Unlock instant, AI-driven research and patent intelligence for your innovation.
A kind of compound lidocaine pharmaceutical composition and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of lidocaine and composition, applied in the field of medicine, can solve problems affecting product quality, unsatisfactory stability, and decreased stability, and achieve the effects of shortening operation time, enhancing percutaneous penetration, and high stability
Active Publication Date: 2019-06-11
SHANXI YUANYANG PHARMA TECH
View PDF7 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0005] However, the microemulsion prepared by the traditional method has unsatisfactory stability to a certain extent, which usually shows as stratification, floc and precipitation after standing for a period of time, especially when the temperature is high, the stability At the same time, there are generally other additives such as chemical penetration enhancers, traditional preservatives and ion polymers in traditional microemulsions, which not only affect product quality, but also have large side effects and low safety
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0034] [Preparation method] Weigh the oil phase, surfactant, co-surfactant, lidocaine and prilocaine according to the formula and stir to form a mixed drug solution, then add dropwise the water weighed according to the formula, using The pharmaceutical composition is prepared by adding water dropwise.
Embodiment 2
[0036] [Recipe] Lidocaine 3g, prilocaine 2g, oleic acid 9g, Tween-80 13g, ethanol 9g and water 60g.
[0037] [Preparation method] Weigh the oil phase, surfactant, co-surfactant, lidocaine and prilocaine according to the formula and stir to form a mixed drug solution, then add dropwise the water weighed according to the formula, using The pharmaceutical composition is prepared by adding water dropwise.
Embodiment 3
[0039] [Recipe] Lidocaine 2.5g, prilocaine 2.5g, ethyl oleate 5.5g, polyoxyethylene castor oil 15.5g, polyethylene glycol 400 7.5g and water 70g.
[0040] [Preparation method] Weigh the oil phase, surfactant, co-surfactant, lidocaine and prilocaine according to the formula and stir to form a mixed drug solution, then add dropwise the water weighed according to the formula, using The pharmaceutical composition is prepared by adding water dropwise.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
Login to View More
Abstract
The invention provides a compound lidocaine medicine composition. The composition is prepared from lidocaine, prilocaine, an oil phase, a surfactant, a cosurfactant and water. According to the method, a hydrophilic drug prilocaine and a lipophilic drug lidocaine are introduced into a microemulsion system in a reasonable proportion. The system can be used for enhancing the transdermal permeation effect of the two drugs at the same time and greatly shortening the effect of local anaesthesia, can be applied to local cortex before injection to reduce patient pain and improve compliance, and can be applied to patients requiring operation as soon as possible to greatly reduce the waiting time of anaesthesia and shorten the operation time. Furthermore, the pharmaceutical composition has high stability, can be stored for 9 months at 25 DEG C and 40 DEG C, does not contain penetration enhancer, preservative, ionic polymer or other additives, and is simple in composition, high in quality, small in side effect and high in safety.
Description
technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a compound lidocaine pharmaceutical composition and a preparation method thereof. Background technique [0002] Compound lidocaine cream is a compound cream prepared from two local anesthetics, lidocaine and prilocaine. Abroad, it was first listed in the 1980s by the Swedish company Astra (trade name EMLA), and now it has been listed in more than a dozen countries including China and the United States. The drug is mainly aimed at the problem that existing anesthetics (including injections, latex and solutions) are difficult to penetrate the stratum corneum and epidermis of the intact skin, enter the dermis where the nerve endings that feel pain are located, and exert an analgesic effect. An effective topical anesthetic capable of penetrating intact skin. [0003] At present, the most widely used dosage form of compound lidocaine is emulsifiable paste or patch, suc...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
