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Preparation method for support layer material with lasting water retention for hydrogel patch

A hydrogel patch and water-retaining technology, which is applied in the direction of non-active ingredient medical preparations, pharmaceutical formulas, sheet-like delivery, etc., can solve the problem of affecting the adhesion performance of hydrogel patch products through skin absorption of active ingredients and water loss Fast speed and other issues, to achieve the effect of increasing transdermal efficiency, increasing hydration, and good adhesion

Inactive Publication Date: 2016-11-09
雷春生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem mainly solved by the present invention is to provide a long-lasting water-retaining solution for the fast water loss in the support layer of the hydrogel patch, which affects the adhesion performance of the hydrogel patch product and the transdermal absorption of active ingredients in the hydrogel patch. The preparation method of the support layer material of type hydrogel pasting, in this method, pomelo peel is washed, peeled, decomplexed, and frozen to make pieces, and then mint leaves and eucalyptus leaves are cooled and ground, and deionized water is added to make a mixed slurry. Stir and mix the grapefruit peel pieces and the mixed slurry, suction filter to make modified grapefruit peel pieces, then pulverize and sieve to make powder, add ethanol solution, pectin, sodium alginate, glycerin, stir and mix, and then spin evaporate Concentrate to make a concentrated solution, cast the concentrated solution into a film to obtain a matrix material, then melt polyethylene and evenly coat the surface of the matrix material, and after cooling to room temperature, a durable water-retaining hydrogel paste support layer material is obtained The present invention is easy to operate, and the prepared hydrogel patch support layer can effectively reduce water loss, improve the adhesion performance of the hydrogel patch, improve the transdermal absorption efficiency of active ingredients in the hydrogel patch, and have wide application prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] First, weigh 300g of fresh pomelo peel, wash it repeatedly with deionized water for 3 times manually, peel off the yellow skin on the surface of grapefruit peel with a knife, then remove the white silk, and then cut the remaining white part into pieces with a length of 8mm and a width of 4mm. Put the resulting fragments into boiling water, soak for 6min, filter, collect the soaked grapefruit peel fragments, let stand, cool to room temperature naturally, and set aside; then weigh 10g mint leaves and 8g eucalyptus leaves in turn, and cool them with liquid nitrogen Treat for 30 seconds, quickly put it into a mortar and grind for 8 minutes, mix 8mL of deionized water during the grinding process, and get a mixed slurry; in a closed container filled with 1L of deionized water, add the step by step to prepare spare cooled pomelo peel pieces Mix the slurry with the above-mentioned obtained mixture, stir and mix with a sterilized glass rod for 6 minutes, seal the container, store...

example 2

[0023]First weigh 400g of fresh pomelo peel, wash it 4 times with deionized water manually, peel off the yellow epidermis on the surface of grapefruit peel with a knife, then remove the white silk, and then cut the remaining white part into pieces with a length of 9mm and a width of 5mm. Put the resulting fragments into boiling water, soak for 7min, filter, collect the soaked grapefruit peel fragments, let stand, cool to room temperature naturally, and set aside; then weigh 11g mint leaves and 9g eucalyptus leaves in turn, and cool them with liquid nitrogen After processing for 40 seconds, quickly put it into a mortar and grind for 9 minutes, and mix 9 mL of deionized water during the grinding process to obtain a mixed slurry; in a closed container filled with 1.5 L of deionized water, add step by step to prepare spare cooled pomelo peel After stirring and mixing the block and the above-mentioned mixed slurry with a sterilized glass rod for 7 minutes, seal the container, store ...

example 3

[0026] First, weigh 500g of fresh pomelo peel, wash it 5 times with deionized water manually, peel off the yellow epidermis on the surface of grapefruit peel with a knife, then remove the white silk, and then cut the remaining white part into 10mm long, 6mm wide pieces Put the resulting fragments into boiling water, soak for 8min, filter, collect the soaked grapefruit peel fragments, let stand, cool to room temperature naturally, and set aside; then weigh 12g mint leaves and 10g eucalyptus leaves in turn, and cool them with liquid nitrogen After processing for 50 seconds, quickly put it into a mortar and grind for 10 minutes. During the grinding process, mix 10 mL of deionized water to obtain a mixed slurry; in a closed container filled with 2L of deionized water, add the steps in turn to prepare spare cooled pomelo peel pieces Mix the slurry with the above-mentioned obtained mixture, stir and mix with a sterilized glass rod for 8 minutes, seal the container, store in a dark pl...

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Abstract

The invention discloses a preparation method for a support layer material with lasting water retention for a hydrogel patch, and belongs to the technical field of preparation of hydrogel patches. The method comprises the following steps: washing, removing, unthreading and freezing pomelo peel to prepare pieces, and cooling, grinding and adding mint leaves and eucalyptus leaves into de-ionized water to prepare mixed slurry; performing stirring and suction filtration on the pomelo peel pieces and the mixed slurry to prepare modified pomelo peel pieces, crushing the modified pomelo peel pieces into powder, adding an ethanol solution, pectin, sodium alginate and glycerin, and performing stirring mixing and rotary evaporation concentration to obtain a concentrated solution; preparing a coiled thin film from the concentrated solution to obtain a substrate material, melting polyethylene, uniformly coating the surface of the substrate material with the molten polyethylene, and performing cooling to room temperature to obtain the support layer material with lasting water retention. Examples show that the preparation method is convenient to operate; by a prepared support layer of the hydrogel patch, water loss can be effectively reduced, the adhesion property of the hydrogel patch can be improved, and the transdermal absorption efficiency of active ingredients in the hydrogel patch can be improved; the preparation method has broad application prospect.

Description

technical field [0001] The invention discloses a preparation method of a durable water-retaining hydrogel plaster support layer material, and belongs to the technical field of hydrogel plaster preparation. Background technique [0002] Hydrogel is a kind of polymer with a three-dimensional network structure, which can absorb a large amount of water and swell in water, and can continue to maintain its original structure without being dissolved after swelling. Its main ingredients are hydrophilic resin, purified water, moisturizing agent, and cross-linking agent, which is a cross-linked polymer that swells with water. Mainly used for external gel patches. Such as hydrogel antipyretic patch for children, hydrogel eye patch, hydrogel eye bag patch, hydrogel mask patch, this dosage form originated in Japan, mainly mixing chemical drugs with a suitable hydrophilic hydrogel matrix Finally, the hydrogel plaster made on the backing material is coated. It consists of a support laye...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/36A61K47/46
CPCA61K9/7023A61K47/32A61K47/36A61K47/46
Inventor 雷春生许博伟薛蕾
Owner 雷春生
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