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Composition having anti-fatigue effects and preparation method and use thereof

A composition and anti-fatigue technology, applied in the directions of medical preparations containing active ingredients, drug combinations, applications, etc.

Inactive Publication Date: 2016-10-26
SINPHAR TIAN LI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of western medicine, most of them combat fatigue by supplementing carbohydrates, proteins and other energy substances, removing metabolites, supplementing antioxidants, and using tonics. clubhouse disabled

Method used

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  • Composition having anti-fatigue effects and preparation method and use thereof
  • Composition having anti-fatigue effects and preparation method and use thereof
  • Composition having anti-fatigue effects and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Wash 25kg of dried rosebuds, add 30 times its mass in 70% ethanol solution, stir and extract at 60°C for 2 hours, extract three times, combine three extracts, concentrate to 50°C to a density of 1.04g / mL , just dry, and the yield is 18.1%.

[0035] Wash 100kg of dried poria cocos, crush it through a 24-mesh sieve, add its mass to 10 times the volume concentration of 75% ethanol solution, soak for 5 hours, reflux extraction for 4 hours, extract twice, combine the two extracts, concentrate to 50 ° C to The density is 1.05g / mL, dried under reduced pressure, and the yield is 0.42%.

[0036] Wash 16kg of dried jujube, slice it (5-7mm in thickness), mix it with purified water at a mass ratio of 1:30, stir and extract at 80°C for 100min, extract twice, combine the two extracts, and depressurize Concentrate to 55°C until the solid content is 0.18g / mL, the volume of the concentrated solution is 28.3L, the calculated solid content in the concentrated solution is 5.1kg, add the e...

Embodiment 2

[0038] Wash 25kg of dried rosebuds, add 30 times its mass in 70% ethanol solution, stir and extract at 80°C for 1 hour, extract three times, combine three extracts, concentrate to 60°C to a density of 1.02g / mL , dry it, and the yield is 19.6%.

[0039]Wash 100kg of dried poria cocos, crush through a 24-mesh sieve, add its mass to 8 times the volume concentration of 70% ethanol solution, soak for 5 hours, reflux for 3 hours, extract twice, combine the two extracts, concentrate to 55 ° C to The density is 1.07g / mL, dried under reduced pressure, and the yield is 0.40%.

[0040] Wash 16kg of dried jujube, slice it (5-7mm in thickness), mix it with purified water at a mass ratio of 1:30, stir and extract at 90°C for 100 minutes, extract twice, combine the two extracts, and depressurize Concentrate to 55°C until the solid content is 0.16g / mL, the volume of the concentrated solution is 31.2L, the calculated solid content in the concentrated solution is 5.0kg, add the extracts of ros...

Embodiment 3

[0041] Example 3: Evaluation of the effect of compositions on zebrafish locomotion

[0042] The anti-fatigue drug efficacy evaluation model of zebrafish is from the literature: Fan Nengquan, Peng Lan, Yang Wu, Zhang Pu, Jiang Jingzi. A preliminary study on the effect of rhodiola rosea on zebrafish swimming and hypoxia tolerance, "Journal of Pharmaceutical Analysis", 2015 , 8: 1342-1345. The entire contents of which are incorporated herein by reference.

[0043] The experimental animals were wild-type AB strains, and each experimental group consisted of 30 zebrafish, which were incubated in an incubator at 28°C. The normal control group is normal zebrafish treated with fish culture water; the zebrafish is induced with sodium sulfite as the zebrafish hypoxic fatigue model; the composition (batch number Z-1) with a concentration of 5, 17 and 50 μg / mL is taken for evaluation, The zebrafish in the model group were treated with water-soluble samples, and the Zhonghua Dieda Pill wa...

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Abstract

The present invention relates to a composition having anti-fatigue effects and a preparation method and a use thereof. The composition comprises a rose extract, a poria cocos extract and a red jujube extract. The preparation method comprises the following steps: solvent adding, soaking, extracting, concentrating and drying. The prepared composition has significant anti-fatigue effects and can be used for preparing medicines, food or health-care food for treating or preventing fatigue symptoms.

Description

technical field [0001] The invention belongs to the field of health products, and relates to a preparation method of a composition processed from natural plants, in particular to an anti-fatigue composition. The composition of the present invention can be used as food, health food, or medicine. Background technique [0002] Fatigue is the result of complex physiological and biochemical changes in the body. From the central nervous system to skeletal muscle cells to the metabolic process in cells, any link or process in the middle can cause fatigue. Fatigue not only reduces the original working ability of the body, but also prompts the body to develop a certain degree of injury. After the human body is in a state of fatigue, if it is not treated and eliminated in time, it will gradually accumulate, eventually leading to overwork and chronic fatigue syndrome. [0003] With the development of society and the accelerated pace of people's work and life, fatigue has become the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L31/00A23L19/00A61K36/738A61P39/00
CPCA61K36/738A23V2002/00A61K36/076A61K36/725A61K2236/331A61K2236/333A61K2236/51A23V2200/30A23V2250/208A23V2250/21A61K2300/00
Inventor 王昭日杨胜杰刘明川杨进平洪达张丽张小琴温新然
Owner SINPHAR TIAN LI PHARMA
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