Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs

A technology for eupholzanthin and pulmonary fibrosis, which is applied in the field of natural chemical substances, can solve problems such as the application of eupholzanthin that have not been reported yet, and achieve the effect of wide practical value and clear pharmacological activity

Inactive Publication Date: 2016-06-15
CHINA PHARM UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0007] At present, there is no report on the effect of eupholzanthin on improving pu

Method used

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  • Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs
  • Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs
  • Application of Eupatilin in preparation of pulmonary fibrosis resistant drugs

Examples

Experimental program
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Embodiment 1

[0043] 1. Preparation and structure confirmation of eupholzanthin

[0044] Artemisia argyi Levl. et Vamt. is the dried leaf of Artemisia argyi Levl. et Vamt., purchased from Anguo, Hebei. Dry Artemisia argyi 10kg, heat and reflux extract 3 times with 70% ethanol solution by volume fraction, combine, recover the solvent under reduced pressure, concentrate the obtained aqueous solution and extract with petroleum ether, chloroform, ethyl acetate, n-butanol respectively. 100.0 g of the chloroform extraction layer was eluted through silica gel column chromatography with chloroform-methanol (100:0-0:100) as the mobile phase to obtain 5 fractions A-E, and fraction B was eluted through silica gel column chromatography with chloroform-methanol (100:0-0- 2:1) was used as the mobile phase for elution to obtain 3 fractions a, b, and c. Fraction a was prepared by recrystallization to obtain eupholzanthin. The physical and chemical properties and spectral data are as follows: yellow powde...

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Abstract

The invention relates to application of a chemical substance Eupatilin for treating pulmonary fibrosis. The compound Eupatilin is obtained from traditional Chinese medicine Folium Artemisiae Argyi, the structure of the Eupatilin is determined according to spectrum data, the fibrosis degree of lung tissues of model mice is improved obviously after intragastric administration of the Eupatilin, NO content and MDA content which reflect lung damage degree are reduced, HYP content reflecting lung tissue collagen deposition is lowered, and the content of cell factor TGF-beta 1 causing the pulmonary fibrosis is decreased; human embryonic lung fibroblast proliferation and HYP content are inhibited in vitro. In-vivo and in-vitro experiments show that the Eupatilin can remarkably improve bleomycin induced pulmonary fibrosis of the mice, and can be applied to drugs for treating the pulmonary fibrosis.

Description

technical field [0001] The invention relates to a new application of a natural chemical substance eupholzanthin as a drug for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis (PF) is a chronic interstitial lung disease with insidious onset, rapid progression, high mortality and poor treatment effect. Deposition in the pulmonary interstitium is characteristic. Pulmonary fibrosis is caused by various pathogenic factors inside and outside the lungs, and is the result of a series of chronic lung injuries or the development of advanced diseases, which seriously endangers human health. [1] . [0003] The pathogenesis of pulmonary fibrosis has not yet been fully clarified. The research theory generally involves these four aspects, including inflammatory cell imbalance, cytokine secretion and response imbalance, signal transduction mechanism, and lipid peroxidation. A process in which multiple factors and multiple links participate in each other. Its...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00A61K36/282
CPCA61K31/352A61K36/282
Inventor 张朝凤陶丽君曹娟
Owner CHINA PHARM UNIV
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