Moisturizing patches comprising silica-containing complex nanoparticle

A composite nanoparticle and silicon dioxide technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problem that it is difficult to maintain the hydration state for a long time, and achieve the effect of improving elasticity and improving state.

Inactive Publication Date: 2016-07-06
金周垣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the hydrogel patch prepared based on water-soluble polymers immediately hydrates the outer horn layer of the skin when it is attached to the skin, thereby imparting a moisturizing feeling, it is difficult to maintain it for a long time without additional system improvement Hydration state

Method used

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  • Moisturizing patches comprising silica-containing complex nanoparticle
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  • Moisturizing patches comprising silica-containing complex nanoparticle

Examples

Experimental program
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preparation example Construction

[0024] In the present invention, the composite nanoparticles can be prepared by the following preparation method, the preparation method includes: 1) the step of introducing amine groups to the surface of the silica particles by performing a coupling reaction between silica and a silane compound 2) A step of introducing trichloroacetyl groups to the surface of the silica particles by subjecting the silica particles obtained in the above step 1) to a condensation reaction with trichloroacetyl isocyanate; and 3) by making the above step 2) The obtained silica particles undergo a polymerization reaction with the polymer monomer in the presence of a crosslinking agent to introduce the zwitterionic polymer film layer onto the surface of the silica particles.

[0025] In the above method, step 1) is a step of introducing an amine group to the surface of the silica particles by performing a silica-silane coupling reaction in order to increase the reactivity.

[0026] Silica is converted i...

Embodiment

[0055] Hereinafter, the present invention will be described in more detail through examples. However, these Examples are only to illustrate the present invention, and the scope of the present invention is not limited to these.

preparation example

[0056] Preparation example: Synthesis of silica / zwitterionic polymer composite nanoparticles

[0057] In order to prepare silica / zwitterionic polymer composite nanoparticles composed of silica and zwitterionic polymer coated on the surface of the silica particles in the form of a film, the following preparation steps are performed.

[0058] Reagent

[0059] Silica (Ludox CL-X) purchased from Aldrich was used. The average particle size of the silica is 22 nm, the surface potential of the silica is negative, and sodium is used as a stabilizing counterion. The silica is in the form of being dispersed on water, and its concentration is 45% by weight.

[0060] 2-Methacryloxyethylphosphocholine (MPC), 3-aminopropyltriethoxysilane (APS), trichloroacetyl isocyanate, dibutyltin dilaurate and divinylbenzene (DVB) are all purchased From Sigma-Aldrich Company, dibutyltin dilaurate was used as the urethane reaction catalyst, and DVB was used as the crosslinking agent.

[0061] Step 1) Introduct...

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Abstract

The present invention relates to a moisturizing patch which consists of silica and a zwitterion high polymer thin film coated on the surface of the silica and contains complex nanoparticles, polysaccharides, and natural high polymer substances. The moisturizing patch of the present invention not only retains moisture for 120 hours with just one use on a user's skin but also helps improve skin health by giving moisture and improving elasticity when continually used for a long time.

Description

Technical field [0001] The present invention relates to a moisture patch including silica-containing composite nanoparticles ( ). Background technique [0002] Dust and heavy metals in the air can increase skin sebum secretion, acne and various allergies, and accelerate skin keratosis and desiccation. Therefore, the skin exposed to heavy metals becomes very sensitive, so special care such as anti-inflammatory and anti-allergic is required. In order to remove foreign matter such as floating dust and heavy metals on the skin, skin care such as washing is required. In order to perform the skin care, skin beauty sheets or patches can be used. [0003] Since the skin beauty sheet or patch contains a fibrous matrix, it can not only absorb substances such as heavy metals, and because it contains a beauty liquid, it can directly deliver effective ingredients, moisturizing ingredients, etc. to the skin. Among them, a moisture patch that can impart a sense of moisture and moisture to th...

Claims

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Application Information

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IPC IPC(8): A61K8/81A61K8/25A61K8/73A61K8/02A61Q19/00
CPCA61K8/0208A61K8/25A61K8/55A61K8/73A61K2800/413A61K2800/622A61Q19/00B82Y5/00
Inventor 金周垣
Owner 金周垣
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