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External-use medicine prepared from optically active material composition and used for treating haemorrhoids and preparation technology of external-use medicine

A raw material composition and optically active technology, applied in the field of medicine, can solve the problems of low bioavailability, slow treatment of hemorrhoids, complicated preparation methods, etc., achieve improved therapeutic effect, meet quality analysis and control conditions, and achieve good therapeutic effect Effect

Active Publication Date: 2016-10-05
中微知著药物手性技术(大连)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of hemorrhoids is mainly to improve the blood circulation of the perianal and hemorrhoidal veins, and to eliminate the excessive varicose and filling of the veins. The main treatment method is surgery, but there are many complications during the operation, and the easy recurrence is the reason why many patients do not want to undergo surgery. , the effect is not very ideal; in the existing medicine for treating hemorrhoids, musk is used as a raw material, and the medicinal musk on the market is divided into two types, namely natural musk and artificial musk. The bioactive ingredients and aroma center in the muscone, its content is only 1.5% to 2.0%, although the racemic muscone is effective for hemorrhoids, the effect is not obvious
Chinese patent CN 102885893 A discloses a pharmaceutical composition for treating hemorrhoids. The traditional Chinese medicine composition is made from musk, borneol, verdigris, raw nuxychonna, and alum. Effective dosage, although this product can treat hemorrhoids, its bioavailability is not high, the treatment effect on hemorrhoids is slow, and it is easy to relapse; and there are many raw materials, whether its compatibility is suitable also needs to be verified, and the preparation method is complicated

Method used

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  • External-use medicine prepared from optically active material composition and used for treating haemorrhoids and preparation technology of external-use medicine
  • External-use medicine prepared from optically active material composition and used for treating haemorrhoids and preparation technology of external-use medicine
  • External-use medicine prepared from optically active material composition and used for treating haemorrhoids and preparation technology of external-use medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Composition of Example 1

[0058] prescription:

[0059] L-Muskone 30g Tianhetamic Acid 10g

[0060] Preparation:

[0061] Grinding the prescribed amount of astragalus into fine powder 1, mixing the prescribed amount of levothycone and ethanol at a ratio of 1:2 to obtain solution 1, mixing the fine powder 1 and solution 1 evenly, A composition is prepared.

Embodiment 2

[0062] Composition of Example 2

[0063] An optically active raw material composition, which is prepared by processing the following raw materials in parts by weight:

[0064] L-Muskone 200g Amino Acid 100g

[0065] Preparation method: prepare the composition according to the preparation method of Example 1.

Embodiment 3

[0066] Example 3 Composition

[0067] prescription:

[0068] Levothyroxone 115g Aminoline 55g

[0069] Preparation method: prepare the composition according to the preparation method of Example 1.

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Abstract

The invention discloses an optically active raw material composition, which is prepared by using the following raw materials: L-musketone and beta heptamic acid. The invention provides an optically active raw material composition which can effectively treat hemorrhoids, has good therapeutic effect, quick effect, no recurrence, no toxic and side effects, is difficult to recur after being cured, has high biological activity utilization, and is easy for the drug to be absorbed by human skin. The external preparation prepared by the composition has short treatment period for hemorrhoids, good treatment effect, quick effect, is difficult to relapse after being cured, has no toxic and side effects, has obvious anti-inflammatory, analgesic and hemostatic functions, and can obviously eliminate granulation swelling antihemorrhoid effect. The composition and the external preparation provided by the invention can effectively treat internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and have high recovery rate and effective rate in the treatment of hemorrhoids, with the recovery rate reaching 93.9% and the effective rate reaching 100%.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an external medicine for treating hemorrhoids with a prescription of an optically active raw material composition and a preparation process. technical background [0002] Anorectal hemorrhoidal fistula is a common and frequently-occurring disease unique to humans. Data show that the incidence rate of anorectal diseases is 59.1%, and hemorrhoids account for 87.25% of all anorectal diseases, and among them, internal hemorrhoids are the most common, accounting for 52.19% of all anorectal diseases; both men and women can get the disease, and the incidence rate of women It is 67%, and the male's incidence rate is 53.9%; Any age can fall ill, and wherein the people of 20-40 years old is comparatively common, and modern medicine comprises methods such as internal use of Chinese medicine, external use and Western medicine operation to the treatment of hemorrhoids. At present, the tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P9/14A61K31/122
Inventor 王倩影王狄
Owner 中微知著药物手性技术(大连)有限公司
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