Composition having anti-fatigue effects and preparation method and use thereof
A composition and anti-fatigue technology, applied in the directions of medical preparations containing active ingredients, drug combinations, applications, etc.
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Embodiment 1
[0034] Wash 25kg of dried rosebuds, add 30 times its mass in 70% ethanol solution, stir and extract at 60°C for 2 hours, extract three times, combine three extracts, concentrate to 50°C to a density of 1.04g / mL , just dry, and the yield is 18.1%.
[0035] Wash 100kg of dried poria cocos, crush it through a 24-mesh sieve, add its mass to 10 times the volume concentration of 75% ethanol solution, soak for 5 hours, reflux extraction for 4 hours, extract twice, combine the two extracts, concentrate to 50 ° C to The density is 1.05g / mL, dried under reduced pressure, and the yield is 0.42%.
[0036] Wash 16kg of dried jujube, slice it (5-7mm in thickness), mix it with purified water at a mass ratio of 1:30, stir and extract at 80°C for 100min, extract twice, combine the two extracts, and depressurize Concentrate to 55°C until the solid content is 0.18g / mL, the volume of the concentrated solution is 28.3L, the calculated solid content in the concentrated solution is 5.1kg, add the e...
Embodiment 2
[0038] Wash 25kg of dried rosebuds, add 30 times its mass in 70% ethanol solution, stir and extract at 80°C for 1 hour, extract three times, combine three extracts, concentrate to 60°C to a density of 1.02g / mL , dry it, and the yield is 19.6%.
[0039]Wash 100kg of dried poria cocos, crush through a 24-mesh sieve, add its mass to 8 times the volume concentration of 70% ethanol solution, soak for 5 hours, reflux for 3 hours, extract twice, combine the two extracts, concentrate to 55 ° C to The density is 1.07g / mL, dried under reduced pressure, and the yield is 0.40%.
[0040] Wash 16kg of dried jujube, slice it (5-7mm in thickness), mix it with purified water at a mass ratio of 1:30, stir and extract at 90°C for 100 minutes, extract twice, combine the two extracts, and depressurize Concentrate to 55°C until the solid content is 0.16g / mL, the volume of the concentrated solution is 31.2L, the calculated solid content in the concentrated solution is 5.0kg, add the extracts of ros...
Embodiment 3
[0041] Example 3: Evaluation of the effect of compositions on zebrafish locomotion
[0042] The anti-fatigue drug efficacy evaluation model of zebrafish is from the literature: Fan Nengquan, Peng Lan, Yang Wu, Zhang Pu, Jiang Jingzi. A preliminary study on the effect of rhodiola rosea on zebrafish swimming and hypoxia tolerance, "Journal of Pharmaceutical Analysis", 2015 , 8: 1342-1345. The entire contents of which are incorporated herein by reference.
[0043] The experimental animals were wild-type AB strains, and each experimental group consisted of 30 zebrafish, which were incubated in an incubator at 28°C. The normal control group is normal zebrafish treated with fish culture water; the zebrafish is induced with sodium sulfite as the zebrafish hypoxic fatigue model; the composition (batch number Z-1) with a concentration of 5, 17 and 50 μg / mL is taken for evaluation, The zebrafish in the model group were treated with water-soluble samples, and the Zhonghua Dieda Pill wa...
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