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Nose spraying water and preparing method thereof

A nasal spray and coarse particle technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, medical raw materials derived from Mahuangmen, etc. Comfort of use, rapid onset of action, guaranteed hygienic quality

Inactive Publication Date: 2016-07-20
朱守信
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral drugs must be decomposed by the digestive tract, and then sent to the nasal mucosa through the systemic circulation. The amount of drug reaching the nose is very small, and the drug efficiency is low
However, topical drugs can only temporarily improve nasal ventilation, and the duration of the drug effect is short after a single dose, requiring multiple doses per day, which is inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A kind of nasal spray, the raw material component that adopts comprises:

[0045] 10 parts by weight of andrographis paniculata, 20 parts by weight of sarcocarpus, 0.2 parts by weight of borneol, 15 parts by weight of magnolia flower, 0.5 part by weight of ephedra, and 0.2 part by weight of toad venom.

[0046] The preparation method of above-mentioned nasal spray, comprises the following steps:

[0047] (1) Weigh andrographis paniculata, syringae, magnolia and ephedra according to the above parts by weight, and use the moist heat sterilization method to sterilize the above raw materials, the sterilization temperature is 121 ° C, and the sterilization time is 30 minutes;

[0048](2) Place the sterilized raw material components obtained in step (1) in a drying box respectively, and dry them for 6 hours at 70°C; then pulverize the above raw material components respectively, and sieve , obtaining Andrographis paniculata coarse granules, Sarcophyllum sarcocarpa coarse gran...

Embodiment 2

[0056] A kind of nasal spray, the raw material component that adopts comprises:

[0057] 40 parts by weight of andrographis paniculata, 60 parts by weight of sarcocarpus, 1 part by weight of borneol, 30 parts by weight of magnolia flower, 0.2 part by weight of ephedra, and 0.5 part by weight of toad.

[0058] The preparation method of above-mentioned nasal spray, comprises the following steps:

[0059] (1) Weigh andrographis paniculata, syringae, magnolia and ephedra according to the above parts by weight, and use the moist heat sterilization method to sterilize the above raw materials, the sterilization temperature is 121 ° C, and the sterilization time is 30 minutes;

[0060] (2) Place the sterilized raw material components obtained in step (1) respectively in a drying box, and dry them for 8 hours at 75°C; then pulverize the above raw material components respectively, and sieve , obtaining Andrographis paniculata coarse granules, Sarcophyllum sarcocarpa coarse granules, Ma...

Embodiment 3

[0068] A kind of nasal spray, the raw material component that adopts comprises:

[0069] 60 parts by weight of andrographis paniculata, 30 parts by weight of sarcocarpus, 2 parts by weight of borneol, 20 parts by weight of magnolia flower, 1.2 parts by weight of ephedra, and 0.9 parts by weight of toad.

[0070] The preparation method of above-mentioned nasal spray, comprises the following steps:

[0071] (1) Weigh andrographis paniculata, syringae, magnolia and ephedra according to the above parts by weight, and use the moist heat sterilization method to sterilize the above raw materials, the sterilization temperature is 121 ° C, and the sterilization time is 30 minutes;

[0072] (2) Place the sterilized raw material components obtained in step (1) in a drying box respectively, and dry them for 7 hours at 80° C.; then pulverize the above raw material components respectively, and sieve , obtaining Andrographis paniculata coarse granules, Sarcophyllum sarcocarpa coarse granule...

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Abstract

The invention relates to nose spraying water.The nose spraying water comprises, by weight, 10-60 parts of common andrographis herbs, 10-60 parts of glabrous sarcandra herbs, 0.2-3 parts of borneol, 5-30 parts of flos magnoliae liliflorae, 0.2-1.2 parts of ephedra herbs and 0.2-0.9 part of venenum bufonis.The invention further relates to a preparing method of the nose spraying water.The preparing method includes the steps that the active ingredients in the common andrographis herbs and the active ingredients in the glabrous sarcandra herbs are extracted with the supercritical fluid extraction method, the active ingredients in ephedra herbs are extracted with the ethanol reflux extract method, the active ingredients in the flos magnoliae liliflorae are extracted with the steam distillation method, the borneol and the venenum bufonis are smashed, absolute ethyl alcohol and distilled water are added, the mixture is mixed to be even and subjected to split charging, and the nose spraying water is obtained.The nose spraying water is simple in formula, rapid in effect taking and safe in use, discharging of purulent secretion in the nose cavity can be effectively promoted, the medicine effect of single medicine using can be continuously kept for 12 hours or above, and the curing rate is high.The preparing method of the nose spraying water is high in extracting efficiency, free of residual organic solvents in the extracting process and suitable for mass production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to a nasal spray and a preparation method thereof. Background technique [0002] In recent years, with the increasing air pollution, the number of various pathogenic microorganisms and allergens in the air has increased, and the incidence of various nasal inflammations has gradually increased. [0003] Nasal inflammation refers to the inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases, including multiple types, such as chronic simple rhinitis, chronic hypertrophic rhinitis, atrophic rhinitis, etc. . Inflammation of the nasal cavity will not only bring symptoms such as nasal congestion, runny nose, headache, and hyposmia, but also cause various complications. Simultaneously, nasal cavity inflammation recurs easily, is difficult for curing, has a strong impact on patient's normal wor...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61P11/02A61K31/045A61K35/65
CPCA61K36/575A61K31/045A61K35/65A61K36/17A61K36/185A61K36/19A61K2236/33A61K2236/331A61K2236/37A61K2300/00
Inventor 朱守信
Owner 朱守信
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