can solve problems such as easy inactivation, unstable dextranase, and difficulty in maintaining activity, so as to protect oral tissues, relieve tooth sensitivity pain, and solve gingival swelling and pain Effect

Inactive Publication Date: 2016-06-15
郭月华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Patent 98111713.9 announces that 98111713.9 discloses a kind of oral cleaning agent composition containing glucanase, which is used to treat periodontal tissue damage and inflammation such as dental caries and periodontitis, but dextranase is unstable and easily inactivated, so it is difficult to Difficult to maintain its activity in toothpaste

Method used

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  • Inflammation diminishing and whitening toothpaste containing rhizoma coptidis and fresh ginger

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0053] Experimental example 1, toothpaste stability investigation

[0054] According to the national standard GB8372-2008, put the anti-inflammatory and whitening toothpaste described in Examples 1-7 in a -8°C refrigerator, take it out after 8 hours, then put it in a 45±1°C constant temperature incubator for 8 hours, take it out, and place it at room temperature 4h, check the paste to investigate its stability. The results are shown in Table 2.

[0055] Table 2, Toothpaste Stability Test Investigation Results

[0056]

[0057] The results in Table 2 show that the anti-inflammatory and whitening toothpaste described in Examples 1-7 has normal color and fragrance, no flatulence, consistency change and water splitting, and the pH value is also within the normal range.

experiment example 2

[0058] Experimental example 2. Effect on pain caused by hot plate

[0059] Test product: Anti-inflammatory whitening toothpaste aqueous solution (1g / ml) Experimental materials: Cranidinidine and normal saline were purchased from Guangdong Medical College. Animals: Kunming mice, normal grade, weighing 18-22 g; guinea pigs, normal grade, weighing 180-220 g, provided by the Animal Center of Guangdong Medical College. 40 pre-selected healthy male and female KM mice (those with pain threshold within 30s), weighing 18-22g, were randomly divided into 4 groups. The grouping, dosage and method of administration were the same as the previous analgesic experiment. After administration, the pain threshold of each group was measured by hot plate method at 60', 90', and 120', and the results are shown in Table 3.

[0060] Table 3 Effect of anti-inflammatory and whitening toothpaste aqueous solution on hot plate pain threshold of mice (X±S, S)

[0061] group Dose (g / kg) Numb...

experiment example 3

[0063] Experimental example 3. Observation of the anti-inflammatory effect of anti-inflammatory and whitening toothpaste

[0064] Set up two groups, one is the experimental group and the other is the control group.

[0065] Experimental group 1 is the anti-inflammatory and whitening toothpaste prepared in Example 1 of the present invention;

[0066] Experimental group 2 is the anti-inflammatory and whitening toothpaste prepared in Example 7 of the present invention;

[0067] Control group 1: Anti-inflammatory and whitening traditional Chinese medicine toothpaste without coptis and ginger, prepared according to the formula and preparation method of Example 1 of the present invention;

[0068] Control group 2: general anti-inflammatory toothpaste in the market;

[0069] Choose 10 volunteers each for toothache, gingivitis, oral ulcer and halitosis for comparison test. Select 5 volunteers, respectively use the toothpaste of each test group for 3 days, once a day in the morning ...

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Abstract

The invention provides inflammation diminishing and whitening toothpaste containing rhizoma coptidis and fresh ginger.The inflammation diminishing and whitening toothpaste contains effective ingredients, namely, rhizoma coptidis and fresh ginger and auxiliary ingredients, namely, menthol, borneol and pearl powder.The inflammation diminishing and whitening toothpaste is quite stable in the expected packaging, storage and transportation, sale and use processes.When the inflammation diminishing and whitening toothpaste is frequently used for tooth brushing, a good treatment effect can be achieved for dental ulcers, a protection effect is achieved for allergic gingivae, and meanwhile teeth can be whitened.

Description

technical field [0001] The invention relates to the field of oral cleaning care, in particular to an anti-inflammatory and whitening toothpaste containing coptis and ginger. Background technique [0002] In recent years, many types of toothpastes have appeared on the market. With the accelerated pace of modern life, various types of toothpastes have also appeared one after another, such as anti-inflammatory toothpaste, whitening toothpaste, and anti-allergic toothpaste. Yes, some add pure chemical synthetic ingredients, some add natural extract ingredients, and some add developed combination ingredients, but in my country, inheriting the concept of traditional Chinese medicine, Chinese herbal toothpaste should be more popular with domestic consumers, but Chinese herbal toothpaste usually contains biological Alkali and strong irritating substances, and the toothpaste on the market has a single function, which is not suitable for long-term use. It may damage the oral mucosa, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/97A61K8/73A61K8/46A61K8/34A61K8/29A61K8/25A61Q11/00A61P1/02A61K8/9789A61K8/9794
CPCA61K8/97A61K8/25A61K8/29A61K8/34A61K8/345A61K8/463A61K8/73A61K8/731A61K8/987A61K31/045A61K35/618A61K36/185A61K36/718A61K36/9068A61K2800/28A61K2800/412A61Q11/00A61K2300/00
Inventor 梁修剑
Owner 郭月华
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