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Preterm milk formula

一种配方、早产儿的技术，应用在营养补充剂领域，能够解决没有考虑早产儿卡路里和蛋白质的需求等问题

Inactive Publication Date: 2016-09-21
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, formulations for providing the required nutrients to premature infants and methods of their use still do not take into account the desired and required caloric and protein requirements of premature infants, especially not in an easy and cost-effective manner.

Method used

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  • Preterm milk formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1: Formula Supplement for Premature Infants - Protein Booster

[0106] Provide protein booster including 20g protein / 100ml; 80kcal protein / 100ml. The composition comprises about 85% protein based on dry weight of the composition and about 90% protein based on total calories. The protein composition comprises about 0.12 g / ml hydrolyzed whey protein (eg from Arla or Fonterra) and about 0.08 g / ml hydrolyzed casein (eg from DMV or Fonterra). Due to the commercial products used, in addition to protein, small amounts (<10%) of minerals, vitamins, lactose and fat were present.

[0107] The protein is packaged in ampoules in a volume of 1 ml. The protein composition is sterilized.

Embodiment 2

[0108] Example 2: Preterm Formula Administered Proteins Reconstituted Using Variable Amounts of Preterm Formula Supplements

[0109] A standard commercially available preterm formula (Aptamil, Prematil) (comprising 3.1 g protein / 100 kcal, 2.5 g protein / 100 ml; and 80 kcal / 100 ml) was used.

[0110] Supplementation of this formula with 4ml, 3ml and 2ml / 100ml of the preterm formula supplement of Example 1 resulted in the addition of 0.8, 0.6 and 0.4g of protein to 100ml respectively, resulting in 104, 103 and 102ml supplemented formula respectively.

[0111] Administering the recommended daily intake of calories, the protein intakes of LBW, VLBW and ELBW infants were calculated when administered the range of (fortified) preterm formulas based on body weight, and compared to when administered a prior art preterm formula protein intake compared. The results are compared with the theoretical recommended daily intake and shown in the table.

[0112] Table: Protein intake of LBW, V...

Embodiment 3

[0120] Example 3: Protein Supplement (Fortifier) ​​for Supplementing Human Milk or Standard HMF Fortified Human Milk

[0121] Harvested expressed human milk was fortified with standard HMF.

[0122] Standard HMF is a powder composition in a sachet containing 2.2 g. It comprises 25.2 g of protein per 100 g of powder (1 / 1 weight ratio of whey and casein), and 62.2 g of digestible sugars, the remainder being minerals, especially calcium and phosphate, trace elements and vitamins. The protein content is 29% based on total calories. HMF was added to human milk in an amount of 4.4g / 100ml. This standard HMF-fortified human milk was then supplemented with 2ml or 1ml / 100ml of the preterm formula supplement of Example 1, resulting in the addition of 0.4 and 0.2g of protein to 100ml respectively, resulting in 102 and 101ml supplemented formula, respectively.

[0123] HMF-fortified human milk given to preterm infants weighing 1800 to 2500.

[0124] Infants weighing 1000 to 1800 g were...

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Abstract

The invention provides a preterm milk formula. The present invention relates to a protein fortifier for use in varying the amount of protein in preterm infant nutrition, thereby adapting the formula or human milk to the nutritional needs of very low birth weight infants and extremely low birth weight infants.

Description

[0001] This application is a divisional application of the application dated May 18, 2011, the application number is 201180024405.3, and the invention name is "premature milk formula". technical field [0002] The present invention relates to nutritional supplements for premature infants. Background technique [0003] The number of surviving newborns with low birth weight has increased significantly over the past two decades. About 16% of newborn babies have low birth weight. The phenotype is due to preterm birth (ie, born before 37 weeks of gestation) and / or growth restriction in utero for small-for-gestational-age (SGA) infants. The primary goal of enteral nutrition provided to these infants is to achieve growth resembling fetal growth with satisfactory functional development. [0004] Many infant formulas for term infants are commercially available. However, these formulas are not optimal for administration to low birth weight infants, since the full nutritional requir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/20A23L33/19A23L33/00
CPCA23C9/20A23C9/206A23V2002/00A23V2200/08A23V2250/54246A23V2250/54252A23L33/40A23L33/19
Inventor 吉尔达·埃莉斯·乔治B·斯塔尔
Owner NV NUTRICIA
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